Recovery of visual responses in foveal V1 neurons following bilateral foveal lesions in adult monkey

SummaryCells in the foveal representation of V1 cortex of adult primates became visually responsive after normal sensory input was removed. Immediately after foveae were lesioned bilaterally, a region was found where no cells' activity could be modulated by visual stimulation. Recordings made in that deafferented zone at > 2.5 months after lesions revealed that activity of over half of the cells could be modulated by visual stimuli presented to intact peripheral retina. Although response characteristics made cells with recovered driving quite unlike normal cells, the result suggests a level of visual cortical reorganization previously observed only in immature animals.

[1]  G. F. Cooper,et al.  Development of the Brain depends on the Visual Environment , 1970, Nature.

[2]  S. Schein,et al.  Density profile of blue-sensitive cones along the horizontal meridian of macaque retina. , 1985, Investigative ophthalmology & visual science.

[3]  D. Robinson,et al.  A METHOD OF MEASURING EYE MOVEMENT USING A SCLERAL SEARCH COIL IN A MAGNETIC FIELD. , 1963, IEEE transactions on bio-medical engineering.

[4]  D. Hubel,et al.  Receptive fields, binocular interaction and functional architecture in the cat's visual cortex , 1962, The Journal of physiology.

[5]  D. Hubel,et al.  Receptive fields and functional architecture of monkey striate cortex , 1968, The Journal of physiology.

[6]  D. Snodderly,et al.  Eye position during fixation tasks: Comparison of macaque and human , 1985, Vision Research.

[7]  David A. Robinson,et al.  Miniature eye movements of fixation in rhesus monkey , 1975, Vision Research.

[8]  D. Hubel,et al.  Uniformity of monkey striate cortex: A parallel relationship between field size, scatter, and magnification factor , 1974, The Journal of comparative neurology.

[9]  U. Eysel,et al.  Time-dependent decrease in the extent of visual deafferentation in the lateral geniculate nucleus of adult cats with small retinal lesions , 2004, Experimental Brain Research.

[10]  E. Evarts.  A technique for recording activity of subcortical neurons in moving animals. , 1968, Electroencephalography and clinical neurophysiology.

[11]  T. Wiesel,et al.  Columnar specificity of intrinsic horizontal and corticocortical connections in cat visual cortex , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  D. Hubel,et al.  The period of susceptibility to the physiological effects of unilateral eye closure in kittens , 1970, The Journal of physiology.

[13]  W. Cowan.  The development of the brain. , 1979, Scientific American.

[14]  D. Hubel,et al.  The development of ocular dominance columns in normal and visually deprived monkeys , 1980, The Journal of comparative neurology.

[15]  H. Gerrits,et al.  The filling-in process in patients with retinal scotomata. , 1969, Vision research.

[16]  T. Wiesel,et al.  Relationships between horizontal interactions and functional architecture in cat striate cortex as revealed by cross-correlation analysis , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  A. Fuchs,et al.  A method for measuring horizontal and vertical eye movement chronically in the monkey. , 1966, Journal of applied physiology.

[18]  M. Cynader,et al.  Somatosensory cortical map changes following digit amputation in adult monkeys , 1984, The Journal of comparative neurology.

[19]  J. Kaas,et al.  Reorganization of retinotopic cortical maps in adult mammals after lesions of the retina. , 1990, Science.

[20]  J. Lund,et al.  Intrinsic laminar lattice connections in primate visual cortex , 1983, The Journal of comparative neurology.

[21]  D. N. Spinelli,et al.  Modification of the distribution of receptive field orientation in cats by selective visual exposure during development , 1971, Experimental Brain Research.

[22]  R. Vautin,et al.  Magnification factor and receptive field size in foveal striate cortex of the monkey , 2004, Experimental Brain Research.

[23]  M. Stryker,et al.  Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation. , 1978, The Journal of physiology.