Design, synthesis, kinetic mechanism and molecular docking studies of novel 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers.

[1]  J. Whitaker.  Principles of Enzymology for the Food Sciences , 2018 .

[2]  A. Saeed,et al.  Application of Lawesson’s reagent in the synthesis of sulfur-containing medicinally significant natural alkaloids , 2017 .

[3]  A. Saeed,et al.  New 1-octanoyl-3-aryl thiourea derivatives: Solvent-free synthesis, characterization and multi-target biological activities , 2016 .

[4]  A. Saeed,et al.  Synthetic Approaches to the Multifunctional Drug Ebselen and Analogs: Past and Present , 2016 .

[5]  Mubashir Hassan,et al.  Exploration of Novel Human Tyrosinase Inhibitors by Molecular Modeling, Docking and Simulation Studies , 2016, Interdisciplinary Sciences: Computational Life Sciences.

[6]  Kam Y. J. Zhang,et al.  Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. , 2015, Bioorganic chemistry.

[7]  M. Rafiq,et al.  Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase. , 2015, Bioorganic & medicinal chemistry.

[8]  M. Rafiq,et al.  Kinetic and in silico studies of novel hydroxy-based thymol analogues as inhibitors of mushroom tyrosinase. , 2015, European journal of medicinal chemistry.

[9]  U. Flörke,et al.  New aminobenzenesulfonamide-thiourea conjugates: synthesis and carbonic anhydrase inhibition and docking studies. , 2014, European journal of medicinal chemistry.

[10]  A. Saeed,et al.  Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases. , 2014, European journal of medicinal chemistry.

[11]  A. Saeed,et al.  Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: synthetic approaches and multifarious applications. , 2014, European journal of medicinal chemistry.

[12]  U. Flörke,et al.  A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3-(substituted) thioureas , 2014 .

[13]  J. Bajorath,et al.  Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors. , 2013, European journal of medicinal chemistry.

[14]  A. Saeed,et al.  Synthesis, molecular docking studies, and in vitro screening of sulfanilamide-thiourea hybrids as antimicrobial and urease inhibitors , 2013, Medicinal Chemistry Research.

[15]  A. Saeed,et al.  Journey of the ALK-inhibitor CH5424802 to phase II clinical trial , 2013, Archives of pharmacal research.

[16]  C. Rovira,et al.  Three-dimensional porous metal-radical frameworks based on triphenylmethyl radicals. , 2012, Chemistry.

[17]  A. Saeed,et al.  Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors. , 2011, European journal of medicinal chemistry.

[18]  A. Todaro,et al.  Study and characterization of polyphenol oxidase from eggplant (Solanum melongena L.). , 2011, Journal of agricultural and food chemistry.

[19]  R. Cao,et al.  Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. , 2010, European journal of medicinal chemistry.

[20]  R. Khera,et al.  Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas , 2010, Turkish Journal of Chemistry.

[21]  Vincent B. Chen,et al.  Correspondence e-mail: , 2000 .

[22]  A. Hameed,et al.  Synthesis, characterization and antimicrobial activity of some new 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas , 2009 .

[23]  Te-Sheng Chang,et al.  An Updated Review of Tyrosinase Inhibitors , 2009, International journal of molecular sciences.

[24]  Bo Liu,et al.  Antityrosinase and antimicrobial activities of trans-cinnamaldehyde thiosemicarbazone. , 2009, Journal of agricultural and food chemistry.

[25]  A. Saeed.  Microwave‐Assisted Synthesis of cAMP Phosphodiesterase Inhibitor 8‐Hydroxy‐6,7‐dimethoxy‐3‐hydroxymethylisocoumarin , 2007 .

[26]  Mahmud Tareq Hassan Khan.  Molecular design of tyrosinase inhibitors: A critical review of promising novel inhibitors from synthetic origins , 2007 .

[27]  Mahmud Tareq Hassan Khan,et al.  Oxazolones: new tyrosinase inhibitors; synthesis and their structure-activity relationships. , 2006, Bioorganic & medicinal chemistry.

[28]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[29]  M. Marshall,et al.  PHYSICOCHEMICAL PROPERTIES AND FUNCTION OF PLANT POLYPHENOL OXIDASE: A REVIEW' , 2003 .

[30]  David S. Wishart,et al.  VADAR: a web server for quantitative evaluation of protein structure quality , 2003, Nucleic Acids Res..

[31]  V. Sharma,et al.  Mushroom tyrosinase: recent prospects. , 2003, Journal of agricultural and food chemistry.

[32]  Ian W. Davis,et al.  Structure validation by Cα geometry: ϕ,ψ and Cβ deviation , 2003, Proteins.

[33]  A. Shabana,et al.  Vibrational and electronic studies on some metal thiourea complexes , 2003 .

[34]  김석중,et al.  Tyrosinase 활성을 저해하는 식물체의 탐색 , 1995 .

[35]  M. Pittelkow,et al.  Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. , 1994, Science.

[36]  A. Saeed,et al.  C-H Arylation using acyl thiourea ligands:Applications in the synthesis of 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles , 2016 .

[37]  Arthur J Olson,et al.  Small-molecule library screening by docking with PyRx. , 2015, Methods in molecular biology.

[38]  Yujing Zhu,et al.  Antityrosinase and antimicrobial activities of 2-phenylethanol, 2-phenylacetaldehyde and 2-phenylacetic acid , 2011 .