TFEB inhibition induces melanoma shut-down by blocking the cell cycle and rewiring metabolism
暂无分享,去创建一个
F. Costanza | C. Riganti | G. Doronzo | F. Bussolino | D. Corà | E. Astanina | V. Comunanza | E. Casanova | M. Akman | C. Ariano | F. Costanza
[1] A. Ballabio,et al. The TFEB-TGIF1 axis regulates EMT in mouse epicardial cells , 2022, Nature Communications.
[2] C. Riganti,et al. TFEB controls integrin-mediated endothelial cell adhesion by the regulation of cholesterol metabolism , 2022, Angiogenesis.
[3] F. Esmaeili,et al. Dual-specificity phosphatases: therapeutic targets in cancer therapy resistance , 2022, Journal of Cancer Research and Clinical Oncology.
[4] Chunying Li,et al. Signal pathways of melanoma and targeted therapy , 2021, Signal Transduction and Targeted Therapy.
[5] Kisuk Min,et al. Fasting-Induced Upregulation of MKP-1 Modulates the Hepatic Response to Feeding , 2021, Nutrients.
[6] A. Porcelli,et al. Respiratory Complex I dysfunction in cancer: from a maze of cellular adaptive responses to potential therapeutic strategies , 2021, The FEBS journal.
[7] G. Doronzo,et al. The Oncogene Transcription Factor EB Regulates Vascular Functions , 2021, Frontiers in Physiology.
[8] J. Kim,et al. TFEB Supports Pancreatic Cancer Growth through the Transcriptional Regulation of Glutaminase , 2021, Cancers.
[9] G. Doronzo,et al. Multifaceted activities of transcription factor EB in cancer onset and progression , 2020, Molecular oncology.
[10] E. Steingrímsson,et al. MITF and TFEB cross-regulation in melanoma cells , 2020, PloS one.
[11] Tiangang Li,et al. An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis , 2020, Nature Communications.
[12] Jessica K. Gagnon,et al. ERK signalling: a master regulator of cell behaviour, life and fate , 2020, Nature Reviews Molecular Cell Biology.
[13] Li Yang,et al. The regulation of TFEB in lipid homeostasis of non-alcoholic fatty liver disease: Molecular mechanism and promising therapeutic targets. , 2020, Life sciences.
[14] Wancai Yang,et al. EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma , 2020, Oncogene.
[15] B. Razani,et al. TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction , 2019, Science Signaling.
[16] A. Osterman,et al. Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity. , 2019, Molecular cell.
[17] A. Esposito,et al. Interaction of Cholesterol With the Human SLC1A5 (ASCT2): Insights Into Structure/Function Relationships , 2019, Front. Mol. Biosci..
[18] M. R. Ruocco,et al. Metabolic flexibility in melanoma: a potential therapeutic target. , 2019, Seminars in cancer biology.
[19] T. Soga,et al. MITF controls the TCA cycle to modulate the melanoma hypoxia response , 2019, Pigment cell & melanoma research.
[20] L. Fournel,et al. Interconnection between Metabolism and Cell Cycle in Cancer. , 2019, Trends in biochemical sciences.
[21] C. Goding,et al. MITF—the first 25 years , 2019, Genes & development.
[22] Qingsong Liu,et al. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance , 2019, Nature Communications.
[23] Fujun Li,et al. Weighted correlation network and differential expression analyses identify candidate genes associated with BRAF gene in melanoma , 2019, BMC Medical Genetics.
[24] A. Ballabio,et al. MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer. , 2019, Annual review of cancer biology.
[25] S. Keyse,et al. Dual-specificity MAP kinase phosphatases in health and disease☆ , 2019, Biochimica et biophysica acta. Molecular cell research.
[26] Edward T Chouchani,et al. Coupling Krebs cycle metabolites to signalling in immunity and cancer , 2018, Nature Metabolism.
[27] A. Ballabio,et al. TFEB controls vascular development by regulating the proliferation of endothelial cells , 2018, The EMBO journal.
[28] J. Sosman,et al. Melanoma: What do all the mutations mean? , 2018, Cancer.
[29] Maria Matarese,et al. mTOR-dependent phosphorylation controls TFEB nuclear export , 2018, Nature Communications.
[30] C. Gati,et al. Cryo-EM structure of the human neutral amino acid transporter ASCT2 , 2018, Nature Structural & Molecular Biology.
[31] A. Ballabio,et al. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization , 2018, The EMBO journal.
[32] M. Beal,et al. Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. , 2018, Cell metabolism.
[33] M. Minczuk,et al. NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction , 2018, Molecular cell.
[34] K. Komurov,et al. c-Fos and Dusp1 confer non-oncogene addiction in BCR-ABL induced leukemia , 2017, Nature medicine.
[35] D. Fisher,et al. The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology. , 2017, Laboratory investigation; a journal of technical methods and pathology.
[36] R. Bast,et al. Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression , 2017, Autophagy.
[37] A. Ballabio,et al. Transcription Factor EB Controls Metabolic Flexibility during Exercise , 2017, Cell metabolism.
[38] T. Jacks,et al. PKM2, cancer metabolism, and the road ahead , 2016, EMBO reports.
[39] H. Land,et al. Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells , 2016, Cell reports.
[40] M. Bosenberg,et al. The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations , 2016, Pigment cell & melanoma research.
[41] A. Bácsi,et al. RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1. , 2016, Cellular signalling.
[42] B. Bastian,et al. From melanocytes to melanomas , 2016, Nature Reviews Cancer.
[43] Jeffrey W. Smith,et al. Metabolic rewiring in melanoma , 2016, Oncogene.
[44] E. Petricoin,et al. Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest , 2015, Oncotarget.
[45] Sumul Ashok Gandhi,et al. Skin Cancer Epidemiology, Detection, and Management. , 2015, The Medical clinics of North America.
[46] A. Bosserhoff,et al. Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells , 2015, Oncotarget.
[47] K. Coombes,et al. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. , 2015, Cancer cell.
[48] K. Ross,et al. Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism , 2015, Nature.
[49] P. Guldberg,et al. Molecular drivers of cellular metabolic reprogramming in melanoma. , 2015, Trends in molecular medicine.
[50] J. Villena. New insights into PGC‐1 coactivators: redefining their role in the regulation of mitochondrial function and beyond , 2015, The FEBS journal.
[51] M. Malumbres. Cyclin-dependent kinases , 2014, Genome Biology.
[52] J. Fisher,et al. Multiple murine BRafV600E melanoma cell lines with sensitivity to PLX4032 , 2014, Pigment cell & melanoma research.
[53] J. Bujnicki,et al. Statins impair glucose uptake in human cells , 2014, BMJ Open Diabetes Research and Care.
[54] J. Martina,et al. Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis , 2014, Cellular and Molecular Life Sciences.
[55] Jie Li,et al. PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells , 2013, Cell.
[56] Andrea Ballabio,et al. Signals from the lysosome: a control centre for cellular clearance and energy metabolism , 2013, Nature Reviews Molecular Cell Biology.
[57] J. Bartek,et al. Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene , 2013, Oncotarget.
[58] Jun S. Song,et al. Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. , 2013, Cancer cell.
[59] A. L. La Spada. PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease , 2012, Autophagy.
[60] Boris Ratnikov,et al. Glutamine‐fueled mitochondrial metabolism is decoupled from glycolysis in melanoma , 2012, Pigment cell & melanoma research.
[61] L. Alberghina,et al. Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling , 2012, Front. Physio..
[62] T. Walther,et al. The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis , 2012, Science Signaling.
[63] J. Bujnicki,et al. Statins impair glucose uptake in tumor cells. , 2012, Neoplasia.
[64] W. Marston Linehan,et al. Reductive carboxylation supports growth in tumor cells with defective mitochondria , 2011, Nature.
[65] B. Sharma. Kinetic Characterisation of Phosphofructokinase Purified from Setaria cervi: A Bovine Filarial Parasite , 2011, Enzyme research.
[66] Andrea Ballabio,et al. TFEB Links Autophagy to Lysosomal Biogenesis , 2011, Science.
[67] Angela Re,et al. CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse , 2010, BMC Bioinformatics.
[68] M. Dembo,et al. Modification of Cellular Cholesterol Content Affects Traction Force, Adhesion and Cell Spreading , 2010, Cellular and molecular bioengineering.
[69] Horng-mo Lee,et al. The investigation of Mitogen-Activated Protein kinase Phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging , 2010, BMC Cancer.
[70] Kelly K. Haagenson,et al. Mitogen activated protein kinase phosphatases and cancer , 2010, Cancer biology & therapy.
[71] R. Deberardinis,et al. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer , 2010, Oncogene.
[72] Hideaki Mitsui,et al. Tumorigenesis and Neoplastic Progression Down-Regulation of DUSP 6 Expression in Lung Cancer Its Mechanism and Potential Role in Carcinogenesis , 2010 .
[73] Yan Fu,et al. MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1. , 2009, The Journal of investigative dermatology.
[74] Eric Chevet,et al. Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer , 2008, Pharmacological Reviews.
[75] Peter Tontonoz,et al. Fat and beyond: the diverse biology of PPARgamma. , 2008, Annual review of biochemistry.
[76] S A Forbes,et al. The Catalogue of Somatic Mutations in Cancer (COSMIC) , 2008, Current protocols in human genetics.
[77] H. Christofk,et al. Pyruvate kinase M2 is a phosphotyrosine-binding protein , 2008, Nature.
[78] Kam Y. J. Zhang,et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity , 2008, Proceedings of the National Academy of Sciences.
[79] R. Deberardinis,et al. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis , 2007, Proceedings of the National Academy of Sciences.
[80] J. Pouysségur,et al. ERK implication in cell cycle regulation. , 2007, Biochimica et biophysica acta.
[81] S. Keyse,et al. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases , 2007, Oncogene.
[82] J. Pouysségur,et al. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition , 2007, Oncogene.
[83] N. Copeland,et al. Melanocytes and the microphthalmia transcription factor network. , 2004, Annual review of genetics.
[84] J. Arbiser. Activation of B-raf in non-malignant nevi predicts a novel tumor suppressor gene in melanoma (MAP kinase phosphatase). , 2003, The Journal of investigative dermatology.
[85] L. Ailles,et al. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences , 2000, Nature Genetics.
[86] OUP accepted manuscript , 2021, Nucleic Acids Research.
[87] D. Hood,et al. Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner. , 2018, American journal of physiology. Cell physiology.
[88] B. Staels,et al. PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD , 2017, Nature Reviews Endocrinology.