From genes to drugs: targeted strategies for melanoma
暂无分享,去创建一个
[1] G. Linette,et al. Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104) , 2012, Journal of Translational Medicine.
[2] S. Nelson,et al. Melanoma whole exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance , 2012, Nature Communications.
[3] K. Brown,et al. A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma , 2011, Nature.
[4] Tom Misteli,et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) , 2011, Nature.
[5] S. Puig,et al. A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma , 2011, Nature.
[6] K. Flaherty,et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[7] Axel Hoos,et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. , 2011, The New England journal of medicine.
[8] A. Hauschild,et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. , 2011, The New England journal of medicine.
[9] C. Antonescu,et al. KIT as a therapeutic target in metastatic melanoma. , 2011, JAMA.
[10] V. Sondak,et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. , 2011, Cancer research.
[11] C. Antonescu. The GIST paradigm: lessons for other kinase‐driven cancers , 2011, The Journal of pathology.
[12] S. Nelson,et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation , 2010, Nature.
[13] C. Der. Faculty Opinions recommendation of COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. , 2010 .
[14] Damien Kee,et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. , 2010, Cancer cell.
[15] A. Bowcock,et al. Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas , 2010, Science.
[16] K. Flaherty,et al. Inhibition of mutated, activated BRAF in metastatic melanoma. , 2010, The New England journal of medicine.
[17] D. Schadendorf,et al. Improved survival with ipilimumab in patients with metastatic melanoma. , 2010, The New England journal of medicine.
[18] H. Pehamberger,et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.
[19] K. Flaherty,et al. Safety and efficacy results from the first-in-human study of the oral MEK 1/2 inhibitor GSK1120212. , 2010 .
[20] M. Brown,et al. Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. , 2010 .
[21] M. Belvin,et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth , 2010, Nature.
[22] Chao Zhang,et al. RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF , 2010, Nature.
[23] W. Hahn,et al. An oncogenic role for ETV1 in melanoma. , 2010, Cancer research.
[24] D. Schadendorf,et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. , 2010, The Lancet. Oncology.
[25] J. Reis-Filho,et al. Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF , 2010, Cell.
[26] W. Sellers,et al. MEK1 mutations confer resistance to MEK and B-RAF inhibition , 2009, Proceedings of the National Academy of Sciences.
[27] Jimmy Lin,et al. Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4 , 2009, Nature Genetics.
[28] D. Fisher,et al. MITF pathway mutations in melanoma , 2009, Pigment cell & melanoma research.
[29] A. Hauschild,et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[30] G. Schwartz,et al. A phase I study of XL281, a selective oral RAF kinase inhibitor, in patients (Pts) with advanced solid tumors. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[31] Peng Xie,et al. The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase. , 2009, Biochemistry.
[32] J. Reis-Filho,et al. Oncogenic Braf induces melanocyte senescence and melanoma in mice. , 2009, Cancer cell.
[33] R. DePinho,et al. BRafV600E cooperates with Pten silencing to elicit metastatic melanoma , 2009, Nature Genetics.
[34] D. Elder,et al. CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations , 2009, Oncogene.
[35] J. Wolchok,et al. Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma , 2008, Clinical Cancer Research.
[36] J. Fletcher,et al. Imatinib Targeting of KIT-Mutant Oncoprotein in Melanoma , 2008, Clinical Cancer Research.
[37] E. Small,et al. Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[38] Susan Muller,et al. KIT Gene Mutations and Copy Number in Melanoma Subtypes , 2008, Clinical Cancer Research.
[39] J. Wolchok,et al. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. , 2008, The oncologist.
[40] Hong Wu,et al. Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E–mutated melanomas , 2008, Molecular Cancer Therapeutics.
[41] L. Poling,et al. Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage , 2008, Pigment cell & melanoma research.
[42] A. Hauschild,et al. Multicenter phase II trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma , 2008, Melanoma research.
[43] B. Bastian,et al. Dose‐dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation , 2008, Pigment cell & melanoma research.
[44] Helen Pickersgill,et al. Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF , 2008, PloS one.
[45] K. Flaherty,et al. Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. , 2008, Cancer research.
[46] D. Polsky,et al. Frequent p16-independent inactivation of p14ARF in human melanoma. , 2008, Journal of the National Cancer Institute.
[47] Shaomeng Wang,et al. Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer , 2008, Molecular Cancer Therapeutics.
[48] U. Keilholz. CTLA-4: Negative Regulator of the Immune Response and a Target for Cancer Therapy , 2008, Journal of immunotherapy.
[49] A. Testori,et al. Anti-CTLA4 monoclonal antibody Ipilimumab in the treatment of metastatic melanoma: recent findings. , 2008, Recent patents on anti-cancer drug discovery.
[50] P. Bycott,et al. Axitinib (AG-013736) in patients with metastatic melanoma: A phase II study , 2008 .
[51] R. Dummer,et al. AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: An open-label, randomized, multicenter, phase II study. , 2008 .
[52] David D. Smith,et al. Detection of Copy Number Alterations in Metastatic Melanoma by a DNA Fluorescence In situ Hybridization Probe Panel and Array Comparative Genomic Hybridization: A Southwest Oncology Group Study (S9431) , 2008, Clinical Cancer Research.
[53] Carlo Gambacorti-Passerini,et al. BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells , 2008, Molecular Cancer Research.
[54] A. D. Van den Abbeele,et al. Major response to imatinib mesylate in KIT-mutated melanoma. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[55] Kam Y. J. Zhang,et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity , 2008, Proceedings of the National Academy of Sciences.
[56] S. O’Day,et al. Targeting cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) , 2007, Cancer.
[57] P. Valent,et al. Comparison of a treatment strategy combining CCI-779 plus DTIC versus DTIC monotreatment in human melanoma in SCID mice. , 2007, The Journal of investigative dermatology.
[58] S. Zhang,et al. Review: dendritic cell-based vaccine in the treatment of patients with advanced melanoma. , 2007, Cancer biotherapy & radiopharmaceuticals.
[59] Paul D. Martin,et al. AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models , 2007, Molecular Cancer Therapeutics.
[60] M. Ringnér,et al. Genomic profiling of malignant melanoma using tiling-resolution arrayCGH , 2007, Oncogene.
[61] K. Wilner,et al. A phase I dose escalation trial of a daily oral CDK 4/6 inhibitor PD-0332991 , 2007 .
[62] Helen X. Chen,et al. A Randomized Phase 2 Trial of Bevacizumab with or without Daily Low-Dose Interferon Alfa-2b in Metastatic Malignant Melanoma , 2007, Annals of Surgical Oncology.
[63] N. Hayward,et al. Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays. , 2007, Cancer research.
[64] K. Flaherty,et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[65] N. Dhomen,et al. New insight into BRAF mutations in cancer. , 2007, Current opinion in genetics & development.
[66] Hieu T. Do,et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. , 2006, Cancer research.
[67] S. Wilhelm,et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer , 2006, Nature Reviews Drug Discovery.
[68] H. Ueno,et al. Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34+ progenitor-derived dendritic cells , 2006, Cancer Immunology, Immunotherapy.
[69] D. Pinkel,et al. Somatic activation of KIT in distinct subtypes of melanoma. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[70] D. Fisher,et al. MITF: master regulator of melanocyte development and melanoma oncogene. , 2006, Trends in molecular medicine.
[71] M. Ratain,et al. Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis , 2006, British Journal of Cancer.
[72] A. Joe,et al. Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy , 2006, Nature Clinical Practice Oncology.
[73] M. Hendrix,et al. Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness , 2006, Nature Medicine.
[74] G. Linette,et al. Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104) , 2006, Journal of Translational Medicine.
[75] L. Chin,et al. Amplification of CDK4 and MDM2 in malignant melanoma , 2006, Genes, chromosomes & cancer.
[76] Fernando Salangsang,et al. CHIR-265, a novel inhibitor that targets B-Raf and VEGFR, shows efficacy in a broad range of preclinical models , 2006 .
[77] J. Webster,et al. Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumors , 2006, BMC Cancer.
[78] Todd R. Golub,et al. BRAF mutation predicts sensitivity to MEK inhibition , 2006, Nature.
[79] J. Testa,et al. In vitro hypoxia-conditioned colon cancer cell lines derived from HCT116 and HT29 exhibit altered apoptosis susceptibility and a more angiogenic profile in vivo , 2005, British Journal of Cancer.
[80] Guang Yang,et al. Recurrent patterns of dual RB and p53 pathway inactivation in melanoma. , 2005, The Journal of investigative dermatology.
[81] P. Workman,et al. Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. , 2005, Cancer research.
[82] J. Fridlyand,et al. Distinct sets of genetic alterations in melanoma. , 2005, The New England journal of medicine.
[83] C. Slingluff,et al. Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin , 2005, Journal of Translational Medicine.
[84] Jean-Philippe Brunet,et al. The melanocyte differentiation program predisposes to metastasis after neoplastic transformation , 2005, Nature Genetics.
[85] Gang Li,et al. The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. , 2005, Frontiers in bioscience : a journal and virtual library.
[86] J. Shay,et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi , 2005, Nature.
[87] T. Golub,et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.
[88] Y. Kawakami,et al. Immunological detection of altered signaling molecules involved in melanoma development , 2005, Cancer and Metastasis Reviews.
[89] P. LoRusso,et al. A phase 1–2 clinical study of a second generation oral MEK inhibitor, PD 0325901 in patients with advanced cancer , 2005 .
[90] K. Flaherty,et al. Phase I/II, pharmacokinetic and pharmacodynamic trial of BAY 43–9006 alone in patients with metastatic melanoma , 2005 .
[91] J. Castro,et al. Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells , 2005, International journal of cancer.
[92] Rui Qiao,et al. Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild‐type INK4A in melanoma cells , 2005, International journal of cancer.
[93] R. Steinman,et al. Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients , 2005, The Journal of experimental medicine.
[94] E. Gilboa,et al. Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. , 2005, Blood.
[95] S. Sebti. Protein farnesylation: implications for normal physiology, malignant transformation, and cancer therapy. , 2005, Cancer cell.
[96] L. Zon,et al. BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma , 2005, Current Biology.
[97] S. Kato,et al. Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations , 2005, Human mutation.
[98] J. Schultze,et al. DCs and CD40-activated B cells: current and future avenues to cellular cancer immunotherapy. , 2004, Trends in immunology.
[99] S. Venuta,et al. Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. , 2004, European journal of cancer.
[100] T. Golub,et al. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. , 2004, Cancer cell.
[101] J. Cheng,et al. Deregulated Akt3 Activity Promotes Development of Malignant Melanoma , 2004, Cancer Research.
[102] D. Auclair,et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis , 2004, Cancer Research.
[103] C. Marshall,et al. B-RAF is a therapeutic target in melanoma , 2004, Oncogene.
[104] K. Taira,et al. Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference , 2004, Oncogene.
[105] M. Pierotti,et al. BRAF alterations are associated with complex mutational profiles in malignant melanoma , 2004, Oncogene.
[106] G. Freeman,et al. PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. , 2004, Cellular immunology.
[107] M. Ratain,et al. Preliminary antitumor activity of BAY 43-9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT). , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[108] G. Freeman,et al. CD4 CD25 T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion , 2004 .
[109] C. Springer,et al. V599EB-RAF is an Oncogene in Melanocytes , 2004, Cancer Research.
[110] F. Haluska,et al. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. , 2004, The Journal of investigative dermatology.
[111] V. Engelhard,et al. Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[112] V. Engelhard,et al. Route of Immunization with Peptide-pulsed Dendritic Cells Controls the Distribution of Memory and Effector T Cells in Lymphoid Tissues and Determines the Pattern of Regional Tumor Control , 2003, The Journal of experimental medicine.
[113] D. Neuberg,et al. Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[114] D. Tuveson,et al. Suppression of BRAF(V599E) in human melanoma abrogates transformation. , 2003, Cancer research.
[115] A. Potti,et al. Immunohistochemical determination of vascular endothelial growth factor (VEGF) overexpression in malignant melanoma. , 2003, Anticancer research.
[116] D. Gabrilovich,et al. Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species , 2003, Journal of leukocyte biology.
[117] D. Stupack,et al. Role of Raf in Vascular Protection from Distinct Apoptotic Stimuli , 2003, Science.
[118] A. Krieg. CpG motifs: the active ingredient in bacterial extracts? , 2003, Nature Medicine.
[119] Thomas A. Davis,et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[120] F. Haluska,et al. PTEN signaling pathways in melanoma , 2003, Oncogene.
[121] Donna Niedzwiecki,et al. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. , 2003, Cancer research.
[122] Thierry Boon,et al. Tumor‐specific shared antigenic peptides recognized by human T cells , 2002, Immunological reviews.
[123] Yoshimasa Tanaka,et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[124] P. Coulie,et al. Cytolytic T-cell responses of cancer patients vaccinated with a MAGE antigen. , 2002, Immunological reviews.
[125] B. Kwon,et al. New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells. , 2002, Trends in immunology.
[126] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[127] Sridhar Ramaswamy,et al. Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability , 2002, Cell.
[128] Z. Lee,et al. Immune Responses in 4-1BB (CD137)-Deficient Mice1 , 2002, The Journal of Immunology.
[129] G. Schuler,et al. Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells , 2002, The Journal of experimental medicine.
[130] R. Bright. Peptide-Based Cancer Vaccines , 2002, Leukemia.
[131] M. Smyth,et al. NKT cells - conductors of tumor immunity? , 2002, Current opinion in immunology.
[132] L. Akslen,et al. Importance of vascular phenotype by basic fibroblast growth factor, and influence of the angiogenic factors basic fibroblast growth factor/fibroblast growth factor receptor-1 and ephrin-A1/EphA2 on melanoma progression. , 2002, The American journal of pathology.
[133] R. Steinman,et al. Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. , 2001, Cancer research.
[134] R. Offringa,et al. Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine , 2001, The Journal of experimental medicine.
[135] Mark M. Davis,et al. Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[136] S. Ugurel,et al. Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[137] Nina Bhardwaj,et al. Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells , 2001, The Journal of experimental medicine.
[138] J. Utikal,et al. Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastases , 2001, British Journal of Cancer.
[139] G. Freeman,et al. Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation , 2000, The Journal of experimental medicine.
[140] E. Rofstad,et al. Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. , 2000, Cancer research.
[141] M. Mihm,et al. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. , 2000, Cancer research.
[142] E. Price,et al. c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. , 2000, Genes & development.
[143] D. Schadendorf,et al. Expression of interleukin‐8 detected by in situ hybridization correlates with worse prognosis in primary cutaneous melanoma , 1999, The Journal of pathology.
[144] J. Shimizu,et al. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. , 1999, Journal of immunology.
[145] Craig W. Reynolds,et al. Complete molecular remissions induced by patient-specific vaccination plus granulocyte–monocyte colony-stimulating factor against lymphoma , 1999, Nature Medicine.
[146] C. Lowenstein,et al. The Central Role of CD4+ T Cells in the Antitumor Immune Response , 1998, The Journal of experimental medicine.
[147] D. Neuberg,et al. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[148] F. Hodi,et al. Genetically modified tumor cell vaccines. , 1998, Surgical oncology clinics of North America.
[149] F. Marincola,et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma , 1998, Nature Medicine.
[150] D. Pinkel,et al. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. , 1998, Cancer research.
[151] T. Sullivan,et al. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. , 1997, Immunity.
[152] P. Guldberg,et al. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. , 1997, Cancer research.
[153] K. Rock,et al. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. , 1997, Journal of immunology.
[154] H. Antoniades,et al. Expression of platelet‐derived growth factor (PDGF)‐A, PDGF‐B and the PDGF‐alpha receptor, but not the PDGF‐beta receptor, in human malignant melanoma in vivo , 1996, The British journal of dermatology.
[155] A. Carè,et al. HOXB7 constitutively activates basic fibroblast growth factor in melanomas , 1996, Molecular and cellular biology.
[156] J. Allison,et al. Enhancement of Antitumor Immunity by CTLA-4 Blockade , 1996, Science.
[157] D. Becker,et al. Differential expression of the cyclin-dependent kinase inhibitors p16 and p21 in the human melanocytic system. , 1996, Oncogene.
[158] E. Appella,et al. A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes , 1996, The Journal of experimental medicine.
[159] K. Inaba,et al. Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity , 1996, The Journal of experimental medicine.
[160] B. J. Van den Eynde,et al. New tumor antigens recognized by T cells. , 1995, Current opinion in immunology.
[161] M. Serrano,et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma , 1995, Science.
[162] O. de Backer,et al. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma , 1995, The Journal of experimental medicine.
[163] H. Niitani,et al. [Phase II study]. , 1995, Gan to kagaku ryoho. Cancer & chemotherapy.
[164] K. Sakaguchi,et al. Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[165] K. Sakaguchi,et al. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes , 1994, The Journal of experimental medicine.
[166] J. Renauld,et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas , 1994, The Journal of experimental medicine.
[167] A. Albino,et al. Expression of transforming growth factor-beta 2 in malignant melanoma correlates with the depth of tumor invasion. Implications for tumor progression. , 1994, The American journal of pathology.
[168] E. Jaffee,et al. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. , 1994, Science.
[169] S. Rosenberg,et al. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[170] M. Skolnick,et al. A cell cycle regulator potentially involved in genesis of many tumor types. , 1994, Science.
[171] P. Coulie,et al. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas , 1993, The Journal of experimental medicine.
[172] E. Jaffee,et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[173] A. Mackensen,et al. Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. Evidence for in situ T cell clonal expansion. , 1993, The Journal of clinical investigation.
[174] C. Heldin,et al. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[175] P. Chomez,et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. , 1991, Science.
[176] A. Halpern,et al. Model predicting survival in stage I melanoma based on tumor progression. , 1989, Journal of the National Cancer Institute.
[177] R. Fauchet,et al. Presence on a human melanoma of multiple antigens recognized by autologous CTL , 1989, International journal of cancer.
[178] A. Pellicer,et al. Oncogene activation in human benign tumors of the skin (keratoacanthomas): is HRAS involved in differentiation as well as proliferation? , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[179] L. J. Veer,et al. N-ras mutations in human cutaneous melanoma from sun-exposed body sites , 1989, Molecular and cellular biology.
[180] W. E. Fahl,et al. Characterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: sequence analysis of an enzymatically amplified mutant HRAS allele. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[181] G. Currie,et al. A novel transforming gene in a human malignant melanoma cell line , 1984, Nature.
[182] E. Reddy,et al. Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[183] [Recent findings in ]. , 2013, Versicherungsmedizin.
[184] A. McCullough. RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors , 2013 .
[185] G. Barsh,et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi , 2010 .
[186] K. Flaherty,et al. An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. , 2007, Cancer research.
[187] C. Warneke,et al. Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. , 2006, The Journal of investigative dermatology.
[188] T. Watts,et al. TNF/TNFR family members in costimulation of T cell responses. , 2005, Annual review of immunology.
[189] V. Cerundolo,et al. Dendritic cells: a journey from laboratory to clinic , 2004, Nature Immunology.
[190] J. Doroshow,et al. CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. , 2004, Cancer.
[191] C. June,et al. A translational bridge to cancer immunotherapy , 2003, Immunologic research.
[192] F. Kabbinavar,et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[193] D. Schadendorf,et al. Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[194] P. Srivastava,et al. Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation. , 1993, Advances in cancer research.