A metric for the cognitive map: found at last?

A network of brain areas collectively represent location, but the underlying nature of this "cognitive map" has remained elusive. A recent study reports that the activity patterns of some entorhinal cortical neurons form a remarkably regular array of evenly spaced peaks across the surface of the environment. These "grid cells" might be the basis of a metric used for calculating position, and their discovery could greatly advance our understanding of how navigational computations are performed.

[1]  T. Hafting,et al.  Microstructure of a spatial map in the entorhinal cortex , 2005, Nature.

[2]  E. Tolman Cognitive maps in rats and men. , 1948, Psychological review.

[3]  E. Rolls Spatial view cells and the representation of place in the primate hippocampus , 1999, Hippocampus.

[4]  W E Skaggs,et al.  Deciphering the hippocampal polyglot: the hippocampus as a path integration system. , 1996, The Journal of experimental biology.

[5]  Hisao Nishijo,et al.  Representation of place by monkey hippocampal neurons in real and virtual translocation , 2003, Hippocampus.

[6]  J. Taube Head direction cells and the neurophysiological basis for a sense of direction , 1998, Progress in Neurobiology.

[7]  Ariane S Etienne,et al.  Path integration in mammals , 2004, Hippocampus.

[8]  David Wood,et al.  Luddites must not block progress in genetics , 1999, Nature.

[9]  H. Eichenbaum,et al.  The global record of memory in hippocampal neuronal activity , 1999, Nature.

[10]  J. O’Keefe,et al.  Geometric determinants of the place fields of hippocampal neurons , 1996, Nature.

[11]  R. Muller,et al.  The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  K. Zhang,et al.  Representation of spatial orientation by the intrinsic dynamics of the head-direction cell ensemble: a theory , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[13]  R. Passingham The hippocampus as a cognitive map J. O'Keefe & L. Nadel, Oxford University Press, Oxford (1978). 570 pp., £25.00 , 1979, Neuroscience.

[14]  Arne D. Ekstrom,et al.  Cellular networks underlying human spatial navigation , 2003, Nature.

[15]  J. Knierim,et al.  Major Dissociation Between Medial and Lateral Entorhinal Input to Dorsal Hippocampus , 2005, Science.

[16]  J. O’Keefe,et al.  Dual phase and rate coding in hippocampal place cells: Theoretical significance and relationship to entorhinal grid cells , 2005, Hippocampus.