Tonotopic organization of human auditory cortex

The organization of tonotopic fields in human auditory cortex was investigated using functional magnetic resonance imaging. Subjects were presented with stochastically alternating multi-tone sequences in six different frequency bands, centered at 200, 400, 800, 1600, 3200, and 6400 Hz. Two mirror-symmetric frequency gradients were found extending along an anterior-posterior axis from a zone on the lateral aspect of Heschl's gyrus (HG), which responds preferentially to lower frequencies, toward zones posterior and anterior to HG that are sensitive to higher frequencies. The orientation of these two principal gradients is thus roughly perpendicular to HG, rather than parallel as previously assumed. A third, smaller gradient was observed in the lateral posterior aspect of the superior temporal gyrus. The results suggest close homologies between the tonotopic organization of human and nonhuman primate auditory cortex.

[1]  J. Kaas,et al.  Tonotopic organization, architectonic fields, and connections of auditory cortex in macaque monkeys , 1993, The Journal of comparative neurology.

[2]  J. Rauschecker,et al.  Processing of complex sounds in the macaque nonprimary auditory cortex. , 1995, Science.

[3]  Dave R. M. Langers,et al.  Representation of lateralization and tonotopy in primary versus secondary human auditory cortex , 2007, NeuroImage.

[4]  J. Rauschecker,et al.  Processing of band-passed noise in the lateral auditory belt cortex of the rhesus monkey. , 2004, Journal of neurophysiology.

[6]  R. Goebel,et al.  Mirror-Symmetric Tonotopic Maps in Human Primary Auditory Cortex , 2003, Neuron.

[7]  M. Merzenich,et al.  Representation of the cochlear partition of the superior temporal plane of the macaque monkey. , 1973, Brain research.

[8]  Thomas E. Nichols,et al.  Nonparametric permutation tests for functional neuroimaging: A primer with examples , 2002, Human brain mapping.

[9]  P. Morosan,et al.  Probabilistic Mapping and Volume Measurement of Human Primary Auditory Cortex , 2001, NeuroImage.

[10]  R. Burkard,et al.  The functional anatomy of the normal human auditory system: responses to 0.5 and 4.0 kHz tones at varied intensities. , 1999, Cerebral cortex.

[11]  D. Yves von Cramon,et al.  Is It Tonotopy after All? , 2002, NeuroImage.

[12]  J. Kaas,et al.  Subdivisions of auditory cortex and processing streams in primates. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Teemu Rinne,et al.  Functional Maps of Human Auditory Cortex: Effects of Acoustic Features and Attention , 2009, PloS one.

[14]  K. Scheffler,et al.  Tonotopic organization of the human auditory cortex as detected by BOLD-FMRI , 1998, Hearing Research.

[15]  D. Pandya,et al.  Architectonic analysis of the auditory‐related areas of the superior temporal region in human brain , 2007, The Journal of comparative neurology.

[16]  E. G. Jones,et al.  Tonotopic organization of auditory cortical fields delineated by parvalbumin immunoreactivity in macaque monkeys , 1997, The Journal of comparative neurology.

[17]  D. Bendor,et al.  Neural response properties of primary, rostral, and rostrotemporal core fields in the auditory cortex of marmoset monkeys. , 2008, Journal of neurophysiology.

[18]  J. Kaas,et al.  Architectonic identification of the core region in auditory cortex of macaques, chimpanzees, and humans , 2001, The Journal of comparative neurology.

[19]  G. Mangun,et al.  Tonotopy in human auditory cortex examined with functional magnetic resonance imaging , 1997, Human brain mapping.

[20]  N. Logothetis,et al.  Functional Imaging Reveals Numerous Fields in the Monkey Auditory Cortex , 2006, PLoS biology.

[21]  E. William Yund,et al.  Local landmark-based mapping of human auditory cortex , 2004, NeuroImage.

[22]  J. Kaas,et al.  Subdivisions and connections of auditory cortex in owl monkeys , 1992, The Journal of comparative neurology.

[23]  P. Morosan,et al.  Human Primary Auditory Cortex: Cytoarchitectonic Subdivisions and Mapping into a Spatial Reference System , 2001, NeuroImage.

[24]  M. Mishkin,et al.  Serial and parallel processing in rhesus monkey auditory cortex , 1997, The Journal of comparative neurology.

[25]  A. Dale,et al.  Tonotopic organization in human auditory cortex revealed by progressions of frequency sensitivity. , 2004, Journal of neurophysiology.

[26]  S. Clarke,et al.  Cytochrome Oxidase, Acetylcholinesterase, and NADPH-Diaphorase Staining in Human Supratemporal and Insular Cortex: Evidence for Multiple Auditory Areas , 1997, NeuroImage.

[27]  Peter Herscovitch,et al.  Tonotopic organization in human auditory cortex revealed by positron emission tomography , 1985, Hearing Research.

[28]  J. Rauschecker,et al.  Functional specialization of medial auditory belt cortex in the alert rhesus monkey. , 2009, Journal of neurophysiology.

[29]  Jeffrey R. Binder,et al.  Volumetric vs. surface-based alignment for localization of auditory cortex activation , 2005, NeuroImage.