Spongelike Porous Silica Nanosheets: From "Soft" Molecular Trapping to DNA Delivery.

Spongelike porous silica nanosheets, with nanometer thicknesses and pores whose diameters are on the hundreds-of-nanometers scale, have been used as a novel carrier for molecular immobilization of different guests. Enhanced properties of encapsulation were shown for drug molecules of different dimensions due to "softness" caused by the specific nanometric features of the porous structure. The encapsulating effect of the structure results in sustained and stimuli-responsive release behavior of immobilized guest molecules. By studying the adsorption process of DNA molecules on spongelike porous nanosheets or on solid nanoparticles by use of a quartz crystal microbalance, we show that better elasticity of surfaces of the porous nanosheets over that of solid nanoparticles can improve the immobilization of guest molecules. The coating of porous silica nanosheets onto various substrates was also found to effectively mediate DNA delivery to mammalian cells.

[1]  Katsuhiko Ariga,et al.  Flake-shell capsules: adjustable inorganic structures. , 2012, Small.

[2]  N. K. Jain,et al.  Dextran conjugated dendritic nanoconstructs as potential vectors for anti-cancer agent. , 2009, Biomaterials.

[3]  William R. Dichtel,et al.  Multivalent binding motifs for the noncovalent functionalization of graphene. , 2011, Journal of the American Chemical Society.

[4]  Katsuhiko Ariga,et al.  Manipulation of shell morphology of silicate spheres from structural evolution in a purely inorganic system. , 2015, Chemistry, an Asian journal.

[5]  Jianlin Shi,et al.  Hollow‐Structured Mesoporous Materials: Chemical Synthesis, Functionalization and Applications , 2014, Advanced materials.

[6]  Jianping Fu,et al.  Fluorescent porous carbon nanocapsules for two-photon imaging, NIR/pH dual-responsive drug carrier, and photothermal therapy. , 2015, Biomaterials.

[7]  Tawfik A. Saleh,et al.  Sorption of pollutants by porous carbon, carbon nanotubes and fullerene- An overview , 2013, Environmental Science and Pollution Research.

[8]  Cecilia Sahlgren,et al.  Mesoporous silica nanoparticles in medicine--recent advances. , 2013, Advanced drug delivery reviews.

[9]  Katsuhiko Ariga,et al.  Bioactive flake-shell capsules: soft silica nanoparticles for efficient enzyme immobilization. , 2013, Journal of materials chemistry. B.

[10]  K. Barick,et al.  Nanoscale assembly of mesoporous ZnO: A potential drug carrier , 2010 .

[11]  C. Chignell,et al.  Photophysical and Photochemical Studies of 2-Phenylbenzimidazole and UVB Sunscreen 2-Phenylbenzimidazole-5-sulfonic Acid¶ , 2002 .

[12]  Katsuhiko Ariga,et al.  Inorganic Nanoarchitectonics for Biological Applications , 2012 .

[13]  Albert Rimola,et al.  Silica surface features and their role in the adsorption of biomolecules: computational modeling and experiments. , 2013, Chemical reviews.

[14]  George G. Guilbault,et al.  Commercial quartz crystal microbalances-Theory and applications , 1999 .

[15]  S. Yamago,et al.  Size-selective encapsulation of C60 by [10]cycloparaphenylene: formation of the shortest fullerene-peapod. , 2011, Angewandte Chemie.

[16]  Jingwen Chen,et al.  Quantum chemical investigation and experimental verification on the aquatic photochemistry of the sunscreen 2-phenylbenzimidazole-5-sulfonic acid. , 2010, Environmental science & technology.

[17]  Katsuhiko Ariga,et al.  Electrochemical nanoarchitectonics and layer-by-layer assembly: From basics to future , 2015 .

[18]  F. Babonneau,et al.  Order−Disorder Transitions and Evolution of Silica Structure in Self-Assembled Mesostructured Silica Films Studied through FTIR Spectroscopy , 2003 .

[19]  Vikas Varshney,et al.  Prediction of specific biomolecule adsorption on silica surfaces as a function of pH and particle size , 2014 .

[20]  Katsuhiko Ariga,et al.  Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α , 2012, International journal of nanomedicine.

[21]  Eric C. Carnes,et al.  Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. , 2013, Accounts of chemical research.

[22]  M. McGuire,et al.  ATR-FTIR observations of water structure in colloidal silica: implications for the hydration force mechanism. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[23]  Gérard Férey,et al.  Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. , 2010, Nature materials.

[24]  Huichao Chen,et al.  High efficiency immobilization of sulfur on nitrogen-enriched mesoporous carbons for Li-S batteries. , 2013, ACS applied materials & interfaces.

[25]  Fan Zhang,et al.  Lab on Upconversion Nanoparticles: Optical Properties and Applications Engineering via Designed Nanostructure , 2015 .

[26]  Katsuhiko Ariga,et al.  Silica-based gene reverse transfection: an upright nanosheet network for promoted DNA delivery to cells. , 2012, Chemical communications.

[27]  施剑林.  Sub-150 nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation , 2013 .

[28]  Juan L. Vivero-Escoto,et al.  Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. , 2008, Advanced drug delivery reviews.

[29]  Xuebin Wang,et al.  Highly water-soluble, porous, and biocompatible boron nitrides for anticancer drug delivery. , 2014, ACS nano.

[30]  Kai Liu,et al.  Host-enhanced π-π interaction for water-soluble supramolecular polymerization. , 2011, Chemistry.

[31]  Xianghong Liu,et al.  Nanostructured Materials for Room‐Temperature Gas Sensors , 2016, Advanced materials.

[32]  A. Cooper,et al.  Separation of rare gases and chiral molecules by selective binding in porous organic cages. , 2014, Nature materials.

[33]  F. Bertin,et al.  Infrared spectroscopic ellipsometry for residual water detection in annealed sol–gel thin layers , 1998 .

[34]  Katsuhiko Ariga,et al.  Supramolecular approaches to biological therapy , 2009, Expert opinion on biological therapy.

[35]  Mohamed Ismael,et al.  Trace copper(II) ions detection and removal from water using novel ligand modified composite adsorbent , 2013 .

[36]  Katsuhiko Ariga,et al.  Gene transfer on inorganic/organic hybrid silica nanosheets. , 2015, Physical chemistry chemical physics : PCCP.

[37]  Katsuhiko Ariga,et al.  Nanoarchitectonics for Dynamic Functional Materials from Atomic‐/Molecular‐Level Manipulation to Macroscopic Action , 2016, Advanced materials.

[38]  Weiguang Dong,et al.  Transporting a tube in a tube. , 2014, Nano letters.

[39]  B. Herzog.  Photoprotection of human skin , 2012 .

[40]  I. Smirnova,et al.  Polysaccharide-based aerogels—Promising biodegradable carriers for drug delivery systems , 2011 .

[41]  Katsuhiko Ariga,et al.  Nanosheet transfection: effective transfer of naked DNA on silica glass , 2015 .

[42]  Ying-Jie Zhu,et al.  Hydroxyapatite nanosheet-assembled porous hollow microspheres: DNA-templated hydrothermal synthesis, drug delivery and protein adsorption , 2012 .

[43]  R. Martínez‐Máñez,et al.  Gated silica mesoporous supports for controlled release and signaling applications. , 2013, Accounts of chemical research.

[44]  M. Wong Chi Man,et al.  Mesoporous-Silica-Functionalized Nanoparticles for Drug Delivery. , 2015, Chemistry.

[45]  Xiaohong Sun,et al.  Nanocasting synthesis of In2O3 with appropriate mesostructured ordering and enhanced gas-sensing property. , 2014, ACS applied materials & interfaces.

[46]  R. Gschwind,et al.  Tunable Porosities and Shapes of Fullerene-Like Spheres , 2015, Chemistry.

[47]  K. Ariga,et al.  Highly ordered nanoporous carbon films with tunable pore diameters and their excellent sensing properties. , 2015, Chemistry.

[48]  Gang Zhang,et al.  Organic Cage Compounds — From Shape-Persistency to Function , 2014 .

[49]  Yi Wang,et al.  Imparting functionality to a metal-organic framework material by controlled nanoparticle encapsulation. , 2012, Nature chemistry.

[50]  H. Möhwald,et al.  Stimuli-responsive LbL capsules and nanoshells for drug delivery. , 2011, Advanced drug delivery reviews.

[51]  M. Burghammer,et al.  Sponge-like nanoporous single crystals of gold , 2015, Nature Communications.