Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF
暂无分享,去创建一个
[1] Susan S. Taylor,et al. Protein kinases: evolution of dynamic regulatory proteins. , 2011, Trends in biochemical sciences.
[2] M. Baccarini,et al. Targets of Raf in tumorigenesis. , 2010, Carcinogenesis.
[3] Susan S. Taylor,et al. Yet another “active” pseudokinase, Erb3 , 2010, Proceedings of the National Academy of Sciences of the United States of America.
[4] M. Belvin,et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth , 2010, Nature.
[5] Chao Zhang,et al. RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF , 2010, Nature.
[6] J. Reis-Filho,et al. Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF , 2010, Cell.
[7] Robert E. Lewis,et al. KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. , 2009, Cell metabolism.
[8] Marc Therrien,et al. A dimerization-dependent mechanism drives RAF catalytic activation , 2009, Nature.
[9] Deborah K. Morrison,et al. Signaling dynamics of the KSR1 scaffold complex , 2009, Proceedings of the National Academy of Sciences.
[10] Kam Y. J. Zhang,et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity , 2008, Proceedings of the National Academy of Sciences.
[11] N. Dhomen,et al. New insight into BRAF mutations in cancer. , 2007, Current opinion in genetics & development.
[12] D. Barford,et al. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. , 2005, Molecular cell.
[13] R. Kolesnick,et al. Inflammatory bowel disease reveals the kinase activity of KSR1. , 2004, The Journal of clinical investigation.
[14] D. Barford,et al. Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.
[15] Richard Wooster,et al. BRAF and RAS mutations in human lung cancer and melanoma. , 2002, Cancer research.
[16] Kenneth M. Murphy,et al. Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo , 2002, Molecular and Cellular Biology.
[17] D. Morrison,et al. KSR: a MAPK scaffold of the Ras pathway? , 2001, Journal of cell science.
[18] R. Kolesnick,et al. Kinase Suppressor of Ras Signals through Thr269 of c-Raf-1* , 2001, The Journal of Biological Chemistry.
[19] G. Rubin,et al. A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. , 2000, Genetics.
[20] Kun-Liang Guan,et al. Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization , 1999, Molecular and Cellular Biology.
[21] K.,et al. KSR stimulates Raf-1 activity in a kinase-independent manner. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[22] G. Rubin,et al. KSR modulates signal propagation within the MAPK cascade. , 1996, Genes & development.
[23] H. Horvitz,et al. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans , 1995, Cell.
[24] Min Han,et al. The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction , 1995, Cell.
[25] Henry C. Chang,et al. KSR, a novel protein kinase required for RAS signal transduction , 1995, Cell.
[26] D. Knighton,et al. Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. , 1992, The Journal of biological chemistry.
[27] G. Rubin,et al. Signal transduction downstream from Ras in Drosophila. , 1997, Cold Spring Harbor symposia on quantitative biology.