论文信息 - Interstimulus Interval Affects Population Response in Visual Cortex in vivo

Interstimulus Interval Affects Population Response in Visual Cortex in vivo

Understanding the underlying properties of neuronal populations over single neurons is a longstanding goal for both basic and applied neurosciences, with a specifically suitable application in the field of neuroprosthesis development, aimed to restore the loss of function of a visual cortex as a result of an injury or disease. We study how the interstimulus interval (ISI) period of a repeated visual stimulus influences the overall activity of rat visual cortex neuronal populations. Our results suggest that certain (3, 5 s) interstimulus intervals do have an increased stimulus response compared to longer or shorter ISIs for a 500 ms grating drifting stimulus. Based on the preliminary results shown in this article, we claim the need of a better understanding of the biological dynamics of the visual cortex neuronal populations in order to properly design suitable brain-machine interfaces for visual neurorehabilitation intracortical neuroprosthetics.

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