Prospects of Modulating Protein–Protein Interactions

This chapter provides an overview of the approaches used for the design of chemical modulators of protein–protein interactions using computational methods in combination with experimental assays. Strategies for the identification and design of inhibitors of PPIs are presented, including methodologies, advantages, and limitations of the approaches discussed. Examples of the successful application of computational method to protein–protein inhibitor design are presented for the proteins ERK kinase, BCL6, S100B, and the p56Lck kinase SH2 domain.

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