Exploring the genetic architecture of inflammatory bowel disease by whole genome sequencing identifies association at ADCY7
暂无分享,去创建一个
Tariq Ahmad | Loukas Moutsianas | Alison Simmons | Joshua Randall | David C. Wilson | Carl A. Anderson | Jack Satsangi | Shane McCarthy | Luke Jostins | Charlie W. Lees | Miles Parkes | Christopher G. Mathew | William G. Newman | Ailsa Hart | Jeffrey C. Barrett | James C. Lee | Mark Tremelling | Natalie J. Prescott | John C. Mansfield | Cathryn Edwards | Craig Mowat | Yang Luo | Katrina M. de Lange | Nicholas A. Kennedy | Christopher A. Lamb | Eva Goncalves Serra | Chris Hawkey | Sam Nichols | Martin Pollard | Holm Uhlig
[1] Masa Umicevic Mirkov,et al. Association mapping of inflammatory bowel disease loci to single variant resolution , 2015, bioRxiv.
[2] Judy H. Cho,et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations , 2015, Nature Genetics.
[3] Judy H. Cho,et al. Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis , 2013, PLoS genetics.
[4] Joshua M. Korn,et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease , 2011, Nature Genetics.
[5] R. Handsaker,et al. Large multi-allelic copy number variations in humans , 2015, Nature Genetics.
[6] Laura J. Scott,et al. A reference panel of 64,976 haplotypes for genotype imputation , 2015, bioRxiv.
[7] Constantin Polychronakos,et al. Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases , 2016 .
[8] P. Visscher,et al. GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.
[9] Tom R. Gaunt,et al. The UK10K project identifies rare variants in health and disease , 2016 .
[10] M. Daly,et al. Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants , 2014, Nature.
[11] Dorothy Yuan,et al. Distinct Roles of Adenylyl Cyclase VII in Regulating the Immune Responses in Mice , 2010, The Journal of Immunology.
[12] D. MacArthur,et al. Negligible impact of rare autoimmune-locus coding-region variants on missing heritability , 2013, Nature.
[13] Warren W. Kretzschmar,et al. Sparse whole genome sequencing identifies two loci for major depressive disorder , 2015, Nature.
[14] D. Absher,et al. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. , 2014, Human molecular genetics.
[15] J. Turner,et al. Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA* , 2012, Inflammatory bowel diseases.
[16] Terrence S. Furey,et al. The UCSC Genome Browser Database: update 2006 , 2005, Nucleic Acids Res..
[17] P. Visscher,et al. Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data. , 2014, Human molecular genetics.
[18] Jennifer Mulle,et al. A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci , 2012, PLoS genetics.
[19] T. Meehan,et al. An atlas of active enhancers across human cell types and tissues , 2014, Nature.
[20] Minna Männikkö,et al. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders , 2016, Nature Neuroscience.
[21] Eric S. Lander,et al. A polygenic burden of rare disruptive mutations in schizophrenia , 2014, Nature.
[22] G. Abecasis,et al. Low-coverage sequencing: implications for design of complex trait association studies. , 2011, Genome research.
[23] Tariq Ahmad,et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 , 2011, Nature Genetics.
[24] P. Donnelly,et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region , 2010 .
[25] B. Browning,et al. Improving the Accuracy and Efficiency of Identity-by-Descent Detection in Population Data , 2013, Genetics.
[26] T. Eschenhagen,et al. Capturing adenylyl cyclases as potential drug targets , 2009, Nature Reviews Drug Discovery.
[27] Alastair Forbes,et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility , 2007, Nature Genetics.
[28] Simon C. Potter,et al. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.
[29] David C. Wilson,et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.
[30] P. Sternweis,et al. Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation. , 2013, Molecular immunology.
[31] M. Daly,et al. Searching for missing heritability: Designing rare variant association studies , 2014, Proceedings of the National Academy of Sciences.
[32] Andriy Derkach,et al. Association analysis using next-generation sequence data from publicly available control groups: the robust variance score statistic , 2014, Bioinform..
[33] Andrew J. Hill,et al. Analysis of protein-coding genetic variation in 60,706 humans , 2015, bioRxiv.
[34] G. Valen,et al. Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression. , 2015, Human immunology.
[35] A. Aasen,et al. Effects of Forskolin on Kupffer Cell Production of Interleukin-10 and Tumor Necrosis Factor Alpha Differ from Those of Endogenous Adenylyl Cyclase Activators: Possible Role for Adenylyl Cyclase 9 , 2005, Infection and Immunity.
[36] Christopher S. Poultney,et al. Synaptic, transcriptional, and chromatin genes disrupted in autism , 2014, Nature.
[37] M. Daly,et al. Subtle stratification confounds estimates of heritability from rare variants , 2016, bioRxiv.
[38] M. DePristo,et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. , 2010, Genome research.
[39] Todd A. Johnson,et al. A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. , 2013, Gastroenterology.
[40] T. Spector,et al. GENOME-WIDE ASSOCIATION ANALYSES BASED ON WHOLE-GENOME SEQUENCING IN SARDINIA PROVIDE INSIGHTS INTO REGULATION OF HEMOGLOBIN LEVELS , 2015, Nature Genetics.
[41] David M. Herrington,et al. Multiple rare alleles at LDLR and APOA5 confer risk for early-onset myocardial infarction , 2014, Nature.
[42] Doug Speed,et al. MultiBLUP: improved SNP-based prediction for complex traits , 2014, Genome research.
[43] Richard Durbin,et al. Efficient haplotype matching and storage using the positional Burrows–Wheeler transform (PBWT) , 2014, Bioinform..
[44] J. Barrett,et al. Pooled Sequencing of 531 Genes in Inflammatory Bowel Disease Identifies an Associated Rare Variant in BTNL2 and Implicates Other Immune Related Genes , 2015, PLoS Genetics.
[45] Yusun Jung,et al. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations , 2013, Gut.
[46] Judy H. Cho,et al. Finding the missing heritability of complex diseases , 2009, Nature.