Language in the cerebellum.

PURPOSE To explore increasingly compelling evidence that the adult human cerebellum is involved in nonmotor affective and cognitive activity, including language-functions that have in the past been associated largely with the limbic system and the cerebral cortex. METHOD We review clinical studies of patients with cerebellar lesions, nonclinical neuroimaging studies of individuals engaged in completing selected tasks, and neuroanatomical as well as neuroimaging studies of brain interconnections. In the course of this review, we also report on a variety of hypotheses regarding the nature of the cerebellum's work in affective processing and language/cognition. RESULTS This review suggests that the cerebellum has considerable influence in language processing and other related higher level affective/cognitive activities. CONCLUSION We conclude with a preliminary list of important clinical implications of these results.

[1]  Markus Frings,et al.  Cerebellar involvement in verb generation: An fMRI study , 2006, Neuroscience Letters.

[2]  A. Aronson,et al.  Motor Speech Disorders , 2014 .

[3]  M. Molinari,et al.  Verbal short-term store-rehearsal system and the cerebellum. Evidence from a patient with a right cerebellar lesion. , 1998, Brain : a journal of neurology.

[4]  E. Courchesne,et al.  Attentional Activation of the Cerebellum Independent of Motor Involvement , 1997, Science.

[5]  A. Jansen,et al.  Crossed cerebro–cerebellar language dominance , 2005, Human brain mapping.

[6]  Y. Joanette,et al.  The Unnoticed Contributions of the Cerebellum to Language , 2007, Folia Phoniatrica et Logopaedica.

[7]  D. Haines,et al.  Clinical symptoms of cerebellar disease and their interpretation , 2008, The Cerebellum.

[8]  Fenna M. Krienen,et al.  Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity , 2009, Cerebral cortex.

[9]  B. Murdoch,et al.  Language Disorders Subsequent to Left Cerebellar Lesions: A Case for Bilateral Cerebellar Involvement in Language? , 2007, Folia Phoniatrica et Logopaedica.

[10]  S. Petersen,et al.  Practice-related changes in human brain functional anatomy during nonmotor learning. , 1994, Cerebral cortex.

[11]  P. Deyn,et al.  The Lateralized Linguistic Cerebellum: A Review and a New Hypothesis , 2001, Brain and Language.

[12]  M. Botez,et al.  Neuropsychological Functioning in Unilateral Cerebellar Damage , 1994, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[13]  A. L. Leiner,et al.  Does the cerebellum contribute to mental skills? , 1986, Behavioral neuroscience.

[14]  J. Desmond,et al.  The contributions of cerebro-cerebellar circuitry to executive verbal working memory , 2010, Cortex.

[15]  Jeremy D. Schmahmann,et al.  Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies , 2009, NeuroImage.

[16]  Rita Moretti,et al.  Language impairments in patients with cerebellar lesions , 2000, Journal of Neurolinguistics.

[17]  J. Bower,et al.  Involvement of the cerebellum in semantic discrimination: An fMRI study , 2003, Human brain mapping.

[18]  M. Posner,et al.  Positron Emission Tomographic Studies of the Processing of Singe Words , 1989, Journal of Cognitive Neuroscience.

[19]  Hubertus Maximilian Mehdorn,et al.  Does the cerebellum contribute to specific aspects of attention? , 2003, Neuropsychologia.

[20]  Bruce E. Murdoch,et al.  The cerebellum and language: Historical perspective and review , 2010, Cortex.

[21]  Julie A. Fiez,et al.  Functional activation in the cerebellum during working memory and simple speech tasks , 2010, Cortex.

[22]  P. Strick,et al.  Cerebellar Loops with Motor Cortex and Prefrontal Cortex of a Nonhuman Primate , 2003, The Journal of Neuroscience.

[23]  E. Moens,et al.  Cerebellar induced aphasia: case report of cerebellar induced prefrontal aphasic language phenomena supported by SPECT findings , 1996, Journal of the Neurological Sciences.

[24]  J. Schmahmann,et al.  The neuropsychiatry of the cerebellum — insights from the clinic , 2008, The Cerebellum.

[25]  Jeremy D. Schmahmann,et al.  The cerebellum and language: Evidence from patients with cerebellar degeneration , 2009, Brain and Language.

[26]  R. Borgatti,et al.  Evidence for a link among cognition, language and emotion in cerebellar malformations , 2010, Cortex.

[27]  Martin I Sereno,et al.  Brain mapping in animals and humans , 1998, Current Opinion in Neurobiology.

[28]  Leslie G. Ungerleider,et al.  Discrete Cortical Regions Associated with Knowledge of Color and Knowledge of Action , 1995, Science.

[29]  Boris Suchan,et al.  Cortico-subcortical contributions to executive control. , 2004, Acta psychologica.

[30]  Jeremy D. Schmahmann,et al.  Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems , 2008, Cortex.

[31]  Peter Mariën,et al.  Cerebellar neurocognition: Insights into the bottom of the brain , 2008, Clinical Neurology and Neurosurgery.

[32]  M. Fox,et al.  Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging , 2007, Nature Reviews Neuroscience.

[33]  J. Schmahmann,et al.  The cerebellar cognitive affective syndrome. , 1998, Brain : a journal of neurology.

[34]  I. Aiello,et al.  Pure post–stroke cerebellar cognitive affective syndrome: a case report , 2004, Neurological Sciences.

[35]  M. Raichle,et al.  Searching for a baseline: Functional imaging and the resting human brain , 2001, Nature Reviews Neuroscience.

[36]  Helen J. Chenery,et al.  Persistent Deficits in Complex Language Function Following Dominant Nonthalamic Subcortical Lesions , 2000 .

[37]  T Hehr,et al.  Oral diadochokinesis in neurological dysarthrias. , 1995, Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics.

[38]  A. Luxen,et al.  Involvement of both prefrontal and inferior parietal cortex in dual-task performance. , 2005, Brain research. Cognitive brain research.

[39]  N. Lassen,et al.  Reduced contralateral hemispheric flow measured by SPECT in cerebellar lesions: crossed cerebral diaschisis. , 1993, Acta neurologica Scandinavica.

[40]  R. Buckner,et al.  Self-projection and the brain , 2007, Trends in Cognitive Sciences.

[41]  D. Schacter,et al.  The Brain's Default Network , 2008, Annals of the New York Academy of Sciences.

[42]  M. Molinari,et al.  Phonological grouping is specifically affected in cerebellar patients: a verbal fluency study , 2000, Journal of neurology, neurosurgery, and psychiatry.

[43]  J. Schmahmann.  Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. , 2004, The Journal of neuropsychiatry and clinical neurosciences.

[44]  M. Molinari,et al.  The cerebellum contributes to linguistic production , 1994, Neurology.

[45]  Bruce E. Murdoch,et al.  Higher‐level language deficits resulting from left primary cerebellar lesions , 2004 .

[46]  D. Braus,et al.  Lateralized organization of the cerebellum in a silent verbal fluency task: a functional magnetic resonance imaging study in healthy volunteers , 2002, Neuroscience Letters.

[47]  M. Wilke,et al.  Reorganization of the cerebro-cerebellar network of language production in patients with congenital left-hemispheric brain lesions , 2008, Brain and Language.

[48]  R. Luerding,et al.  Impaired working-memory after cerebellar infarcts paralleled by changes in BOLD signal of a cortico-cerebellar circuit , 2007, Neuropsychologia.

[49]  D. Sparks,et al.  Neural tract tracing using Di-I: a review and a new method to make fast Di-I faster in human brain , 2000, Journal of Neuroscience Methods.

[50]  A. Nobre,et al.  The Cerebellum Predicts the Timing of Perceptual Events , 2008, The Journal of Neuroscience.

[51]  Peter Mariën,et al.  The Cerebellum and Language: The Story So Far , 2007, Folia Phoniatrica et Logopaedica.

[52]  Peter Mariën,et al.  Cognitive and affective disturbances following focal cerebellar damage in adults: A neuropsychological and SPECT study , 2010, Cortex.

[53]  J. Desmond,et al.  Neuroimaging studies of the cerebellum: language, learning and memory , 1998, Trends in Cognitive Sciences.

[54]  M. Silveri,et al.  Language, memory, and the cerebellum , 2000, Journal of Neurolinguistics.

[55]  H. Rusinek,et al.  Functional magnetic resonance imaging of human brain activity in a verbal fluency task , 1998, Journal of neurology, neurosurgery, and psychiatry.

[56]  R. Schiffer,et al.  Exaggerated crying and tremor with a cerebellar cyst. , 2007, The Journal of neuropsychiatry and clinical neurosciences.

[57]  P. Mariën,et al.  Language, cognition and the cerebellum: Grappling with an enigma , 2010, Cortex.

[58]  S. Petersen,et al.  Impaired non-motor learning and error detection associated with cerebellar damage. A single case study. , 1992, Brain : a journal of neurology.

[59]  P. T. Fox,et al.  Positron emission tomographic studies of the cortical anatomy of single-word processing , 1988, Nature.

[60]  Richard S. J. Frackowiak,et al.  The neural correlates of the verbal component of working memory , 1993, Nature.

[61]  B. Levine,et al.  The functional neuroanatomy of autobiographical memory: A meta-analysis , 2006, Neuropsychologia.

[62]  Olga Ciccarelli,et al.  Linguistic impairment after right cerebellar stroke: a case report , 1999, European journal of neurology.

[63]  R. Nathan Spreng,et al.  The Common Neural Basis of Autobiographical Memory, Prospection, Navigation, Theory of Mind, and the Default Mode: A Quantitative Meta-analysis , 2009, Journal of Cognitive Neuroscience.

[64]  P. Deyn,et al.  Cognitive, linguistic and affective disturbances following a right superior cerebellar artery infarction: A case study , 2009, Cortex.

[65]  Four cases of Friedreich's ataxia: with a critical review of recent literature on the subject , 1898 .

[66]  P. Strick,et al.  Cerebellar Projections to the Prefrontal Cortex of the Primate , 2001, The Journal of Neuroscience.

[67]  S. Paradiso,et al.  The cerebellum and emotional experience , 2007, Neuropsychologia.

[68]  Julie A Fiez,et al.  Cerebellar damage produces selective deficits in verbal working memory. , 2006, Brain : a journal of neurology.

[69]  B. Pakkenberg,et al.  A quantitative study of the human cerebellum with unbiased stereological techniques , 1992, The Journal of comparative neurology.

[70]  P. Strick,et al.  Supplementary Motor Area and Presupplementary Motor Area: Targets of Basal Ganglia and Cerebellar Output , 2007, The Journal of Neuroscience.

[71]  Catherine J. Stoodley,et al.  Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing , 2010, Cortex.

[72]  Stefano F. Cappa,et al.  Agrammatic speech production after a right cerebellar haemorrhage , 1997 .

[73]  P. Deyn,et al.  Neurobehavioral alterations in an adolescent following posterior fossa tumor resection , 2008, The Cerebellum.

[74]  A. L. Leiner,et al.  Reappraising the cerebellum: what does the hindbrain contribute to the forebrain? , 1989, Behavioral neuroscience.

[75]  Timothy Justus.  The Cerebellum and English Grammatical Morphology: Evidence from Production, Comprehension, and Grammaticality Judgments , 2004, Journal of Cognitive Neuroscience.

[76]  C. De Simone,et al.  Cerebellar tumour presenting with pathological laughter and gelastic syncope , 2007, European journal of neurology.

[77]  R. J. Frank,et al.  Reliability of PET activation across statistical methods, subject groups, and sample sizes , 1996, Human brain mapping.