The deactivation network in brain during acute stress

There is growing evidence from patient and psychoneuroimmunology studies that there is a clear correlation between the psychosocial stress and health state, but the neural mechanism of the correlation remain poorly understood. The deactivations of the limbic system and anterior frontal cortex during acute psychosocial stress were reported in recent studies, and the observed results suggest these brain areas are activated at rest and during nonstressful situations suggesting the deactivation regions during stress play an important role in detrimental health effects of psychosocial stress. However, these studies mostly aim at confining the brain regions that present the decrease of the brain blood flow. The response mode and space-time relation of these regions from overall and dynamic angle are left untouched. In this paper, we exposed human subjects to one mathematic stressor and one comparison task in one functional magnetic resonance imaging (fMRI; n = 17) experiment and one of the regions of interest (ROIs)-based functional connectivity analyses, within-condition interregional covariance analysis (WICA), is employed to analyze the interaction of the brain regions that show deactivation during different task states. We demonstrate a profound deactivation of limbic system and anterior frontal cortex during mathematic stress and a neural network of deactivation regions, which was modulated by the difficult degree of mathematic tasks.

[1]  A. Alavi,et al.  The measurement of regional cerebral blood flow during the complex cognitive task of meditation: a preliminary SPECT study , 2001, Psychiatry Research: Neuroimaging.

[2]  F. Gage,et al.  More hippocampal neurons in adult mice living in an enriched environment , 1997, Nature.

[3]  J. Allman,et al.  Intuition and autism: a possible role for Von Economo neurons , 2005, Trends in Cognitive Sciences.

[4]  T. Furmark,et al.  Cerebral blood flow during anticipation of public speaking in social phobia: a PET study , 2002, Biological Psychiatry.

[5]  Jens C. Pruessner,et al.  Deactivation of the Limbic System During Acute Psychosocial Stress: Evidence from Positron Emission Tomography and Functional Magnetic Resonance Imaging Studies , 2008, Biological Psychiatry.

[6]  R. Sapolsky Why Stress Is Bad for Your Brain , 1996, Science.

[7]  O. Wolf,et al.  HPA axis and memory. , 2003, Best practice & research. Clinical endocrinology & metabolism.

[8]  A. Deutman,et al.  Retinoic acid delays transcription of human retinal pigment neuroepithelium marker genes in ARPE‐19 cells , 2000, Neuroreport.

[9]  J. D. McGaugh,et al.  Role of adrenal stress hormones in forming lasting memories in the brain , 2002, Current Opinion in Neurobiology.

[10]  J. Detre,et al.  Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  A. Meltzoff,et al.  Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain , 2006, Neuropsychologia.

[12]  Peter T Fox,et al.  Modulation of neural connectivity during tongue movement and reading , 2003, Human brain mapping.

[13]  S. Lupien,et al.  The modulatory effects of corticosteroids on cognition: studies in young human populations , 2002, Psychoneuroendocrinology.

[14]  Kewei Chen,et al.  Arithmetic processing in the brain shaped by cultures. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[15]  G. Fricchione,et al.  Functional brain mapping of the relaxation response and meditation , 2000, Neuroreport.

[16]  T. Tabira,et al.  Chronic stress differentially regulates glucocorticoid negative feedback response in rats , 2001, Psychoneuroendocrinology.

[17]  Michael I. Posner,et al.  Analyzing and shaping human attentional networks , 2006, Neural Networks.

[18]  T. Shallice,et al.  Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. , 2003, Brain : a journal of neurology.

[19]  J. Decety,et al.  The functional architecture of human empathy. , 2004, Behavioral and cognitive neuroscience reviews.

[20]  E. Gould,et al.  Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation , 1997, The Journal of Neuroscience.

[21]  R. Sapolsky,et al.  Glucocorticoids, stress, and their adverse neurological effects: relevance to aging , 1999, Experimental Gerontology.