Oncogenic B-Raf(V600E) abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells.
暂无分享,去创建一个
Ling Zhang | Caixia Cheng | H. Cui | Bin Song | Yaoping Li | Jing Liu | R. Shi | Y. Bi | Yanyan Zhang | Jinfen Wang | Xiaofeng Yang | Jiansheng Guo | Xing Chen | Xiaolong Cheng | Yongping Cui | Xiaoping Miao | Zhiping Zhao | C. He | Xiaoping Miao
[1] Philippe P Roux,et al. RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth , 2013, Oncogene.
[2] H. Cui,et al. Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma , 2013, Oncogene.
[3] C. Blank,et al. Targeting BRAFV600E in an inducible murine model of melanoma. , 2012, American Journal of Pathology.
[4] T. Graeber,et al. BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy. , 2012, Cancer research.
[5] B. Higgins,et al. BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines , 2012, PloS one.
[6] A. Hauschild,et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial , 2012, The Lancet.
[7] K. Margolin. BRAF inhibition and beyond in advanced melanoma , 2012, The Lancet.
[8] C. Lehner,et al. Spindle checkpoint–independent inhibition of mitotic chromosome segregation by Drosophila Mps1 , 2012, Molecular biology of the cell.
[9] Yuya Yamagishi,et al. MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components , 2012, Nature Cell Biology.
[10] Johannes G. Reiter,et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers , 2012, Nature.
[11] Ching-Hui Yang,et al. Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes , 2010, Molecular biology of the cell.
[12] Kam Y. J. Zhang,et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma , 2010, Nature.
[13] K. Flaherty,et al. Inhibition of mutated, activated BRAF in metastatic melanoma. , 2010, The New England journal of medicine.
[14] Xiaolong Cheng,et al. Degradation of the Human Mitotic Checkpoint Kinase Mps1 Is Cell Cycle-regulated by APC-cCdc20 and APC-cCdh1 Ubiquitin Ligases* , 2010, The Journal of Biological Chemistry.
[15] KyungMann Kim,et al. Induction of autophagy and inhibition of melanoma growth in vitro and in vivo by hyperactivation of oncogenic BRAF. , 2010, The Journal of investigative dermatology.
[16] Yongping Cui,et al. Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells. , 2010, Cancer research.
[17] R. Medema,et al. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells , 2009, Proceedings of the National Academy of Sciences.
[18] Ching-Hui Yang,et al. Mps1 as a link between centrosomes and genomic instability , 2009, Environmental and molecular mutagenesis.
[19] J. Reis-Filho,et al. Oncogenic Braf induces melanocyte senescence and melanoma in mice. , 2009, Cancer cell.
[20] L. Chin,et al. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. , 2009, Molecular cell.
[21] Laura M. Heiser,et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. , 2009, Cancer research.
[22] S. Thomson,et al. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. , 2008, Cancer research.
[23] Yongping Cui,et al. Knockdown of B-Raf impairs spindle formation and the mitotic checkpoint in human somatic cells , 2008, Cell cycle.
[24] T. Guadagno,et al. B-RafV600E signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells , 2008, Oncogene.
[25] R. Medema,et al. Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment , 2008, Cell.
[26] Rey-Huei Chen,et al. Mps1 Phosphorylation by MAP Kinase Is Required for Kinetochore Localization of Spindle-Checkpoint Proteins , 2006, Current Biology.
[27] J. Kyriakis,et al. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation , 2004, Nature Cell Biology.
[28] D. Barford,et al. Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.
[29] M. Winey,et al. Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[30] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[31] Lionel Arnaud,et al. Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication , 2002, The EMBO journal.
[32] M. Winey,et al. The Mouse Mps1p-like Kinase Regulates Centrosome Duplication , 2001, Cell.
[33] P. Meltzer,et al. High frequency of BRAF mutations in nevi , 2003, Nature Genetics.
[34] D. Hogg,et al. Cell cycle dependent regulation of the protein kinase TTK. , 1994, Oncogene.