The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

[1]  A. M. van der Bliek,et al.  A Human Dynamin-related Protein Controls the Distribution of Mitochondria , 1998, The Journal of cell biology.

[2]  D. Wallace.  Mitochondrial diseases in man and mouse. , 1999, Science.

[3]  A. M. van der Bliek,et al.  C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. , 1999, Molecular cell.

[4]  D. Sinclair,et al.  Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1* , 2002, The Journal of Biological Chemistry.

[5]  A. Feinberg,et al.  SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[6]  K. Inoki,et al.  TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.

[7]  G. Magni,et al.  Enzymology of NAD+ homeostasis in man , 2003, Cellular and Molecular Life Sciences CMLS.

[8]  Christopher M. Gallo,et al.  Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity , 2004, Molecular and Cellular Biology.

[9]  D. Stojanovski,et al.  Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology , 2004, Journal of Cell Science.

[10]  K. Mihara,et al.  Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity , 2004, Journal of Cell Science.

[11]  J. Connor,et al.  Iron, brain ageing and neurodegenerative disorders , 2004, Nature Reviews Neuroscience.

[12]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[13]  G. Bjørkøy,et al.  p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy* , 2007, Journal of Biological Chemistry.

[14]  B. Burgering,et al.  The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival , 2007, Mechanisms of Ageing and Development.

[15]  C. Brenner,et al.  Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+ , 2007, Cell.

[16]  M. Mattson,et al.  Mitochondria in Neuroplasticity and Neurological Disorders , 2008, Neuron.

[17]  Nicholas E. Bruns,et al.  A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy , 2008, Proceedings of the National Academy of Sciences.

[18]  C. Brenner,et al.  Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. , 2008, Annual review of nutrition.

[19]  G. Lenaers,et al.  OPA1 functions in mitochondria and dysfunctions in optic nerve. , 2009, The international journal of biochemistry & cell biology.

[20]  Arunima Sengupta,et al.  FoxO Transcription Factors Promote Autophagy in Cardiomyocytes* , 2009, The Journal of Biological Chemistry.

[21]  P. Puigserver,et al.  AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity , 2009, Nature.

[22]  H. T. Kang,et al.  Nicotinamide enhances mitochondria quality through autophagy activation in human cells , 2009, Aging cell.

[23]  P. Belenguer,et al.  The BH3‐only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms , 2010, EMBO reports.

[24]  T. Uzu,et al.  Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. , 2010, The Journal of clinical investigation.

[25]  P.A.C.R. Costa,et al.  A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data , 2010, BMC Genomics.

[26]  G. Mills,et al.  ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS , 2010, Proceedings of the National Academy of Sciences.

[27]  V. Mootha,et al.  The mitochondrial proteome and human disease. , 2010, Annual review of genomics and human genetics.

[28]  R. DePinho,et al.  Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes , 2010, Circulation research.

[29]  W. Martin,et al.  The energetics of genome complexity , 2010, Nature.

[30]  D. Rubinsztein,et al.  Autophagy and Aging , 2011, Cell.

[31]  B. Viollet,et al.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.

[32]  Youngil Lee,et al.  Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. , 2011, American journal of physiology. Heart and circulatory physiology.

[33]  B. Viollet,et al.  Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy , 2011, Science.

[34]  J. Auwerx,et al.  The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. , 2012, Cell metabolism.

[35]  P. Xue,et al.  Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells , 2012, Nature Cell Biology.

[36]  D. Wallace.  Mitochondria and cancer , 2012, Nature Reviews Cancer.

[37]  C. Kraft,et al.  Mechanism and functions of membrane binding by the Atg5–Atg12/Atg16 complex during autophagosome formation , 2012, The EMBO journal.

[38]  S. Archer,et al.  SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress , 2013, Molecular and Cellular Biology.

[39]  E. Chini,et al.  Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors , 2013, Clinical Cancer Research.

[40]  K. Boini,et al.  Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes , 2013, Journal of cellular and molecular medicine.

[41]  E. Mercken,et al.  Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging , 2013, Cell.

[42]  Simon C Watkins,et al.  Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells , 2013, Nature Cell Biology.

[43]  S. Schuster,et al.  Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. , 2013, Nature chemical biology.

[44]  M. Prince,et al.  World Alzheimer Report 2013 , 2014 .

[45]  M. Mattson,et al.  Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession , 2013, Neurobiology of Aging.

[46]  C. Chu,et al.  After the banquet , 2013, Autophagy.

[47]  L. Tsai,et al.  SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons , 2013, Nature Neuroscience.

[48]  G. Pasinetti,et al.  Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models , 2013, Neurobiology of Aging.

[49]  M. Sakaguchi,et al.  SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria , 2013, Molecular biology of the cell.

[50]  J. Toro.  World Alzheimer Report 2013 , 2013 .

[51]  L. Guarente,et al.  The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling , 2013, Cell.

[52]  H. Broxmeyer,et al.  SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress , 2014, Stem cells.

[53]  K. Kuwano,et al.  Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence , 2014, The Journal of Immunology.

[54]  Leyuan Liu,et al.  Autophagy Inhibitor LRPPRC Suppresses Mitophagy through Interaction with Mitophagy Initiator Parkin , 2014, PloS one.

[55]  Lesley Cheng,et al.  Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood , 2014, Journal of extracellular vesicles.

[56]  Philip M. Kim,et al.  A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening , 2014, Genome Medicine.

[57]  S. Imai,et al.  Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging , 2014, The EMBO journal.

[58]  E. Schadt,et al.  Geroscience: Linking Aging to Chronic Disease , 2014, Cell.

[59]  L. Brace,et al.  Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction , 2014, Cell.

[60]  Yossi Kalifa,et al.  Paternal mitochondrial destruction after fertilization is mediated by a common endocytic and autophagic pathway in Drosophila. , 2014, Developmental cell.

[61]  A. Tee,et al.  mTOR and autophagy: a dynamic relationship governed by nutrients and energy. , 2014, Seminars in cell & developmental biology.

[62]  D. Das,et al.  Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN , 2014, Oxidative medicine and cellular longevity.

[63]  Yuanli Liu,et al.  A research agenda for aging in China in the 21st century , 2015, Ageing Research Reviews.

[64]  Jürgen Schmidhuber,et al.  Deep learning in neural networks: An overview , 2014, Neural Networks.

[65]  A. Nikiforov,et al.  The human NAD metabolome: Functions, metabolism and compartmentalization , 2015, Critical reviews in biochemistry and molecular biology.

[66]  M. Russo,et al.  SIRT5 regulation of ammonia-induced autophagy and mitophagy , 2015, Autophagy.

[67]  Z. Qin,et al.  A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation , 2015, Autophagy.

[68]  Aaron Long,et al.  Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model , 2015, BMC Neurology.

[69]  J. Burman,et al.  The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy , 2015, Nature.

[70]  A. Fagan,et al.  Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research , 2015, Alzheimer's & Dementia.

[71]  J. Auwerx,et al.  NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. , 2015, Cell metabolism.

[72]  V. Bohr,et al.  Protecting the mitochondrial powerhouse. , 2015, Trends in cell biology.

[73]  J. Lippincott-Schwartz,et al.  Deacetylation of nuclear LC3 drives autophagy initiation under starvation. , 2015, Molecular cell.

[74]  T. Hartmann,et al.  Alzheimer's disease pathology is attenuated in a CD38‐deficient mouse model , 2015, Annals of neurology.

[75]  Núria Queralt-Rosinach,et al.  Extraction of relations between genes and diseases from text and large-scale data analysis: implications for translational research , 2014, BMC Bioinformatics.

[76]  E. Verdin.  NAD+ in aging, metabolism, and neurodegeneration , 2015, Science.

[77]  Evgeny Putin,et al.  Deep biomarkers of human aging: Application of deep neural networks to biomarker development , 2016, Aging.

[78]  K. Ye,et al.  Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin , 2016, Oncotarget.

[79]  Cícero Nogueira dos Santos,et al.  Boosting Docking-Based Virtual Screening with Deep Learning , 2016, J. Chem. Inf. Model..

[80]  Jun Yu,et al.  Critical Role of Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection , 2016, The Journal of Immunology.

[81]  Jin-A Lee,et al.  Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy , 2016, BMB reports.

[82]  P. Newsholme,et al.  Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis , 2016, Mechanisms of Ageing and Development.

[83]  Cathy H. Wu,et al.  Prediction of residue-residue contact matrix for protein-protein interaction with Fisher score features and deep learning. , 2016, Methods.

[84]  S. Imai,et al.  Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. , 2016, Cell metabolism.

[85]  R. W. Hansen,et al.  Journal of Health Economics , 2016 .

[86]  B. Gregory,et al.  Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. , 2016, Cell metabolism.

[87]  P. Chiao,et al.  Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer. , 2016, Cancer letters.

[88]  W. Tao,et al.  BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy* , 2016, The Journal of Biological Chemistry.

[89]  Sergey Plis,et al.  Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data. , 2016, Molecular pharmaceutics.

[90]  D. Seals,et al.  Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice , 2016, Aging cell.

[91]  Sumudu P Leelananda,et al.  Computational methods in drug discovery , 2016, Beilstein journal of organic chemistry.

[92]  P. Sutovsky,et al.  Autophagy and ubiquitin–proteasome system contribute to sperm mitophagy after mammalian fertilization , 2016, Proceedings of the National Academy of Sciences.

[93]  L. Ferrucci,et al.  Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. , 2016, Cell metabolism.

[94]  L. Tsai,et al.  The road to restoring neural circuits for the treatment of Alzheimer's disease , 2016, Nature.

[95]  R. Aebersold,et al.  NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice , 2016, Science.

[96]  T. Sakurai,et al.  Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death , 2016, Brain Research.

[97]  Mark S. Schmidt,et al.  Nicotinamide riboside is uniquely and orally bioavailable in mice and humans , 2016, Nature Communications.

[98]  M. Mattson,et al.  Nuclear DNA damage signalling to mitochondria in ageing , 2016, Nature Reviews Molecular Cell Biology.

[99]  F. Flamigni,et al.  Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms. , 2016, Biochimica et biophysica acta.

[100]  M. Mattson,et al.  NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. , 2016, Cell metabolism.

[101]  J. Reid,et al.  CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. , 2016, Cell metabolism.

[102]  Qian Cai,et al.  Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions , 2017, Neuron.

[103]  M. Mattson,et al.  DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease , 2016, Aging cell.

[104]  William B. Mair,et al.  Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. , 2017, Cell metabolism.

[105]  Z. Yao,et al.  Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease , 2017, Neuroscience Letters.

[106]  S. Park,et al.  Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy. , 2017, Antioxidants & redox signaling.

[107]  V. Bohr,et al.  Genome instability in Alzheimer disease , 2017, Mechanisms of Ageing and Development.

[108]  A. Reichert,et al.  SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy , 2017, Aging.

[109]  Lixuan Zhan,et al.  Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats , 2017, Cell Death & Disease.

[110]  Jun Ren,et al.  Abstract 16595: NAD+ Precursor Nicotinamide Riboside Alleviates Alcoholic Cardiomyopathy via Mitophagy Induction: A Novel SIRT3-PGAM5-FUNDC1 Axis , 2017 .

[111]  V. Bohr,et al.  NAD+: The convergence of DNA repair and mitophagy , 2017, Autophagy.

[112]  M. Mattson,et al.  NAD+ in Aging: Molecular Mechanisms and Translational Implications. , 2017, Trends in molecular medicine.

[113]  M. Z. Cader,et al.  Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms , 2017, Trends in Neurosciences.

[114]  J. Auwerx,et al.  Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity , 2017, Nature.

[115]  J. Auwerx,et al.  Modulating NAD+ metabolism, from bench to bedside , 2017, The EMBO journal.

[116]  Matthew J. Rardin,et al.  Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain , 2017, The Journal of Biological Chemistry.

[117]  Polina Mamoshina,et al.  Design of efficient computational workflows for in silico drug repurposing. , 2017, Drug discovery today.

[118]  Jian Peng,et al.  A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information , 2017, Nature Communications.

[119]  V. Bohr,et al.  Mitophagy in neurodegeneration and aging , 2017, Neurochemistry International.

[120]  Zhen Li,et al.  Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model , 2016, bioRxiv.

[121]  Hyunju Lee,et al.  An analysis of disease-gene relationship from Medline abstracts by DigSee , 2017, Scientific Reports.

[122]  L. Guarente,et al.  Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study , 2017, npj Aging and Mechanisms of Disease.

[123]  Artem Sevastopolsky,et al.  PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging , 2018, Aging.

[124]  A. Prescott,et al.  Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand , 2018, Cell metabolism.

[125]  Mark S. Schmidt,et al.  Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. , 2018, Cell metabolism.

[126]  M. McQueen,et al.  Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults , 2018, Nature Communications.

[127]  R. Shaw,et al.  AMPK: guardian of metabolism and mitochondrial homeostasis , 2017, Nature Reviews Molecular Cell Biology.

[128]  Cong Zhao,et al.  Long noncoding RNA MEG3 inhibits proliferation and migration but induces autophagy by regulation of Sirt7 and PI3K/AKT/mTOR pathway in glioma cells , 2018, Journal of cellular biochemistry.

[129]  D. Sinclair,et al.  Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. , 2018, Cell metabolism.

[130]  J. Baur,et al.  NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. , 2017, Cell metabolism.

[131]  Mark S. Schmidt,et al.  A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. , 2018, The American journal of clinical nutrition.

[132]  G. Bartolucci,et al.  Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites. , 2018, Cell chemical biology.

[133]  Camille Carroll,et al.  Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning , 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[134]  D. Sabatini,et al.  RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway , 2018, Science Advances.

[135]  Xudong Huang,et al.  Deep learning and virtual drug screening , 2018, Future medicinal chemistry.

[136]  A. Zhavoronkov,et al.  Machine Learning on Human Muscle Transcriptomic Data for Biomarker Discovery and Tissue-Specific Drug Target Identification , 2018, Front. Genet..

[137]  M. Mattson,et al.  NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency , 2018, Proceedings of the National Academy of Sciences.

[138]  M. Pérez,et al.  Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration , 2018, Front. Neurosci..

[139]  Suryanarayana Yaddanapudi,et al.  Changing Trends in Computational Drug Repositioning , 2018, Pharmaceuticals.

[140]  A. Whitworth,et al.  The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease. , 2018, Cell reports.

[141]  L. Partridge,et al.  Facing up to the global challenges of ageing , 2018, Nature.

[142]  K. Lim,et al.  PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy , 2018, Cell Research.

[143]  Nektarios Tavernarakis,et al.  Mechanisms of mitophagy in cellular homeostasis, physiology and pathology , 2018, Nature Cell Biology.

[144]  Axel Schumacher,et al.  Epigenetics of Aging and Longevity , 2018 .

[145]  Keisuke Yaku,et al.  NAD metabolism: Implications in aging and longevity , 2018, Ageing Research Reviews.

[146]  S. Ono,et al.  The Current Status of Drug Discovery and Development as Originated in United States Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development , 2018, Clinical and translational science.

[147]  M. Z. Cader,et al.  Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease , 2019, Nature Neuroscience.

[148]  O. Naveiras,et al.  The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. , 2019, Cell stem cell.

[149]  G. Brewer,et al.  Global Metabolic Shifts in Age and Alzheimer’s Disease Mouse Brains Pivot at NAD+/NADH Redox Sites , 2019, Journal of Alzheimer's disease : JAD.

[150]  M. Mattson,et al.  NAD+ in Brain Aging and Neurodegenerative Disorders. , 2019, Cell metabolism.

[151]  J. Bertran-Gonzalez,et al.  Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria , 2018, The EMBO journal.

[152]  Anastasios Bezerianos,et al.  A Network-Based Perspective in Alzheimer's Disease: Current State and an Integrative Framework , 2019, IEEE Journal of Biomedical and Health Informatics.

[153]  T. Fukumoto,et al.  NAD+ metabolism governs the proinflammatory senescence-associated secretome , 2019, Nature Cell Biology.

[154]  I. Heiland,et al.  Keeping the balance in NAD metabolism. , 2019, Biochemical Society transactions.

[155]  World Population Prospects 2019: Highlights , 2019, Statistical Papers - United Nations (Ser. A), Population and Vital Statistics Report.

[156]  Han-Ming Shen,et al.  Post-translational Modifications of Key Machinery in the Control of Mitophagy. , 2019, Trends in biochemical sciences.

[157]  E. Fang.  Mitophagy and NAD+ inhibit Alzheimer disease , 2019, Autophagy.

[158]  Nektarios Tavernarakis,et al.  Mitophagy and Neuroprotection. , 2019, Trends in molecular medicine.

[159]  L. Ferrucci,et al.  Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle. , 2019, Analytical biochemistry.

[160]  H. Nilsen,et al.  Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease , 2019, Neurochemistry International.

[161]  Bin Li,et al.  Applications of machine learning in drug discovery and development , 2019, Nature Reviews Drug Discovery.

[162]  E. Ropelle,et al.  NAD+ precursor increases aerobic performance in mice , 2019, European Journal of Nutrition.

[163]  L. Volpicelli-Daley,et al.  Pα-syn* mitotoxicity is linked to MAPK activation and involves tau phosphorylation and aggregation at the mitochondria , 2019, Neurobiology of Disease.

[164]  Li Wang,et al.  LRPPRC: A Multifunctional Protein Involved in Energy Metabolism and Human Disease , 2019, Front. Physiol..

[165]  Alex Zhavoronkov,et al.  Artificial intelligence for aging and longevity research: Recent advances and perspectives , 2019, Ageing Research Reviews.

[166]  P. Kapahi,et al.  From discoveries in ageing research to therapeutics for healthy ageing , 2019, Nature.

[167]  Mark S. Schmidt,et al.  Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures , 2019, Cell reports.

[168]  M. Beal,et al.  PGC-1α, Sirtuins and PARPs in Huntington’s Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All , 2019, Neurochemical Research.