A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory.

[1]  J. Hodgson Gene sequencing's industrial revolution , 2000 .

[2]  Leroy Hood,et al.  Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. , 2004, Journal of proteome research.

[3]  J. Hibbard,et al.  Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers. , 2004, Health services research.

[4]  A. Barabasi,et al.  Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.

[5]  International Human Genome Sequencing Consortium Finishing the euchromatic sequence of the human genome , 2004 .

[6]  Michael E Phelps,et al.  Systems Biology and New Technologies Enable Predictive and Preventative Medicine , 2004, Science.

[7]  George P Patrinos,et al.  DNA, diseases and databases: disastrously deficient. , 2005, Trends in genetics : TIG.

[8]  Y. Lazebnik Can a biologist fix a radio? — or, what I learned while studying apoptosis , 2004, Biochemistry (Moscow).

[9]  L. McGown,et al.  Aptamer stationary phase for protein capture in affinity capillary chromatography. , 2006, Journal of chromatography. A.

[10]  L. Ein-Dor,et al.  Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[11]  John Quackenbush Microarray analysis and tumor classification. , 2006, The New England journal of medicine.

[12]  Amy K. Schmid,et al.  A Predictive Model for Transcriptional Control of Physiology in a Free Living Cell , 2007, Cell.

[13]  N. Christakis,et al.  The Spread of Obesity in a Large Social Network Over 32 Years , 2007, The New England journal of medicine.

[14]  A. Barabasi,et al.  Human disease classification in the postgenomic era: A complex systems approach to human pathobiology , 2007, Molecular systems biology.

[15]  L. Hood,et al.  A personal journey of discovery: developing technology and changing biology. , 2008, Annual review of analytical chemistry.

[16]  John D Aitchison,et al.  Systems biology at the Institute for Systems Biology. , 2008, Briefings in functional genomics & proteomics.

[17]  Nanomedicine targets cancer. , 2009, Scientific American.

[18]  Inyoul Y. Lee,et al.  CHAPTER 6 – Systems Biology and the Emergence of Systems Medicine , 2009 .

[19]  L. Hood,et al.  Systems medicine: the future of medical genomics and healthcare , 2009, Genome Medicine.

[20]  E. Duchoslav,et al.  Rapid screening and characterization of drug metabolites using multiple ion monitoring dependent product ion scan and postacquisition data mining on a hybrid triple quadrupole-linear ion trap mass spectrometer. , 2009, Rapid communications in mass spectrometry : RCM.

[21]  Albert-László Barabási,et al.  A Dynamic Network Approach for the Study of Human Phenotypes , 2009, PLoS Comput. Biol..

[22]  M. Molloy,et al.  Recent progress in selected reaction monitoring MS-driven plasma protein biomarker analysis. , 2009, Bioanalysis.

[23]  Inyoul Y. Lee,et al.  A systems approach to prion disease , 2009, Molecular systems biology.

[24]  I. Janecka Is U.S. health care an appropriate system? A strategic perspective from systems science , 2009, Health research policy and systems.

[25]  Cory C. Funk,et al.  Systems approaches to molecular cancer diagnostics. , 2010, Discovery medicine.

[26]  David M. Simcha,et al.  Tackling the widespread and critical impact of batch effects in high-throughput data , 2010, Nature Reviews Genetics.

[27]  Ariel S. Schwartz,et al.  An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man , 2010, Cell.

[28]  P. Shannon,et al.  Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing , 2010, Science.

[29]  Tom Royce,et al.  A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.

[30]  L. Hood,et al.  Predictive, personalized, preventive, participatory (P4) cancer medicine , 2011, Nature Reviews Clinical Oncology.

[31]  Klaus Pantel,et al.  Cell-free nucleic acids as biomarkers in cancer patients , 2011, Nature Reviews Cancer.

[32]  Catalin C. Barbacioru,et al.  Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients. , 2011, Molecular bioSystems.

[33]  Vibha Rani,et al.  Nanotechnology: Emerging Tool for Diagnostics and Therapeutics , 2011, Applied biochemistry and biotechnology.

[34]  Gustavo D. Parisi,et al.  PCDB: a database of protein conformational diversity , 2010, Nucleic Acids Res..

[35]  Vibhav Garg,et al.  Cloud computing approaches to accelerate drug discovery value chain. , 2011, Combinatorial chemistry & high throughput screening.

[36]  Alexander A. Morgan,et al.  Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data , 2011, Science Translational Medicine.

[37]  A. Mobasheri,et al.  Applications of proteomics in cartilage biology and osteoarthritis research. , 2011, Frontiers in bioscience.

[38]  Rong Fan,et al.  Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells , 2011, Proceedings of the National Academy of Sciences.

[39]  V. de Giorgi,et al.  Circulating cell-free DNA in plasma of melanoma patients: qualitative and quantitative considerations. , 2011, Clinica chimica acta; international journal of clinical chemistry.

[40]  T. Rozek,et al.  Quantitation of total and free teriflunomide (A77 1726) in human plasma by LC-MS/MS. , 2011, Journal of pharmaceutical and biomedical analysis.

[41]  The digital medicine revolution in healthcare. , 2011, Healthcare executive.

[42]  Jung A Kim The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care , 2011 .

[43]  Zuben E. Sauna,et al.  Aptamers as a Sensitive Tool to Detect Subtle Modifications in Therapeutic Proteins , 2012, PloS one.

[44]  Gilbert S Omenn,et al.  SRM targeted proteomics in search for biomarkers of HCV‐induced progression of fibrosis to cirrhosis in HALT‐C patients , 2012, Proteomics.

[45]  Jaeyun Sung,et al.  Molecular signatures from omics data: From chaos to consensus , 2012, Biotechnology journal.

[46]  T. Hudson,et al.  The Genetic Basis for Cancer Treatment Decisions , 2012, Cell.

[47]  L. Hood,et al.  Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine , 2012, Journal of internal medicine.

[48]  T. Kevin Hitchens,et al.  Tracking T-cells in vivo with a new nano-sized MRI contrast agent. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[49]  S. Matsusaka,et al.  Circulating tumor cells as a surrogate marker for determining response to chemotherapy in Japanese patients with metastatic colorectal cancer. , 2012, Journal of Clinical Oncology.

[50]  J. Eberwine,et al.  Drug targets: single-cell transcriptomics hastens unbiased discovery. , 2012, Trends in pharmacological sciences.

[51]  Hugo Y. K. Lam,et al.  Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes , 2012, Cell.

[52]  Sebastiano Collino,et al.  Clinical metabolomics paves the way towards future healthcare strategies. , 2013, British journal of clinical pharmacology.