The Mirror Mechanism as Neurophysiological Basis for Action and Intention Understanding

Mirror neurons are neurons discovered in the premotor and parietal cortex that become active during observation and execution of motor acts indicating their crucial role in action understanding. There is, however, still controversy about their role in social cognition and its contribution to understanding others’ actions and intentions. Recent studies in monkeys and humans have shed light on the properties of the parieto-frontal mirror system and its functional relevance for cognition. We conclude that, although there are several mechanisms through which one can understand other individuals’ behavior, the parieto-frontal mirror mechanism is the only one that allows understanding others’ actions from the inside and gives the observing individual a first-person person grasp of other individuals’ motor goals and intentions.

[1]  S. Cochin,et al.  Perception of motion and qEEG activity in human adults. , 1998, Electroencephalography and clinical neurophysiology.

[2]  G. Rizzolatti,et al.  The Cortical Motor System , 2001, Neuron.

[3]  G. Rizzolatti,et al.  Action recognition in the premotor cortex. , 1996, Brain : a journal of neurology.

[4]  C. Keysers,et al.  Integrating simulation and theory of mind: from self to social cognition , 2007, Trends in Cognitive Sciences.

[5]  H. Kornhuber,et al.  Distribution of readiness potential, pre-motion positivity, and motor potential of the human cerebral cortex preceding voluntary finger movements , 2004, Experimental Brain Research.

[6]  G. Rizzolatti,et al.  Functional organization of inferior area 6 in the macaque monkey , 2004, Experimental Brain Research.

[7]  G. Rizzolatti,et al.  Understanding motor events: a neurophysiological study , 2004, Experimental Brain Research.

[8]  J. F. Prather,et al.  Precise auditory–vocal mirroring in neurons for learned vocal communication , 2008, Nature.

[9]  A. Meltzoff,et al.  A PET Exploration of the Neural Mechanisms Involved in Reciprocal Imitation , 2002, NeuroImage.

[10]  J. Mazziotta,et al.  Grasping the Intentions of Others with One's Own Mirror Neuron System , 2005, PLoS biology.

[11]  J. Danckert Common Mechanisms in Perception and Action: Attention and Performance XIX Wolfgang Prinz, Bernhard Hommel (Eds.), Oxford University Press, 2002, Price: £ 65.00, ISBN: 0-19-851069 , 2003, Neuropsychologia.

[12]  G. Luppino,et al.  Cortical connections of the anterior (F5a) subdivision of the macaque ventral premotor area F5 , 2011, Brain Structure and Function.

[13]  C. Keysers,et al.  The Observation and Execution of Actions Share Motor and Somatosensory Voxels in all Tested Subjects: Single-Subject Analyses of Unsmoothed fMRI Data , 2008, Cerebral cortex.

[14]  J. Hyvärinen Posterior parietal lobe of the primate brain. , 1982, Physiological reviews.

[15]  Leonardo Fogassi,et al.  The inferior parietal lobule: where action becomes perception. , 2006, Novartis Foundation symposium.

[16]  Á. Pascual-Leone,et al.  Phase-specific modulation of cortical motor output during movement observation , 2001, Neuroreport.

[17]  Jonathan D. Nelson,et al.  Human cortical representations for reaching: Mirror neurons for execution, observation, and imagery , 2007, NeuroImage.

[18]  Joëlle Martineau,et al.  Impaired cortical activation in autistic children: is the mirror neuron system involved? , 2008, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[19]  Joseph P. McCleery,et al.  EEG evidence for mirror neuron dysfunction in autism spectrum disorders. , 2005, Brain research. Cognitive brain research.

[20]  G. Rizzolatti,et al.  Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study , 2001, The European journal of neuroscience.

[21]  Carlo Adolfo Porro,et al.  Neural substrates for observing and imagining non-object-directed actions , 2008, Social neuroscience.

[22]  Maria Alessandra Umiltà,et al.  Responses of mirror neurons in area F5 to hand and tool grasping observation , 2010, Experimental Brain Research.

[23]  Justin N. Wood,et al.  Action comprehension in non-human primates: motor simulation or inferential reasoning? , 2008, Trends in Cognitive Sciences.

[24]  HighWire Press Philosophical Transactions of the Royal Society of London , 1781, The London Medical Journal.

[25]  G. Rizzolatti,et al.  Parietal Lobe: From Action Organization to Intention Understanding , 2005, Science.

[26]  G. Rizzolatti,et al.  The mirror neuron system. , 2009, Archives of neurology.

[27]  D I Perrett,et al.  Organization and functions of cells responsive to faces in the temporal cortex. , 1992, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[28]  G. Rizzolatti,et al.  Functional Organization of Inferior Parietal Lobule Convexity in the Macaque Monkey: Electrophysiological Characterization of Motor, Sensory and Mirror Responses and Their Correlation with Cytoarchitectonic Areas , 2022 .

[29]  M. Goldberg,et al.  Ventral intraparietal area of the macaque: anatomic location and visual response properties. , 1993, Journal of neurophysiology.

[30]  D. Pandya,et al.  Intrinsic connections and architectonics of posterior parietal cortex in the rhesus monkey , 1982, The Journal of comparative neurology.

[31]  M. Goldberg,et al.  Ventral intraparietal area of the macaque: congruent visual and somatic response properties. , 1998, Journal of neurophysiology.

[32]  C. Heyes,et al.  Weak imitative performance is not due to a functional ‘mirroring’ deficit in adults with Autism Spectrum Disorders , 2008, Neuropsychologia.

[33]  Á. Pascual-Leone,et al.  Impaired motor facilitation during action observation in individuals with autism spectrum disorder , 2005, Current Biology.

[34]  A. Murata,et al.  Cortical connections of the macaque anterior intraparietal (AIP) area. , 2008, Cerebral cortex.

[35]  T. Paus,et al.  Modulation of cortical excitability during action observation: a transcranial magnetic stimulation study , 2000, Neuroreport.

[36]  G. Rizzolatti,et al.  I Know What You Are Doing A Neurophysiological Study , 2001, Neuron.

[37]  Roel M. Willems,et al.  Complementary Systems for Understanding Action Intentions , 2008, Current Biology.

[38]  G. Rizzolatti,et al.  Premotor cortex and the recognition of motor actions. , 1996, Brain research. Cognitive brain research.

[39]  G. Rizzolatti,et al.  Activation of human primary motor cortex during action observation: a neuromagnetic study. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Emily S. Cross,et al.  Building a motor simulation de novo: Observation of dance by dancers , 2006, NeuroImage.

[41]  Hans-Jochen Heinze,et al.  Shared networks for auditory and motor processing in professional pianists: Evidence from fMRI conjunction , 2006, NeuroImage.

[42]  J. Wallman,et al.  Behavioural neuroscience: Neurons of imitation , 2008, Nature.

[43]  G Rizzolatti,et al.  When pliers become fingers in the monkey motor system , 2008, Proceedings of the National Academy of Sciences.

[44]  G. Rizzolatti,et al.  Resonance behaviors and mirror neurons. , 1999, Archives italiennes de biologie.

[45]  G. Rizzolatti,et al.  Patterns of cytochrome oxidase activity in the frontal agranular cortex of the macaque monkey , 1985, Behavioural Brain Research.

[46]  Francesca Ugolotti Serventi,et al.  Ventral premotor and inferior parietal cortices make distinct contribution to action organization and intention understanding. , 2010, Cerebral cortex.

[47]  Luciano Fadiga,et al.  Do We Really Need Vision? How Blind People “See” the Actions of Others , 2009, The Journal of Neuroscience.

[48]  C. Frith,et al.  Action Observation: Inferring Intentions without Mirror Neurons , 2008, Current Biology.

[49]  G. Orban,et al.  The Representation of Tool Use in Humans and Monkeys: Common and Uniquely Human Features , 2009, The Journal of Neuroscience.

[50]  M. Arbib,et al.  Grasping objects: the cortical mechanisms of visuomotor transformation , 1995, Trends in Neurosciences.

[51]  Georg B. Keller,et al.  Neural processing of auditory feedback during vocal practice in a songbird , 2009, Nature.

[52]  G. Rizzolatti,et al.  Neural Circuits Involved in the Recognition of Actions Performed by Nonconspecifics: An fMRI Study , 2004, Journal of Cognitive Neuroscience.

[53]  G. Rizzolatti,et al.  The organization of the cortical motor system: new concepts. , 1998, Electroencephalography and clinical neurophysiology.

[54]  Robert O Deaner,et al.  Mirroring of attention by neurons in macaque parietal cortex , 2009, Proceedings of the National Academy of Sciences.

[55]  Jennifer H. Pfeifer,et al.  Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders , 2006, Nature Neuroscience.

[56]  D. Hoffman,et al.  Direction of action is represented in the ventral premotor cortex , 2001, Nature Neuroscience.

[57]  U. Frith Autism: Explaining the enigma, 2nd ed. , 2003 .

[58]  Alexander Kraskov,et al.  Corticospinal Neurons in Macaque Ventral Premotor Cortex with Mirror Properties: A Potential Mechanism for Action Suppression? , 2009, Neuron.

[59]  A. Hamilton,et al.  Imitation and action understanding in autistic spectrum disorders: How valid is the hypothesis of a deficit in the mirror neuron system? , 2007, Neuropsychologia.

[60]  V. Gallese Before and below ‘theory of mind’: embodied simulation and the neural correlates of social cognition , 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

[61]  E. Saltzman,et al.  Action Representation of Sound: Audiomotor Recognition Network While Listening to Newly Acquired Actions , 2007, The Journal of Neuroscience.

[62]  G. Rizzolatti,et al.  Intention Understanding in Autism , 2009, PloS one.

[63]  G. Rizzolatti,et al.  Mirror neurons and motor intentionality. , 2007, Functional neurology.

[64]  G. Luppino,et al.  Cortical connections of the inferior parietal cortical convexity of the macaque monkey. , 2006, Cerebral cortex.

[65]  G. Rizzolatti,et al.  Motor facilitation during action observation: a magnetic stimulation study. , 1995, Journal of neurophysiology.

[66]  R. Andersen,et al.  Saccade-related activity in the lateral intraparietal area. II. Spatial properties. , 1991, Journal of neurophysiology.

[67]  G. Rizzolatti,et al.  Localization of grasp representations in humans by PET: 1. Observation versus execution , 1996, Experimental Brain Research.

[68]  H. Sakata,et al.  Neural mechanisms of visual guidance of hand action in the parietal cortex of the monkey. , 1995, Cerebral cortex.

[69]  G. Rizzolatti,et al.  Impairment of actions chains in autism and its possible role in intention understanding , 2007, Proceedings of the National Academy of Sciences.

[70]  G. Rizzolatti,et al.  Mirror Neurons Differentially Encode the Peripersonal and Extrapersonal Space of Monkeys , 2009, Science.

[71]  D. Stainier,et al.  A Cellular Framework for Gut-Looping Morphogenesis in Zebrafish , 2003, Science.

[72]  Marcel Brass,et al.  How do we infer others' goals from non-stereotypic actions? The outcome of context-sensitive inferential processing in right inferior parietal and posterior temporal cortex , 2008, NeuroImage.

[73]  Hiroaki Ishida,et al.  Shared Mapping of Own and Others' Bodies in Visuotactile Bimodal Area of Monkey Parietal Cortex , 2010, Journal of Cognitive Neuroscience.

[74]  Elena Borra,et al.  Architectonic organization of the inferior parietal convexity of the macaque monkey , 2006, The Journal of comparative neurology.

[75]  M. Brass,et al.  Investigating Action Understanding: Inferential Processes versus Action Simulation , 2007, Current Biology.

[76]  C. Frith,et al.  Relationship between Activity in Human Primary Motor Cortex during Action Observation and the Mirror Neuron System , 2009, PloS one.

[77]  G. Rizzolatti,et al.  Hearing Sounds, Understanding Actions: Action Representation in Mirror Neurons , 2002, Science.

[78]  Christian Keysers,et al.  Aplasics Born without Hands Mirror the Goal of Hand Actions with Their Feet , 2007, Current Biology.

[79]  G. Rizzolatti,et al.  Coding of peripersonal space in inferior premotor cortex (area F4). , 1996, Journal of neurophysiology.

[80]  S. Blakemore,et al.  Motor activation prior to observation of a predicted movement , 2004, Nature Neuroscience.

[81]  R. Passingham,et al.  Action observation and acquired motor skills: an FMRI study with expert dancers. , 2005, Cerebral cortex.

[82]  Christian Keysers,et al.  The anthropomorphic brain: The mirror neuron system responds to human and robotic actions , 2007, NeuroImage.

[83]  G. Rizzolatti,et al.  Architecture of superior and mesial area 6 and the adjacent cingulate cortex in the macaque monkey , 1991, The Journal of comparative neurology.