Cardiovascular Magnetic Resonance Imaging and MR-Conditional Cardiac Devices

This chapter provides a condensed review of the basic principles of magnetic resonance imaging (MRI) and introduces the reader to some of the concepts and terminology necessary to understand the use of MRI to study the heart. We then proceed to describe a wide range of MRI cardiac applications, both in vivo and ex vivo, which should interest the biomedical engineer. While the capabilities of cardiac MRI are quite extensive, our choice of topics for this chapter is rather judicious, as cardiac MRI has evolved to the point where entire books are published on the subject.

[1]  Phillip Moore,et al.  MRI‐guided congenital cardiac catheterization and intervention: The future? , 2005, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[2]  S. Plein,et al.  Steady‐state free precession magnetic resonance imaging of the heart: Comparison with segmented k‐space gradient‐echo imaging , 2001, Journal of magnetic resonance imaging : JMRI.

[3]  Timothy G Reese,et al.  Imaging myocardial fiber disarray and intramural strain hypokinesis in hypertrophic cardiomyopathy with MRI , 2006, Journal of magnetic resonance imaging : JMRI.

[4]  T. Arts,et al.  Characterization of the normal cardiac myofiber field in goat measured with MR-diffusion tensor imaging. , 2002, American journal of physiology. Heart and circulatory physiology.

[5]  E. Atalar,et al.  Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI. Potential mechanisms. , 1995, Circulation.

[6]  Michael Bateman,et al.  MRI assessment of pacing induced ventricular dyssynchrony in an isolated human heart , 2010, Journal of Magnetic Resonance Imaging.

[7]  E A Krupinski,et al.  Usefulness of segmented trueFISP cardiac pulse sequence in evaluation of congenital and acquired adult cardiac abnormalities. , 2001, AJR. American journal of roentgenology.

[8]  E. McVeigh MRI of myocardial function: motion tracking techniques. , 1996, Magnetic resonance imaging.

[9]  E. McVeigh,et al.  Cardiac Tagging with Breath‐Hold Cine MRI , 1992, Magnetic resonance in medicine.

[10]  V. Wedeen,et al.  Diffusion Tensor Magnetic Resonance Imaging Mapping the Fiber Architecture Remodeling in Human Myocardium After Infarction: Correlation With Viability and Wall Motion , 2006, Circulation.

[11]  Michael Jerosch-Herold,et al.  Feedback‐assisted three‐dimensional reconstruction of the left ventricle with MRI , 2003, Journal of magnetic resonance imaging : JMRI.

[12]  R. Kim,et al.  Relationship of contractile function to transmural extent of infarction in patients with chronic coronary artery disease. , 2003, Journal of the American College of Cardiology.

[13]  K Uğurbil,et al.  Fast anatomical imaging of the heart and assessment of myocardial perfusion with arrhythmia insensitive magnetization preparation , 1995, Magnetic resonance in medicine.

[14]  M. Lazebnik,et al.  Safe magnetic resonance imaging scanning of patients with cardiac rhythm devices: a role for computer modeling. , 2013, Heart rhythm.

[15]  R. Slutsky,et al.  Tissue distribution and magnetic resonance spin lattice relaxation effects of gadolinium-DTPA. , 1985, Radiology.

[16]  Ergin Atalar,et al.  MRI‐guided coronary catheterization and PTCA: A feasibility study on a dog model , 2003, Magnetic resonance in medicine.

[17]  F. Prato,et al.  Measurement of the extraction efficiency and distribution volume for Gd‐DTPA in normal and diseased canine myocardium , 1993, Magnetic resonance in medicine.

[18]  R. Kim,et al.  Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing. , 2000, Journal of the American College of Cardiology.

[19]  Mirza Faisal Beg,et al.  Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging , 2005, Annals of the New York Academy of Sciences.

[20]  D. Duprez,et al.  Heterogeneous remodelling of the ascending and descending aorta with age , 2007, Journal of Human Hypertension.

[21]  E. Atalar,et al.  Magnetic Resonance Imaging Permits In Vivo Monitoring of Catheter-Based Vascular Gene Delivery , 2001, Circulation.

[22]  Peter Hunold,et al.  Magnetic resonance imaging in patients with a pacemaker system designed for the magnetic resonance environment. , 2011, Heart rhythm.

[23]  G M Hutchins,et al.  Two‐dimensional Echocardiography and Infarct Size: Relationship of Regional Wall Motion and Thickening to the Extent of Myocardial Infarction in the Dog , 1981, Circulation.

[24]  C. Starmer,et al.  Indicator Transit Time Considered as a Gamma Variate , 1964, Circulation research.

[25]  Kanishka Ratnayaka,et al.  A deflectable guiding catheter for real‐time MRI‐guided interventions , 2012, Journal of magnetic resonance imaging : JMRI.

[26]  Robert C. Susil,et al.  RF safety of wires in interventional MRI: Using a safety index , 2002 .

[27]  A de Roos,et al.  Left ventricular wall motion analysis in patients with acute myocardial infarction using magnetic resonance imaging. , 1993, Magnetic resonance imaging.

[28]  E R McVeigh,et al.  Segmented K-space cine breath-hold cardiovascular MR imaging: Part 1. Principles and technique. , 1997, AJR. American journal of roentgenology.

[29]  Michael Jerosch-Herold,et al.  VENTRICULAR FUNCTION Evaluation of Myocardial Volume Heterogeneity During End-Diastole and End-Systole Using Cine MRI , 2004 .

[30]  M. Cerqueira,et al.  Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. , 2002, Circulation.

[31]  P. Hunter,et al.  Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dog. , 1995, The American journal of physiology.

[32]  E. Sallin Fiber orientation and ejection fraction in the human left ventricle. , 1969, Biophysical journal.

[33]  Sheng-Kwei Song,et al.  Remodeling of cardiac fiber structure after infarction in rats quantified with diffusion tensor MRI. , 2003, American journal of physiology. Heart and circulatory physiology.

[34]  G. Hindricks,et al.  Catheter Ablation Guided by Real-Time MRI , 2014, Current Cardiology Reports.

[35]  Richard D. White,et al.  Segmentation of non-viable myocardium in delayed enhancement magnetic resonance images , 2005, The International Journal of Cardiovascular Imaging.

[36]  Daniel B Ennis,et al.  Device artifact reduction for magnetic resonance imaging of patients with implantable cardioverter-defibrillators and ventricular tachycardia: late gadolinium enhancement correlation with electroanatomic mapping. , 2014, Heart rhythm.

[37]  C J Hardy,et al.  Real‐time interactive MRI on a conventional scanner , 1997, Magnetic resonance in medicine.

[38]  E Fleck,et al.  Improvement of myocardial perfusion reserve early after coronary intervention: assessment with cardiac magnetic resonance imaging. , 2000, Journal of the American College of Cardiology.

[39]  J Paul Finn,et al.  Left ventricular mass: manual and automatic segmentation of true FISP and FLASH cine MR images in dogs and pigs. , 2004, Radiology.

[40]  E. Kanal,et al.  Impact of the Advisa MRI pacing system on the diagnostic quality of cardiac MR images and contraction patterns of cardiac muscle during scans: Advisa MRI randomized clinical multicenter study results. , 2013, Heart rhythm.

[41]  G L Wolf,et al.  Relaxation of water protons in the intra‐ and extracellular regions of blood containing Gd(DTPA) , 1986, Magnetic resonance in medicine.

[42]  P A Bottomley,et al.  High resolution intravascular MRI and MRS by using a catheter receiver coil , 1996, Magnetic resonance in medicine.

[43]  J. Zhang,et al.  Reconstruction of Cardiac Ventricular Geometry and Fiber Orientation Using Magnetic Resonance Imaging , 2000, Annals of Biomedical Engineering.

[44]  R L Winslow,et al.  Direct histological validation of diffusion tensor MRI in formaldehyde‐fixed myocardium , 2000, Magnetic resonance in medicine.

[45]  E. Braunwald Heart Disease: A Textbook of Cardiovascular Medicine , 1992, Annals of Internal Medicine.

[46]  N. Wilke,et al.  Analysis of myocardial perfusion MRI , 2004, Journal of magnetic resonance imaging : JMRI.

[47]  O. Simonetti,et al.  Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. , 1999, Circulation.

[48]  D. H. Campen,et al.  Optimization of Cardiac Fiber Orientation for Homogeneous Fiber Strain During Ejection , 1999, Annals of Biomedical Engineering.

[49]  D Franklin,et al.  Dynamic changes in left ventricular wall thickness and their use in analyzing cardiac function in the conscious dog. , 1976, The American journal of cardiology.

[50]  S. Nelson,et al.  Evaluation of left ventricular volume and mass with breath-hold cine MR imaging. , 1993, Radiology.

[51]  H Azhari,et al.  A noninvasive comparative study of myocardial strains in ischemic canine hearts using tagged MRI in 3-D. , 1995, The American journal of physiology.

[52]  W. Nitz,et al.  On the heating of linear conductive structures as guide wires and catheters in interventional MRI , 2001, Journal of magnetic resonance imaging : JMRI.

[53]  G. Hindricks,et al.  Three-dimensional real-time MRI-guided intracardiac catheter navigation. , 2014, European heart journal.

[54]  M. Saeed,et al.  MR fluoroscopy in vascular and cardiac interventions (review) , 2011, The International Journal of Cardiovascular Imaging.

[55]  E. E. van der Wall,et al.  Quantitative analysis of cardiovascular MR images , 1997, The International Journal of Cardiac Imaging.

[56]  R. Dinsmore,et al.  Imaging myocardial fiber architecture in vivo with magnetic resonance , 1995, Magnetic resonance in medicine.

[57]  Stephan G Nekolla,et al.  Assessment of coronary flow reserve: comparison between contrast-enhanced magnetic resonance imaging and positron emission tomography. , 2002, Journal of the American College of Cardiology.

[58]  F. Sheehan,et al.  Early recovery of left ventricular function after thrombolytic therapy for acute myocardial infarction: an important determinant of survival. , 1988, Journal of the American College of Cardiology.

[59]  P. Marino,et al.  Effect of streptokinase on left ventricular modeling and function after myocardial infarction: the GISSI (Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico) Trial. , 1989, Journal of the American College of Cardiology.

[60]  L. Younes,et al.  Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure , 2005, Magnetic resonance in medicine.

[61]  Michael Jerosch-Herold,et al.  Direct comparison of an intravascular and an extracellular contrast agent for quantification of myocardial perfusion , 1999, The International Journal of Cardiac Imaging.

[62]  U. Sechtem,et al.  Comparison of low-dose dobutamine-gradient-echo magnetic resonance imaging and positron emission tomography with [18F]fluorodeoxyglucose in patients with chronic coronary artery disease. A functional and morphological approach to the detection of residual myocardial viability. , 1995, Circulation.

[63]  Guang-Zhong Yang,et al.  Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. , 2002, The New England journal of medicine.

[64]  E. Fleck,et al.  Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. , 1999, Circulation.

[65]  U. Sechtem,et al.  MRI assessment of myocardial viability: comparison with other imaging techniques. , 1999, Rays.

[66]  F W Prinzen,et al.  Transmural gradients of cardiac myofiber shortening in aortic valve stenosis patients using MRI tagging. , 2002, American journal of physiology. Heart and circulatory physiology.

[67]  H W Woo,et al.  Advantages and applications of the centerline method for characterizing regional ventricular function. , 1986, Circulation.

[68]  R. Kim,et al.  Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study , 2003, The Lancet.

[69]  Albert C. Lardo,et al.  Real-Time Magnetic Resonance Imaging: Diagnostic and Interventional Applications , 2000, Pediatric Cardiology.

[70]  E. Erdmann,et al.  Comparison of dobutamine transesophageal echocardiography and dobutamine magnetic resonance imaging for detection of residual myocardial viability. , 1996, The American journal of cardiology.

[71]  Jerry L Prince,et al.  Visualizing myocardial function using HARP MRI. , 2000, Physics in medicine and biology.

[72]  C. Henriquez,et al.  Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation. , 1998, American journal of physiology. Heart and circulatory physiology.

[73]  H Calkins,et al.  Visualization and temporal/spatial characterization of cardiac radiofrequency ablation lesions using magnetic resonance imaging. , 2000, Circulation.

[74]  Robert J. Lederman,et al.  Interventional cardiovascular magnetic resonance imaging: a new opportunity for image-guided interventions. , 2009, JACC. Cardiovascular imaging.

[75]  Peter Boesiger,et al.  Cardiac real‐time imaging using SENSE , 2000 .

[76]  E. McVeigh,et al.  Effects of single- and biventricular pacing on temporal and spatial dynamics of ventricular contraction. , 2002, American journal of physiology. Heart and circulatory physiology.

[77]  E. M. Pedersen,et al.  Magnetic resonance imaging of blood velocity distribution around St. Jude medical aortic valves in patients. , 1996, The Journal of heart valve disease.

[78]  M. Penicka,et al.  Tissue doppler imaging predicts recovery of left ventricular function after recanalization of an occluded coronary artery. , 2004, Journal of the American College of Cardiology.

[79]  René M. Botnar,et al.  Assessment of prosthetic aortic valve performance by magnetic resonance velocity imaging , 2000, Magnetic Resonance Materials in Physics, Biology and Medicine.

[80]  N B Ingels,et al.  Myocardial fiber architecture and left ventricular function. , 1997, Technology and health care : official journal of the European Society for Engineering and Medicine.

[81]  O. Simonetti,et al.  The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. , 2000, The New England journal of medicine.

[82]  Christina E. Clarkson,et al.  Applications of magnetic resonance imaging for cardiac stem cell therapy. , 2004, Journal of interventional cardiology.

[83]  T. Parrish,et al.  Relationship of elevated 23Na magnetic resonance image intensity to infarct size after acute reperfused myocardial infarction. , 1999, Circulation.

[84]  B. Schnackenburg,et al.  Assessment of Myocardial Viability With Contrast-Enhanced Magnetic Resonance Imaging: Comparison With Positron Emission Tomography , 2002, Circulation.

[85]  C. Higgins,et al.  Thallium-like test for myocardial viability with MnDPDP-enhanced MRI. , 2002, Academic radiology.

[86]  Jerry L. Prince,et al.  Imaging heart motion using harmonic phase MRI , 2000, IEEE Transactions on Medical Imaging.

[87]  G. Sanz,et al.  Determinants of prognosis in survivors of myocardial infarction: a prospective clinical angiographic study. , 1982, The New England journal of medicine.

[88]  F. Rademakers,et al.  Importance of oblique fiber orientation for left ventricular wall deformation. , 1997, Technology and health care : official journal of the European Society for Engineering and Medicine.

[89]  D. H. Campen,et al.  Optimization of cardiac fiber orientation for homogeneous fiber strain at beginning of ejection. , 1997, Journal of biomechanics.

[90]  Paul A Iaizzo,et al.  Ex vivo diffusion tensor MRI of human hearts: Relative effects of specimen decomposition , 2012, Magnetic resonance in medicine.

[91]  R. Pettigrew Dynamic cardiac MR imaging. Techniques and applications. , 1989, Radiologic clinics of North America.

[92]  W. J. Hedley,et al.  Left ventricular mass and volume: fast calculation with guide-point modeling on MR images. , 2000, Radiology.

[93]  P. V. van Dijkman,et al.  Quantitative analysis of regional left ventricular function after myocardial infarction in the pig assessed with cine magnetic resonance imaging , 1995, Magnetic resonance in medicine.

[94]  F. Prato,et al.  The partition coefficient of Gd-DTPA reflects maintained tissue viability in a canine model of chronic significant coronary stenosis. , 2004, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

[95]  John Forder,et al.  Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging. , 1998, American journal of physiology. Heart and circulatory physiology.

[96]  Timothy G Reese,et al.  Combined diffusion and strain MRI reveals structure and function of human myocardial laminar sheets in vivo , 2003, Magnetic resonance in medicine.

[97]  G. Buckberg,et al.  The effect of ventricular sequential contraction on helical heart during pacing: high septal pacing versus biventricular pacing. , 2006, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[98]  Olga Bondarenko,et al.  Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. , 2003, Journal of the American College of Cardiology.

[99]  S. Solomon,et al.  Noninvasive assessment of left ventricular remodeling: concepts, techniques, and implications for clinical trials. , 2002, Journal of cardiac failure.

[100]  Katherine C. Wu,et al.  Accuracy of Contrast-Enhanced Magnetic Resonance Imaging in Predicting Improvement of Regional Myocardial Function in Patients After Acute Myocardial Infarction , 2002, Circulation.

[101]  O. Simonetti,et al.  An improved MR imaging technique for the visualization of myocardial infarction. , 2001, Radiology.

[102]  E. Shapiro,et al.  Myocardial infarct expansion: recognition, significance and pathology. , 1991, The American journal of cardiology.

[103]  H. Oswald,et al.  Noninvasive detection of myocardial ischemia from perfusion reserve based on cardiovascular magnetic resonance. , 2000, Circulation.

[104]  L Axel,et al.  Circumferential Myocardial Shortening in the Normal Human Left Ventricle: Assessment by Magnetic Resonance Imaging Using Spatial Modulation of Magnetization , 1991, Circulation.

[105]  Junjie Chen,et al.  Image‐based models of cardiac structure in health and disease , 2010, Wiley interdisciplinary reviews. Systems biology and medicine.

[106]  T J Brady,et al.  Myocardial fiber shortening in humans: initial results of MR imaging. , 2000, Radiology.

[107]  Timothy G Reese,et al.  Diffusion tensor MRI of myocardial fibers and sheets: Correspondence with visible cut‐face texture , 2003, Journal of magnetic resonance imaging : JMRI.

[108]  M. Jerosch-Herold,et al.  Myocardial blood flow quantification with MRI by model-independent deconvolution. , 2002, Medical physics.

[109]  G. V. von Schulthess,et al.  Assessment of Myocardial Perfusion in Coronary Artery Disease by Magnetic Resonance: A Comparison With Positron Emission Tomography and Coronary Angiography , 2001, Circulation.

[110]  J Paul Finn,et al.  Accurate quantification of right ventricular mass at MR imaging by using cine true fast imaging with steady-state precession: study in dogs. , 2004, Radiology.

[111]  D Chien,et al.  Ultrafast imaging using gradient echoes. , 1991, Magnetic resonance quarterly.

[112]  Eckart Fleck,et al.  Functional MRI in ischemic heart disease based on detection of contraction abnormalities , 1999 .

[113]  Leon Axel,et al.  Global cardiac function using fast breath‐hold MRI: Validation of new acquisition and analysis techniques , 1997, Magnetic resonance in medicine.

[114]  G. Beller,et al.  Improved outcome after coronary bypass surgery in patients with ischemic cardiomyopathy and residual myocardial viability. , 1997, Circulation.

[115]  P. Basser,et al.  Estimation of the effective self-diffusion tensor from the NMR spin echo. , 1994, Journal of magnetic resonance. Series B.

[116]  B. Wilkoff,et al.  MRI in patients with cardiac implantable electronic devices , 2012, Expert review of medical devices.

[117]  E. McVeigh,et al.  Noninvasive measurement of transmural gradients in myocardial strain with MR imaging. , 1991, Radiology.

[118]  R. Edelman,et al.  Cineangiography of the heart in a single breath hold with a segmented turboFLASH sequence. , 1991, Radiology.

[119]  J. Kuijer,et al.  Quantification of regional contractile function after infarction: strain analysis superior to wall thickening analysis in discriminating infarct from remote myocardium. , 2001, Journal of the American College of Cardiology.

[120]  K K Kwong,et al.  Anisotropy of water diffusion in the myocardium of the rat. , 1994, Circulation research.

[121]  R J van der Geest,et al.  Quantification of Global and Regional Ventricular Function in Cardiac Magnetic Resonance Imaging , 2000, Topics in magnetic resonance imaging : TMRI.

[122]  J L Boxerman,et al.  Segmented K-space cine breath-hold cardiovascular MR imaging: Part 2. Evaluation of aortic vasculopathy. , 1997, AJR. American journal of roentgenology.

[123]  L. Axel,et al.  Regional heart wall motion: two-dimensional analysis and functional imaging with MR imaging. , 1992, Radiology.

[124]  M Schwaiger,et al.  Preoperative positron emission tomographic viability assessment and perioperative and postoperative risk in patients with advanced ischemic heart disease. , 1997, Journal of the American College of Cardiology.

[125]  Raimund Erbel,et al.  Towards real-time cardiovascular magnetic resonance guided transarterial CoreValve implantation: in vivo evaluation in swine , 2012, Journal of Cardiovascular Magnetic Resonance.

[126]  Damien Rohmer,et al.  Reconstruction and Visualization of Fiber and Laminar Structure in the Normal Human Heart from Ex Vivo Diffusion Tensor Magnetic Resonance Imaging (DTMRI) Data , 2007, Investigative radiology.

[127]  Michael Jerosch-Herold,et al.  Magnetic resonance imaging of myocardial contrast enhancement with MS‐325 and its relation to myocardial blood flow and the perfusion reserve , 2003, Journal of magnetic resonance imaging : JMRI.

[128]  J. Ross,et al.  Fiber Orientation in the Canine Left Ventricle during Diastole and Systole , 1969, Circulation research.

[129]  Gernot Plank,et al.  Tachycardia in Post-Infarction Hearts: Insights from 3D Image-Based Ventricular Models , 2013, PloS one.

[130]  Dipan J. Shah,et al.  Gadolinium Cardiovascular Magnetic Resonance Predicts Reversible Myocardial Dysfunction and Remodeling in Patients With Heart Failure Undergoing &bgr;-Blocker Therapy , 2003, Circulation.

[131]  Ming Li,et al.  Real‐time interactive MRI‐guided cardiac surgery: Aortic valve replacement using a direct apical approach , 2006, Magnetic resonance in medicine.

[132]  M. L. Wood,et al.  Motion‐insensitive, steady‐state free precession imaging , 1990, Magnetic resonance in medicine.

[133]  A P Yoganathan,et al.  Magnetic resonance velocity imaging: a new method for prosthetic heart valve study. , 1995, The Journal of heart valve disease.

[134]  W. J. Maclntyre,et al.  Prognosis of Patients With Left Ventricular Dysfunction, With and Without Viable Myocardium After Myocardial Infarction: Relative Efficacy of Medical Therapy and Revascularization , 1994, Circulation.

[135]  R J van der Geest,et al.  Quantification in cardiac MRI , 1999, Journal of magnetic resonance imaging : JMRI.