Zazen meditation and no-task resting EEG compared with LORETA intracortical source localization

Abstract Meditation is a self-induced and willfully initiated practice that alters the state of consciousness. The meditation practice of Zazen, like many other meditation practices, aims at disregarding intrusive thoughts while controlling body posture. It is an open monitoring meditation characterized by detached moment-to-moment awareness and reduced conceptual thinking and self-reference. Which brain areas differ in electric activity during Zazen compared to task-free resting? Since scalp electroencephalography (EEG) waveforms are reference-dependent, conclusions about the localization of active brain areas are ambiguous. Computing intracerebral source models from the scalp EEG data solves this problem. In the present study, we applied source modeling using low resolution brain electromagnetic tomography (LORETA) to 58-channel scalp EEG data recorded from 15 experienced Zen meditators during Zazen and no-task resting. Zazen compared to no-task resting showed increased alpha-1 and alpha-2 frequency activity in an exclusively right-lateralized cluster extending from prefrontal areas including the insula to parts of the somatosensory and motor cortices and temporal areas. Zazen also showed decreased alpha and beta-2 activity in the left angular gyrus and decreased beta-1 and beta-2 activity in a large bilateral posterior cluster comprising the visual cortex, the posterior cingulate cortex and the parietal cortex. The results include parts of the default mode network and suggest enhanced automatic memory and emotion processing, reduced conceptual thinking and self-reference on a less judgmental, i.e., more detached moment-to-moment basis during Zazen compared to no-task resting.

[1]  Dustin Scheinost,et al.  Real-time fMRI links subjective experience with brain activity during focused attention , 2013, NeuroImage.

[2]  A. Kleinschmidt,et al.  Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at rest , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Raichle,et al.  Integration of emotion and cognition in the lateral prefrontal cortex , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Ernst Fernando Lopes Da Silva Niedermeyer,et al.  Electroencephalography, basic principles, clinical applications, and related fields , 1982 .

[5]  G. Pagnoni,et al.  “Thinking about Not-Thinking”: Neural Correlates of Conceptual Processing during Zen Meditation , 2008, PloS one.

[6]  I. Johnsrude,et al.  The problem of functional localization in the human brain , 2002, Nature Reviews Neuroscience.

[7]  Dimitri Van De Ville,et al.  BOLD correlates of EEG topography reveal rapid resting-state network dynamics , 2010, NeuroImage.

[8]  Leslie G. Ungerleider.  Two cortical visual systems , 1982 .

[9]  D.B. Geselowitz,et al.  The zero of potential , 1998, IEEE Engineering in Medicine and Biology Magazine.

[10]  Judson A. Brewer,et al.  Effortless awareness: using real time neurofeedback to investigate correlates of posterior cingulate cortex activity in meditators' self-report , 2013, Front. Hum. Neurosci..

[11]  R. Zhou,et al.  Individual Differences in Automatic Emotion Regulation Affect the Asymmetry of the LPP Component , 2014, PloS one.

[12]  P. Ruby,et al.  What is self-specific? Theoretical investigation and critical review of neuroimaging results. , 2009, Psychological review.

[13]  M. Goodale.  Transforming vision into action , 2011, Vision Research.

[14]  S. Kosslyn,et al.  The role of area 17 in visual imagery: convergent evidence from PET and rTMS. , 1999, Science.

[15]  Arnoud Arntz,et al.  The Role of Right Prefrontal and Medial Cortex in Response Inhibition: Interfering with Action Restraint and Action Cancellation Using Transcranial Magnetic Brain Stimulation , 2014, Journal of Cognitive Neuroscience.

[16]  D. Lehmann,et al.  Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[17]  G. Comi,et al.  IFCN standards for digital recording of clinical EEG. International Federation of Clinical Neurophysiology. , 1998, Electroencephalography and clinical neurophysiology.

[18]  J. Polich,et al.  Meditation states and traits: EEG, ERP, and neuroimaging studies. , 2013 .

[19]  E. Basar,et al.  A possible role of evoked alpha in primary sensory processing: common properties of cat intracranial recordings and human EEG and MEG. , 1997, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[20]  M. Greicius,et al.  Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI , 2004, Proc. Natl. Acad. Sci. USA.

[21]  G. Shulman,et al.  Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M M Mesulam,et al.  Large‐scale neurocognitive networks and distributed processing for attention, language, and memory , 1990, Annals of neurology.

[23]  Lorena R. R. Gianotti,et al.  Brain sources of EEG gamma frequency during volitionally meditation-induced, altered states of consciousness, and experience of the self , 2001, Psychiatry Research: Neuroimaging.

[24]  Christina F. Lavallee,et al.  Intracerebral source generators characterizing concentrative meditation , 2011, Cognitive Processing.

[25]  M. Bader,et al.  Topography of event-related potentials elicited by visual emotional stimuli. , 1991, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[26]  Akira Kasamatsu,et al.  AN ELECTROENCEPHALOGRAPHIC STUDY ON THE ZEN MEDITATION (ZAZEN) , 1966, Folia psychiatrica et neurologica japonica.

[27]  Masashi Nishio,et al.  Quantitative EEG Study on Zen Meditation (Zazen) , 1994 .

[28]  Dietrich Lehmann,et al.  Meditators and Non-Meditators: EEG Source Imaging During Resting , 2009, Brain Topography.

[29]  D. Schacter,et al.  The Brain's Default Network , 2008, Annals of the New York Academy of Sciences.

[30]  A. Burgess,et al.  Paradox lost? Exploring the role of alpha oscillations during externally vs. internally directed attention and the implications for idling and inhibition hypotheses. , 2003, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[31]  Daniel Strüber,et al.  Necker cube reversals during long-term EEG recordings: sub-bands of alpha activity. , 2006, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[32]  Daniel Ruchkin.  EEG coherence. , 2005, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[33]  J. Palva,et al.  New vistas for α-frequency band oscillations , 2007, Trends in Neurosciences.

[34]  P. Lo,et al.  EEG dynamics of experienced Zen meditation practitioners probed by complexity index and spectral measure , 2009, Journal of medical engineering & technology.

[35]  S. Rauch,et al.  Meditation experience is associated with increased cortical thickness , 2005, Neuroreport.

[36]  A. Goldstein,et al.  Mindfulness-induced changes in gamma band activity – Implications for the default mode network, self-reference and attention , 2012, Clinical Neurophysiology.

[37]  Narayanan Srinivasan,et al.  The exploration of meditation in the neuroscience of attention and consciousness , 2010, Cognitive Processing.

[38]  J. Shear,et al.  Focused attention, open monitoring and automatic self-transcending: Categories to organize meditations from Vedic, Buddhist and Chinese traditions , 2010, Consciousness and Cognition.

[39]  Thomas E. Nichols,et al.  Nonparametric permutation tests for functional neuroimaging: A primer with examples , 2002, Human brain mapping.

[40]  W. Klimesch,et al.  EEG alpha oscillations: The inhibition–timing hypothesis , 2007, Brain Research Reviews.

[41]  W. Strik,et al.  EEG signs of vigilance fluctuations preceding perceptual flips in multistable illusionary motion. , 1999, Neuroreport.

[42]  L. Aftanas,et al.  Impact of regular meditation practice on EEG activity at rest and during evoked negative emotions , 2005, The International journal of neuroscience.

[43]  Arnaud Delorme,et al.  Occipital gamma activation during Vipassana meditation , 2009, Cognitive Processing.

[44]  G L Shulman,et al.  INAUGURAL ARTICLE by a Recently Elected Academy Member:A default mode of brain function , 2001 .

[45]  Dietrich Lehmann,et al.  Reduced functional connectivity between cortical sources in five meditation traditions detected with lagged coherence using EEG tomography , 2012, NeuroImage.

[46]  M. Goodale,et al.  Separate visual pathways for perception and action , 1992, Trends in Neurosciences.

[47]  J. Palva,et al.  New vistas for alpha-frequency band oscillations. , 2007, Trends in neurosciences.

[48]  Hillary S. Schaefer,et al.  Neural correlates of attentional expertise in long-term meditation practitioners , 2007, Proceedings of the National Academy of Sciences.

[49]  S. Kosslyn,et al.  Visual Mental Imagery Activates Topographically Organized Visual Cortex: PET Investigations , 1993, Journal of Cognitive Neuroscience.

[50]  Adam R. Walczak,et al.  At the heart of the ventral attention system: The right anterior insula , 2009, Human brain mapping.

[51]  Scott T. Grafton,et al.  Wandering Minds: The Default Network and Stimulus-Independent Thought , 2007, Science.

[52]  Matthias M. Müller,et al.  Effects of emotional arousal in the cerebral hemispheres: a study of oscillatory brain activity and event-related potentials , 2001, Clinical Neurophysiology.

[53]  N. Farb,et al.  Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference. , 2007, Social cognitive and affective neuroscience.

[54]  R. Mansfield,et al.  Analysis of visual behavior , 1982 .

[55]  J. H. Austin.  Zen and the brain: mutually illuminating topics , 2013, Front. Psychol..

[56]  Yoshihiro Kitamura,et al.  Medial Prefrontal Cortex and Anterior Cingulate Cortex in the Generation of Alpha Activity Induced by Transcendental Meditation : A Magnetoencephalographic Study , 2006 .

[57]  D. Vernon,et al.  Interpreting EEG alpha activity , 2014, Neuroscience & Biobehavioral Reviews.

[58]  L. Michels,et al.  Coupling Between Resting Cerebral Perfusion and EEG , 2012, Brain Topography.

[59]  Zoran Josipovic.  Duality and nonduality in meditation research , 2010, Consciousness and Cognition.

[60]  J. A. Frost,et al.  Conceptual Processing during the Conscious Resting State: A Functional MRI Study , 1999, Journal of Cognitive Neuroscience.

[61]  T. Koenig,et al.  Low resolution brain electromagnetic tomography (LORETA) functional imaging in acute, neuroleptic-naive, first-episode, productive schizophrenia , 1999, Psychiatry Research: Neuroimaging.

[62]  D. Shapiro,et al.  Physiological responses to clicks during Zen, Yoga, and TM meditation. , 1981, Psychophysiology.

[63]  A. Cavanna,et al.  The precuneus: a review of its functional anatomy and behavioural correlates. , 2006, Brain : a journal of neurology.

[64]  T. Johnstone,et al.  Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise , 2008, PloS one.

[65]  N. Thakor,et al.  Quantitative EEG analysis methods and clinical applications , 2009 .

[66]  R. Walsh,et al.  An analysis of recent meditation research and suggestions for future directions , 2003 .

[67]  高橋 哲也,et al.  Changes in EEG and autonomic nervous activity during meditation and their association with personality traits , 2004 .

[68]  Andris K. TebeTcis,et al.  A Controlled Study of the EEG During Transcendental Meditation: Comparison With Hypnosis , 1975 .

[69]  W M Herrmann,et al.  Reflections on the topics: EEG frequency bands and regulation of vigilance. , 1979, Pharmakopsychiatrie, Neuro-Psychopharmakologie.

[70]  Georg Northoff,et al.  How is our self related to midline regions and the default-mode network? , 2011, NeuroImage.

[71]  W. Sato,et al.  Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure. , 2001, Brain research. Cognitive brain research.

[72]  R D Pascual-Marqui,et al.  Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. , 2002, Methods and findings in experimental and clinical pharmacology.

[73]  W. Klimesch.  EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis , 1999, Brain Research Reviews.

[74]  T. Jung,et al.  Changes in alertness are a principal component of variance in the EEG spectrum , 1995, Neuroreport.

[75]  Reply to Josipovic: Duality and non-duality in meditation research , 2010, Consciousness and Cognition.

[76]  Xinjun Yu,et al.  Activation of the anterior prefrontal cortex and serotonergic system is associated with improvements in mood and EEG changes induced by Zen meditation practice in novices. , 2011, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[77]  M. Corbetta,et al.  Episodic Memory Retrieval, Parietal Cortex, and the Default Mode Network: Functional and Topographic Analyses , 2011, The Journal of Neuroscience.

[78]  J. Brewer,et al.  Human Neuroscience Hypothesis and Theory Article , 2022 .

[79]  L. J. Chapman,et al.  The measurement of handedness , 1987, Brain and Cognition.

[80]  A. Lutz,et al.  Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[81]  A K Tebēcis.  A controlled study of the EEG during transcendental meditation: comparison with hypnosis. , 1975, Folia psychiatrica et neurologica japonica.

[82]  A. Walker.  Electroencephalography, Basic Principles, Clinical Applications and Related Fields , 1982 .

[83]  S Karakas,et al.  A descriptive framework for information processing: an integrative approach. , 1997, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[84]  J. Gray,et al.  Meditation experience is associated with differences in default mode network activity and connectivity , 2011, Proceedings of the National Academy of Sciences.

[85]  Meditating Selflessly: Practical Neural Zen , 2011 .

[86]  Bruce R. Dunn,et al.  Concentration and Mindfulness Meditations: Unique Forms of Consciousness? , 1999, Applied psychophysiology and biofeedback.

[87]  M. Seghier,et al.  Functional Subdivisions in the Left Angular Gyrus Where the Semantic System Meets and Diverges from the Default Network , 2010, The Journal of Neuroscience.

[88]  G. Comi,et al.  IFCN standards for digital recording of clinical EEG. The International Federation of Clinical Neurophysiology. , 1998, Electroencephalography and clinical neurophysiology. Supplement.

[89]  Frederick Travis,et al.  CROSS-SECTIONAL AND LONGITUDINAL STUDY OF EFFECTS OF TRANSCENDENTAL MEDITATION PRACTICE ON INTERHEMISPHERIC FRONTAL ASYMMETRY AND FRONTAL COHERENCE , 2006, The International journal of neuroscience.

[90]  H. Sackeim,et al.  Parietal cortex and representation of the mental Self. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[91]  Maxwell Rainforth,et al.  A self-referential default brain state: patterns of coherence, power, and eLORETA sources during eyes-closed rest and Transcendental Meditation practice , 2010, Cognitive Processing.