Distinct requirement for an intact dimer interface in wild‐type, V600E and kinase‐dead B‐Raf signalling
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A. von Deimling | D. Capper | S. Braun | T. Brummer | D. Saunders | Gina J. Fiala | W. Schamel | Katharina Heilmann | A. Eisenhardt | Michael Röring | Ricarda Herr | Sebastian Halbach
[1] K. Flaherty,et al. RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. , 2012, The New England journal of medicine.
[2] Marc Therrien,et al. Cancer: A drug-resistant duo , 2011, Nature.
[3] A. Eggermont,et al. Skin Tumors Induced by Sorafenib; Paradoxic RAS–RAF Pathway Activation and Oncogenic Mutations of HRAS, TP53, and TGFBR1 , 2011, Clinical Cancer Research.
[4] S. Pfister,et al. Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma , 2011, International journal of cancer.
[5] Tom Misteli,et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) , 2011, Nature.
[6] C. Pritchard,et al. Mechanisms of aneuploidy induction by RAS and RAF oncogenes. , 2011, American journal of cancer research.
[7] S. Lacomme,et al. BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis , 2011, Pathology.
[8] C. Berens,et al. A novel MCF-10A line allowing conditional oncogene expression in 3D culture , 2011, Cell Communication and Signaling.
[9] K. Flaherty,et al. BRAF targeted therapy changes the treatment paradigm in melanoma , 2011, Nature Reviews Clinical Oncology.
[10] A. Hauschild,et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. , 2011, The New England journal of medicine.
[11] H. Zentgraf,et al. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody , 2011, Acta Neuropathologica.
[12] Nils Blüthgen,et al. Strong negative feedback from Erk to Raf confers robustness to MAPK signalling , 2011, Molecular systems biology.
[13] Alma L. Burlingame,et al. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK , 2011, Nature.
[14] D. Morrison,et al. RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling , 2011, Current Biology.
[15] G. Mann,et al. Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[16] Charles Swanton,et al. Genetic prognostic and predictive markers in colorectal cancer , 2011, Nature Reviews Cancer.
[17] David B Solit,et al. Resistance to MEK Inhibitors: Should We Co-Target Upstream? , 2011, Science Signaling.
[18] P. Edwards,et al. Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells , 2011, Science Signaling.
[19] U. Rapp,et al. Single Substitution within the RKTR Motif Impairs Kinase Activity but Promotes Dimerization of RAF Kinase* , 2011, The Journal of Biological Chemistry.
[20] W. Kolch,et al. Raf family kinases: old dogs have learned new tricks. , 2011, Genes & cancer.
[21] Julian Downward,et al. Targeting RAF: trials and tribulations , 2011, Nature Medicine.
[22] N. Rosen,et al. Resistance to BRAF inhibition in melanomas. , 2011, The New England journal of medicine.
[23] R. Oostendorp,et al. Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1 , 2011, Leukemia.
[24] Kirsten Schmieder,et al. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma , 2011, Acta Neuropathologica.
[25] A. Aplin,et al. Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells , 2011, Oncogene.
[26] N. Rosen,et al. Mutant BRAF melanomas--dependence and resistance. , 2011, Cancer cell.
[27] S. Nelson,et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation , 2010, Nature.
[28] D. Solit,et al. Drug discovery: How melanomas bypass new therapy , 2010, Nature.
[29] M. Baccarini,et al. Partner exchange: protein-protein interactions in the Raf pathway. , 2010, Trends in biochemical sciences.
[30] A. Iafrate,et al. BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation , 2010, Science Signaling.
[31] Kam Y. J. Zhang,et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma , 2010, Nature.
[32] M. Belvin,et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth , 2010, Nature.
[33] Chao Zhang,et al. RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF , 2010, Nature.
[34] Karen Cichowski,et al. Drug discovery: Inhibitors that activate , 2010, Nature.
[35] C. Der,et al. The raf inhibitor paradox: unexpected consequences of targeted drugs. , 2010, Cancer cell.
[36] J. Reis-Filho,et al. Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF , 2010, Cell.
[37] Ursula Klingmüller,et al. Theoretical and experimental analysis links isoform- specific ERK signalling to cell fate decisions , 2009, Molecular systems biology.
[38] D. Morrison,et al. Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling , 2009, Molecular and Cellular Biology.
[39] D. Tuveson,et al. C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). , 2009, Molecular cell.
[40] M. Watson,et al. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma , 2009, Neurology.
[41] E. Oikonomou,et al. BRAFV600E Efficient Transformation and Induction of Microsatellite Instability Versus KRASG12V Induction of Senescence Markers in Human Colon Cancer Cells , 2009 .
[42] S. Hirohashi,et al. Resequencing Analysis of the Human Tyrosine Kinase Gene Family in Pancreatic Cancer , 2009, Pancreas.
[43] Marc Therrien,et al. A dimerization-dependent mechanism drives RAF catalytic activation , 2009, Nature.
[44] S. Feller,et al. Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation. , 2009, Cancer research.
[45] D. Pearson,et al. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma , 2009, Oncogene.
[46] K. Resing,et al. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. , 2009, Molecular cell.
[47] M. Digilio,et al. Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: Molecular diversity and associated phenotypic spectrum , 2009, Human mutation.
[48] C. Noelke,et al. MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib , 2009, Molecular Cancer Therapeutics.
[49] U. Rapp,et al. Regulation of RAF Activity by 14-3-3 Proteins , 2009, Journal of Biological Chemistry.
[50] A. Jaffe,et al. Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis , 2008, The Journal of cell biology.
[51] J. Hussain,et al. CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation. , 2008, Molecular cell.
[52] R. Seruca,et al. B-Raf(V600E) cooperates with alternative spliced Rac1b to sustain colorectal cancer cell survival. , 2008, Gastroenterology.
[53] Kam Y. J. Zhang,et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity , 2008, Proceedings of the National Academy of Sciences.
[54] D. Peeper,et al. BRAFE600 in benign and malignant human tumours , 2008, Oncogene.
[55] M. Therrien,et al. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation , 2007, Oncogene.
[56] M. Reth,et al. Functional analysis of the regulatory requirements of B-Raf and the B-RafV600E oncoprotein , 2006, Oncogene.
[57] M. Matsuda,et al. The amino‐terminal B‐Raf‐specific region mediates calcium‐dependent homo‐ and hetero‐dimerization of Raf , 2006, The EMBO journal.
[58] Pablo Rodriguez-Viciana,et al. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. , 2006, Molecular cell.
[59] Pablo Rodriguez-Viciana,et al. Germline Mutations in Genes Within the MAPK Pathway Cause Cardio-facio-cutaneous Syndrome , 2006, Science.
[60] W. Kolch,et al. Regulation and Role of Raf-1/B-Raf Heterodimerization , 2006, Molecular and Cellular Biology.
[61] R. Hennekam,et al. Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome , 2006, Nature Genetics.
[62] Alcino J. Silva,et al. Forebrain‐specific knockout of B‐raf kinase leads to deficits in hippocampal long‐term potentiation, learning, and memory , 2006, Journal of neuroscience research.
[63] D. Barford,et al. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. , 2005, Molecular cell.
[64] M. Garnett,et al. Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF. , 2005, Cancer research.
[65] Dirk Strumberg,et al. Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[66] Mathew J Garnett,et al. Guilty as charged: B-RAF is a human oncogene. , 2004, Cancer cell.
[67] D. Auclair,et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis , 2004, Cancer Research.
[68] D. Barford,et al. Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.
[69] R. Aebersold,et al. Two-dimensional Blue Native/SDS Gel Electrophoresis of Multi-Protein Complexes from Whole Cellular Lysates , 2004, Molecular & Cellular Proteomics.
[70] M. Reth,et al. Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf , 2003, Oncogene.
[71] D. Tuveson,et al. Suppression of BRAF(V599E) in human melanoma abrogates transformation. , 2003, Cancer research.
[72] M. Reth,et al. Inducible gene deletion reveals different roles for B‐Raf and Raf‐1 in B‐cell antigen receptor signalling , 2002, The EMBO journal.
[73] R. Marais,et al. 14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity , 2002, Molecular and Cellular Biology.
[74] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[75] P. Khavari,et al. Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation , 2002, Oncogene.
[76] W. Kolch,et al. Regulation of Raf‐1 activation and signalling by dephosphorylation , 2002, The EMBO journal.
[77] K. Guan,et al. Positive and negative regulation of Raf kinase activity and function by phosphorylation , 2001, The EMBO journal.
[78] J. Hancock,et al. Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions , 2001, Oncogene.
[79] U. Rapp,et al. Active Ras induces heterodimerization of cRaf and BRaf. , 2001, Cancer research.
[80] K. Guan,et al. Activation of B‐Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601 , 2000, The EMBO journal.
[81] T. Barber,et al. Negative regulation of the serine/threonine kinase B-Raf by Akt. , 2000, The Journal of biological chemistry.
[82] W. Kolch,et al. Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation* , 2000, The Journal of Biological Chemistry.
[83] Anthony J. Muslin,et al. Disruption of the 14-3-3 Binding Site within the B-Raf Kinase Domain Uncouples Catalytic Activity from PC12 Cell Differentiation* , 2000, The Journal of Biological Chemistry.
[84] Giulio Superti‐Furga,et al. Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation , 1999, The EMBO journal.
[85] A. Eychène,et al. Modulation of Kinase Activity and Oncogenic Properties by Alternative Splicing Reveals a Novel Regulatory Mechanism for B-Raf* , 1998, The Journal of Biological Chemistry.
[86] C. Marshall,et al. Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases* , 1997, The Journal of Biological Chemistry.
[87] Sally J. Leevers,et al. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane , 1994, Nature.
[88] S. Shirasawa,et al. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. , 1993, Science.
[89] J. Cunningham,et al. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection , 1989, Cell.
[90] G K Lewis,et al. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product , 1985, Molecular and cellular biology.
[91] P. Seeburg,et al. Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations , 1983, Nature.
[92] A. McCullough. RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors , 2013 .
[93] Walter Kolch,et al. Biology using engineering tools: The negative feedback amplifier , 2022 .