Melting the Iceberg: Contrast Invariance in Visual Cortex

Neurons in visual cortex maintain their selectivity for stimulus orientation despite wide variations in stimulus contrast. Achieving this invariance is a challenge because of the iceberg effect: subthreshold responses are broader in selectivity than firing responses, and increasing contrast would bring them above threshold. An article in this issue of Neuron by Finn et al. explains how neurons solve this problem using simple mechanisms: contrast-gain control, additive noise, and firing threshold.

[1]  D. Heeger Half-squaring in responses of cat striate cells , 1992, Visual Neuroscience.

[2]  E. Bizzi,et al.  The Cognitive Neurosciences , 1996 .

[3]  M. Carandini Amplification of Trial-to-Trial Response Variability by Neurons in Visual Cortex , 2004, PLoS biology.

[4]  C. Blakemore,et al.  Effects of bicuculline on functions of inhibition in visual cortex , 1974, Nature.

[5]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[6]  D. Wilkin,et al.  Neuron , 2001, Brain Research.

[7]  K. Miller,et al.  Different Roles for Simple-Cell and Complex-Cell Inhibition in V1 , 2003, The Journal of Neuroscience.

[8]  D. Ferster,et al.  Neural mechanisms of orientation selectivity in the visual cortex. , 2000, Annual review of neuroscience.

[9]  Nicholas J. Priebe,et al.  The Emergence of Contrast-Invariant Orientation Tuning in Simple Cells of Cat Visual Cortex , 2007, Neuron.

[10]  H. Sompolinsky,et al.  Theory of orientation tuning in visual cortex. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[11]  S. Nelson,et al.  An emergent model of orientation selectivity in cat visual cortical simple cells , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[12]  D. Ferster,et al.  The contribution of noise to contrast invariance of orientation tuning in cat visual cortex. , 2000, Science.

[13]  L. Cosmides From : The Cognitive Neurosciences , 1995 .

[14]  D. Heeger Normalization of cell responses in cat striate cortex , 1992, Visual Neuroscience.

[15]  K. Miller,et al.  LGN input to simple cells and contrast-invariant orientation tuning: an analysis. , 2002, Journal of neurophysiology.

[16]  M. Carandini,et al.  Membrane Potential and Firing Rate in Cat Primary Visual Cortex , 2000, The Journal of Neuroscience.

[17]  I. Ohzawa,et al.  The effects of contrast on visual orientation and spatial frequency discrimination: a comparison of single cells and behavior. , 1987, Journal of neurophysiology.

[18]  D. Ferster,et al.  Strength and Orientation Tuning of the Thalamic Input to Simple Cells Revealed by Electrically Evoked Cortical Suppression , 1998, Neuron.

[19]  R. Rosenfeld Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[20]  Nicholas J. Priebe,et al.  Contrast-Invariant Orientation Tuning in Cat Visual Cortex: Thalamocortical Input Tuning and Correlation-Based Intracortical Connectivity , 1998, The Journal of Neuroscience.