Oncogenic B-Raf(V600E) abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells.

[1]  Philippe P Roux,et al.  RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth , 2013, Oncogene.

[2]  H. Cui,et al.  Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma , 2013, Oncogene.

[3]  C. Blank,et al.  Targeting BRAFV600E in an inducible murine model of melanoma. , 2012, American Journal of Pathology.

[4]  T. Graeber,et al.  BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy. , 2012, Cancer research.

[5]  B. Higgins,et al.  BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines , 2012, PloS one.

[6]  A. Hauschild,et al.  Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial , 2012, The Lancet.

[7]  K. Margolin BRAF inhibition and beyond in advanced melanoma , 2012, The Lancet.

[8]  C. Lehner,et al.  Spindle checkpoint–independent inhibition of mitotic chromosome segregation by Drosophila Mps1 , 2012, Molecular biology of the cell.

[9]  Yuya Yamagishi,et al.  MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components , 2012, Nature Cell Biology.

[10]  Johannes G. Reiter,et al.  The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers , 2012, Nature.

[11]  Ching-Hui Yang,et al.  Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes , 2010, Molecular biology of the cell.

[12]  Kam Y. J. Zhang,et al.  Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma , 2010, Nature.

[13]  K. Flaherty,et al.  Inhibition of mutated, activated BRAF in metastatic melanoma. , 2010, The New England journal of medicine.

[14]  Xiaolong Cheng,et al.  Degradation of the Human Mitotic Checkpoint Kinase Mps1 Is Cell Cycle-regulated by APC-cCdc20 and APC-cCdh1 Ubiquitin Ligases* , 2010, The Journal of Biological Chemistry.

[15]  KyungMann Kim,et al.  Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF. , 2010, The Journal of investigative dermatology.

[16]  Yongping Cui,et al.  Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells. , 2010, Cancer research.

[17]  R. Medema,et al.  Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells , 2009, Proceedings of the National Academy of Sciences.

[18]  Ching-Hui Yang,et al.  Mps1 as a link between centrosomes and genomic instability , 2009, Environmental and molecular mutagenesis.

[19]  J. Reis-Filho,et al.  Oncogenic Braf induces melanocyte senescence and melanoma in mice. , 2009, Cancer cell.

[20]  L. Chin,et al.  Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. , 2009, Molecular cell.

[21]  Laura M. Heiser,et al.  Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. , 2009, Cancer research.

[22]  S. Thomson,et al.  Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. , 2008, Cancer research.

[23]  Yongping Cui,et al.  Knockdown of B-Raf impairs spindle formation and the mitotic checkpoint in human somatic cells , 2008, Cell cycle.

[24]  T. Guadagno,et al.  B-RafV600E signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells , 2008, Oncogene.

[25]  R. Medema,et al.  Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment , 2008, Cell.

[26]  Rey-Huei Chen,et al.  Mps1 Phosphorylation by MAP Kinase Is Required for Kinetochore Localization of Spindle-Checkpoint Proteins , 2006, Current Biology.

[27]  J. Kyriakis,et al.  MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation , 2004, Nature Cell Biology.

[28]  D. Barford,et al.  Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.

[29]  M. Winey,et al.  Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[30]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[31]  Lionel Arnaud,et al.  Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication , 2002, The EMBO journal.

[32]  M. Winey,et al.  The Mouse Mps1p-like Kinase Regulates Centrosome Duplication , 2001, Cell.

[33]  P. Meltzer,et al.  High frequency of BRAF mutations in nevi , 2003, Nature Genetics.

[34]  D. Hogg,et al.  Cell cycle dependent regulation of the protein kinase TTK. , 1994, Oncogene.