Central and peripheral autonomic influences : analysis of cardio-pulmonary dynamics using novel wavelet statistical methods

CENTRAL AND PERIPHERAL AUTONOMIC INFLUENCES: ANALYSIS OF CARDIOPULMONARY DYNAMICS USING NOVEL WAVELET STATISTICAL METHODS by Anne Marie Petrock The development and implementation of novel signal processing techniques, particularly with regard to applications in the clinical environment, is critical to bringing computeraided diagnoses of disease to reality. One of the most confounding factors in the field of cardiac autonomic response (CAR) research is the influence of the coupling of respiratory oscillations with cardiac oscillations. This research had three objectives. The first was the assessment of central autonomic influence over heart rate oscillations when the pulmonary system is damaged. The second was to assess the link between peripheral and central autonomic control schema by evaluating the heart rate variability (HRV) of people who were able or unable to adapt to the use of integrated lenses for vision, specifically accommodation, correction (adaptive and non-adaptive presbyopes). The third objective was the development of a wavelet-based toolset by which the first two objectives could be achieved. The first tool is a wavelet based entropy measure that quantifies the level of information by assessing not only the entropy levels, but also the distribution of the entropy across frequency bands. The second tool is a wavelet source separation (WavS) method used to separate the respiratory component from the cardiac component, thereby allowing for analysis of the dynamics of the cardiac signal without the confounding influence of the respiratory signal that occurs when the body is perturbed. With regard to hypothesis one, the entropy method was used to separate the COPD study populations with 93% classification accuracy at rest, and with 100% accuracy during exercise. Changes in COPD and control autonomic markers were evident after respiration is removed. Specifically, the LF/HF ratio slightly decreased on average from pre to post reconstruction for controls, increased on average for COPD. In healthy controls, respiration frequency is distributed across multiple bandwidths, causing large decreases in both LF and HF when removed. With respiration effect removed from COPD population, LF dominates autonomic response, indicating that the frequency is concentrated in the HF autonomic region. Decrease in variance of data set increases probability that smaller changes can be detected in values. The theory set forth in hypothesis two was validated by the quantification of a correlation between peripheral and central autonomic influences, as evidenced by differences in oculomotor adaptability correlating with differences in HRV. Standard Deviation varies with grouping, not with age. Increasing controlled respiration frequencies resulted in adaptive presbyopes and controls displaying similar sympathetic responses, diverging from non-adaptive group. WayS reduced frequency content in ranges concurrent with breathing rate, indicating a robust analysis. The outcome of hypothesis three was the confirmation that wavelet statistical methods possess significant potential for applications in HRV. Entropy can be used in conjunction with cluster analysis to classify patient populations with high accuracy. Using the WayS analysis, the respiration effect can be removed from HRV data sets, providing new insights into autonomic alterations, both central and peripheral, in disease, CENTRAL AND PERIPHERAL AUTONOMIC INFLUENCES: ANALYSIS OF CARDlO-PULMONARY DYNAMICS USING NOVEL WAVELET STATISTICAL METHODS by Anne Marie Petrock A Dissertation Submitted to the Faculty of New Jersey Institute of Technology in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Biomedical Engineering Department of Biomedical Engineering

[1]  Osvaldo A. Rosso,et al.  Wavelet statistical complexity analysis of the classical limit , 2003 .

[2]  D. Newandee Time-frequency investigation of heart rate variability and cardiovascular system modeling of normal and chronic obstructive pulmonary disease (COPD) subjects , 2003 .

[3]  Paul S Addison,et al.  Wavelet transforms and the ECG: a review , 2005, Physiological measurement.

[4]  Osvaldo A. Rosso,et al.  Brain electrical activity analysis using wavelet-based informational tools (II): Tsallis non-extensivity and complexity measures , 2003 .

[5]  Neural regulation of cardiovascular function explored in the frequency domain , 2001, Autonomic Neuroscience.

[6]  Kwang Suk Park,et al.  Characterizing EEG during mental activity using non-linear measures: the more concentration, the higher correlation dimension , 2000, Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Cat. No.00CH37143).

[7]  Madalena Costa,et al.  Multiscale entropy analysis of complex physiologic time series. , 2002, Physical review letters.

[8]  Georgios B. Giannakis,et al.  On regularity and identifiability of blind source separation under constant-modulus constraints , 2004, 2004 IEEE International Conference on Acoustics, Speech, and Signal Processing.

[9]  Aapo Hyvärinen,et al.  Survey on Independent Component Analysis , 1999 .

[10]  Shyh-Jier Huang,et al.  Coiflet wavelet transform applied to inspect power system disturbance-generated signals , 2002 .

[11]  M Akay,et al.  Fractal Analyses of HRV Signals: A Comparative Study , 1997, Methods of Information in Medicine.

[12]  J. S. Sahambi,et al.  Using Wavelet Transforms for ECG Characterization , 1997 .

[13]  Haruyuki Minamitani,et al.  Assessment of autonomic function and mental condition on cardio-respiratory variability and thermal regulation by using neural network , 1998, Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286).

[14]  P. Dolan,et al.  Fatigue of the Erector Spinae Muscles: A Quantitative Assessment Using “Frequency Banding” of the Surface Electromyography Signal , 1995, Spine.

[15]  Solange Akselrod,et al.  Estimation of autonomic response based on individually determined time axis , 2001, Autonomic Neuroscience.

[16]  Geoffrey Ye Li,et al.  Adaptive Blind Source Separation and Equalization for Multiple-Input/Multiple-Output Systems , 1998, IEEE Trans. Inf. Theory.

[17]  A. Malliani,et al.  Sympathetic rhythms and cardiovascular oscillations , 2001, Autonomic Neuroscience.

[18]  Jean-Marc Le Caillec,et al.  Nonlinear system identification using autoregressive quadratic models , 2001, Signal Process..

[19]  Ronitt Rubinfeld,et al.  The complexity of approximating the entropy , 2002, Proceedings 17th IEEE Annual Conference on Computational Complexity.

[20]  Dirk Hoyer,et al.  Mutual information and phase dependencies: measures of reduced nonlinear cardiorespiratory interactions after myocardial infarction. , 2002, Medical engineering & physics.

[21]  Ruey-Wen Liu,et al.  General approach to blind source separation , 1996, IEEE Trans. Signal Process..

[22]  Density deconvolution based on wavelets with bounded supports , 2002 .

[23]  M. Bartels,et al.  High-frequency modulation of heart rate variability during exercise in patients with COPD. , 2003, Chest.

[24]  M. Tachibana,et al.  Investigation of the influence of swallowing, coughing and vocalization on heart rate variability with respiratory-phase domain analysis. , 2007, Methods of information in medicine.

[25]  Luca T. Mainardi,et al.  Extraction of the respiration influence from the heart rate variability signal by means of lattice adaptive filter , 1994, Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[26]  Osvaldo A. Rosso,et al.  Wavelet analysis of generalized tonic-clonic epileptic seizures , 2003, Signal Process..

[27]  Complexity analysis of heart rate variability applied to chagasic patients and normal subjects , 2000, Computers in Cardiology 2000. Vol.27 (Cat. 00CH37163).

[28]  M. Akay,et al.  Short-term analysis of heart-rate variability of adapted wavelet transforms , 1997, IEEE Engineering in Medicine and Biology Magazine.

[29]  Jean-Francois Cardoso,et al.  Blind signal separation: statistical principles , 1998, Proc. IEEE.

[30]  C. Valens,et al.  A Really Friendly Guide to Wavelets , 1999 .

[31]  Jean-Franois Cardoso High-Order Contrasts for Independent Component Analysis , 1999, Neural Computation.

[32]  E. Basar,et al.  Wavelet entropy: a new tool for analysis of short duration brain electrical signals , 2001, Journal of Neuroscience Methods.

[33]  M. Bartels,et al.  Oxygen supplementation and cardiac-autonomic modulation in COPD. , 2000, Chest.

[34]  S. Min,et al.  Power spectral analysis of heart rate variability during acute hypoxia in fetal lambs , 2002, Acta obstetricia et gynecologica Scandinavica.

[35]  Solange Akselrod,et al.  Parametric description of cardiac vagal control , 2003, Autonomic Neuroscience.

[36]  Jun Liang,et al.  A method of process monitoring based on blind source separation with denoising information by wavelet transform and its application to chemical process , 2004, 2004 IEEE International Conference on Systems, Man and Cybernetics (IEEE Cat. No.04CH37583).

[37]  Autonomic function evaluated by entropy measures of the heart rate variability , 2000, Computers in Cardiology 2000. Vol.27 (Cat. 00CH37163).

[38]  Ahmet Arslan,et al.  A wavelet neural network for the detection of heart valve diseases , 2003, Expert Syst. J. Knowl. Eng..

[39]  Pierre Comon,et al.  Independent component analysis, A new concept? , 1994, Signal Process..

[40]  Adaptive cancellation of respiratory sinus arrhythmia , 1990, [1990] Proceedings Computers in Cardiology.

[41]  P. Larsen,et al.  Cardioventilatory Coupling in Resting Human Subjects , 2003, Experimental physiology.

[42]  E. Basar,et al.  Wavelet entropy analysis of event-related potentials indicates modality-independent theta dominance , 2002, Journal of Neuroscience Methods.

[43]  S. Mallat A wavelet tour of signal processing , 1998 .

[44]  Madalena Costa,et al.  Multiscale entropy analysis of biological signals. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[45]  G. Carrault,et al.  Comparing wavelet transforms for recognizing cardiac patterns , 1995 .

[46]  J. Kurths,et al.  Quantitative analysis of heart rate variability. , 1995, Chaos.

[47]  Daniel Lemire,et al.  Wavelet time entropy, T wave morphology and myocardial ischemia , 2000, IEEE Transactions on Biomedical Engineering.

[48]  P. Caminal,et al.  Non-linear dynamics in heart rate variability of normal subjects and chagasic patients , 2000, Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Cat. No.00CH37143).

[50]  H. Stanley,et al.  Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. , 1995, Chaos.

[51]  Terrence L. Fine,et al.  Testing for stochastic independence: application to blind source separation , 2005, IEEE Transactions on Signal Processing.

[52]  Julián J. González,et al.  Detection and sources of nonlinearity in the variability of cardiac R-R intervals and blood pressure in rats. , 2000, American journal of physiology. Heart and circulatory physiology.

[53]  Ivanov PCh,et al.  Application of statistical physics to heartbeat diagnosis. , 1999, Physica A.

[54]  J. Kurths,et al.  The application of methods of non-linear dynamics for the improved and predictive recognition of patients threatened by sudden cardiac death. , 1996, Cardiovascular research.

[55]  G. Zouridakis,et al.  Comparison between ICA and wavelet-based denoising of single-trial evoked potentials , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[56]  Alexander M. Bronstein,et al.  Quasi maximum likelihood MIMO blind deconvolution: Super- and sub-Gaussianity versus consistency , 2005, IEEE Transactions on Signal Processing.

[57]  Pei-wen Que,et al.  Wavelet based noise suppression technique and its application to ultrasonic flaw detection. , 2006, Ultrasonics.

[58]  Solange Akselrod,et al.  Wavelet analysis of instantaneous heart rate: a study of autonomic control during thrombolysis. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[59]  Lawrence E Mays,et al.  Neuronal circuitry controlling the near response , 1995, Current Opinion in Neurobiology.

[60]  Christian Blatter Wavelets: A Primer , 1999 .

[61]  S. Cerutti,et al.  Continuous quantification of respiratory and baroreflex control of heart rate: use of time-variant bivariate spectral analysis , 1994, Computers in Cardiology 1994.

[62]  Y. Z. Ider,et al.  Model based and experimental investigation of respiratory effect on the HRV power spectrum , 2006, Physiological measurement.

[63]  Johann Jaeger,et al.  A new approach to high-speed protection for transmission line based on transient signal analysis using wavelets , 2001 .

[64]  M. Jembrek-Gostovic,et al.  Non-linear dynamics in patients with stable angina pectoris , 2001, Computers in Cardiology 2001. Vol.28 (Cat. No.01CH37287).

[65]  Data-dependent filter characteristics of peak-valley respiratory sinus arrhythmia estimation: a cautionary note. , 1993, Psychophysiology.

[67]  Tara L. Alvarez,et al.  Divergence eye movements are dependent on initial stimulus position , 2005, Vision Research.

[68]  L. G. Gamero,et al.  Heart rate variability analysis using wavelet transform , 1996, Computers in Cardiology 1996.

[69]  S Cerutti,et al.  The neural regulation of circulation explored in the frequency domain. , 1990, Journal of the autonomic nervous system.

[70]  A. Petrock,et al.  Total wavelet entropy analysis of cyclic exercise protocol on heart rate variability , 2004, IEEE 30th Annual Northeast Bioengineering Conference, 2004. Proceedings of the.

[71]  Yimin Zhang,et al.  Blind Separation of Nonstationary Sources Based on Spatial Time-Frequency Distributions , 2006, EURASIP J. Adv. Signal Process..

[72]  F Mastropasqua,et al.  Effect of respiratory rate on the relationships between RR interval and systolic blood pressure fluctuations: a frequency-dependent phenomenon. , 1998, Cardiovascular research.

[73]  Solange Akselrod,et al.  Time–frequency analysis of transient signals – application to cardiovascular control , 1998 .

[74]  Er-Wei Bai,et al.  Blind source separation/channel equalization of nonlinear channels with binary inputs , 2005, IEEE Transactions on Signal Processing.

[75]  Xiao-Ping Zhang,et al.  Nonlinear adaptive noise suppression based on wavelet transform , 1998, Proceedings of the 1998 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP '98 (Cat. No.98CH36181).

[76]  Hershel Raff,et al.  Human Physiology: The Mechanisms of Body Function , 2006 .

[77]  P. Saparin,et al.  Renormalised entropy: a new method of non-linear dynamics for the analysis of heart rate variability , 1994, Computers in Cardiology 1994.

[78]  R E De Meersman,et al.  Deriving respiration from pulse wave: a new signal-processing technique. , 1996, The American journal of physiology.