The Role of the Right Temporoparietal Junction in Social Interaction: How Low-Level Computational Processes Contribute to Meta-Cognition

Accumulating evidence from cognitive neuroscience indicates that the right inferior parietal cortex, at the junction with the posterior temporal cortex, plays a critical role in various aspects of social cognition such as theory of mind and empathy. With a quantitative meta-analysis of 70 functional neuroimaging studies, the authors demonstrate that this area is also engaged in lower-level (bottom-up) computational processes associated with the sense of agency and reorienting attention to salient stimuli. It is argued that this domain-general computational mechanism is crucial for higher level social cognitive processing. NEUROSCIENTIST 13(6): 580—593, 2007. DOI: 10.1177/1073858407304654

[1]  W. Umbreit.  V – Specificity of Action , 1954 .

[2]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[3]  Richard S. J. Frackowiak,et al.  Other minds in the brain: a functional imaging study of “theory of mind” in story comprehension , 1995, Cognition.

[4]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[5]  S. Aglioti,et al.  The body in the brain: neural bases of corporeal awareness , 1997, Trends in Neurosciences.

[6]  D. Brooks,et al.  A PET study of voluntary movement in schizophrenic patients experiencing passivity phenomena (delusions of alien control). , 1997, Brain : a journal of neurology.

[7]  L. Parsons,et al.  Beyond the single study: function/location metanalysis in cognitive neuroimaging , 1998, Current Opinion in Neurobiology.

[8]  E. Bullmore,et al.  Social intelligence in the normal and autistic brain: an fMRI study , 1999, The European journal of neuroscience.

[9]  J. Marshall,et al.  The neural consequences of conflict between intention and the senses. , 1999, Brain : a journal of neurology.

[10]  J. Downar,et al.  A multimodal cortical network for the detection of changes in the sensory environment , 2000, Nature Neuroscience.

[11]  C. Frith,et al.  Reading the mind in cartoons and stories: an fMRI study of ‘theory of mind’ in verbal and nonverbal tasks , 2000, Neuropsychologia.

[12]  J. Decety,et al.  Effect of subjective perspective taking during simulation of action: a PET investigation of agency , 2001, Nature Neuroscience.

[13]  Jonathan D. Cohen,et al.  An fMRI Investigation of Emotional Engagement in Moral Judgment , 2001, Science.

[14]  David C. Van Essen,et al.  Application of Information Technology: An Integrated Software Suite for Surface-based Analyses of Cerebral Cortex , 2001, J. Am. Medical Informatics Assoc..

[15]  J. Downar,et al.  The Effect of Task Relevance on the Cortical Response to Changes in Visual and Auditory Stimuli: An Event-Related fMRI Study , 2001, NeuroImage.

[16]  T. Braver,et al.  Anterior cingulate cortex and response conflict: effects of frequency, inhibition and errors. , 2001, Cerebral cortex.

[17]  M. Chicurel.  Windows on the brain , 2001, Nature.

[18]  Ivanei E. Bramati,et al.  The Neural Correlates of Moral Sensitivity: A Functional Magnetic Resonance Imaging Investigation of Basic and Moral Emotions , 2002, The Journal of Neuroscience.

[19]  M. Corbetta,et al.  Control of goal-directed and stimulus-driven attention in the brain , 2002, Nature Reviews Neuroscience.

[20]  David C. Van Essen,et al.  Windows on the brain: the emerging role of atlases and databases in neuroscience , 2002, Current Opinion in Neurobiology.

[21]  D. V. van Essen,et al.  Windows on the brain: the emerging role of atlases and databases in neuroscience , 2002, Current Opinion in Neurobiology.

[22]  J. Downar,et al.  A cortical network sensitive to stimulus salience in a neutral behavioral context across multiple sensory modalities. , 2002, Journal of neurophysiology.

[23]  C. Frith,et al.  Experiencing Oneself vs Another Person as Being the Cause of an Action: The Neural Correlates of the Experience of Agency , 2002, NeuroImage.

[24]  Thomas E. Nichols,et al.  Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate , 2002, NeuroImage.

[25]  Marc Jeannerod,et al.  Modulating the experience of agency: a positron emission tomography study , 2003, NeuroImage.

[26]  C. Frith,et al.  Self-awareness and action , 2003, Current Opinion in Neurobiology.

[27]  R Saxe,et al.  People thinking about thinking people The role of the temporo-parietal junction in “theory of mind” , 2003, NeuroImage.

[28]  J. Decety,et al.  What you believe versus what you think they believe: a neuroimaging study of conceptual perspective‐taking , 2003, The European journal of neuroscience.

[29]  J. Sommerville,et al.  Shared representations between self and other: a social cognitive neuroscience view , 2003, Trends in Cognitive Sciences.

[30]  Michael Erb,et al.  The neural correlates of perceiving one's own movements , 2003, NeuroImage.

[31]  Andrew N. Meltzoff,et al.  The neural bases of cooperation and competition: an fMRI investigation , 2004, NeuroImage.

[32]  Jonathan D. Cohen,et al.  Opposing BOLD responses to reciprocated and unreciprocated altruism in putative reward pathways , 2004, Neuroreport.

[33]  J. Decety,et al.  The functional architecture of human empathy. , 2004, Behavioral and cognitive neuroscience reviews.

[34]  Kiyotaka Nemoto,et al.  The neural network for the mirror system and mentalizing in normally developed children: an fMRI study , 2004, Neuroreport.

[35]  J. O'Doherty,et al.  Empathy for Pain Involves the Affective but not Sensory Components of Pain , 2004, Science.

[36]  J. Decety,et al.  Motor cognition: a new paradigm to study self–other interactions , 2004, Current Opinion in Neurobiology.

[37]  M. Jeannerod,et al.  Neural correlates of action attribution in schizophrenia , 2004, Psychiatry Research: Neuroimaging.

[38]  R. Saxe,et al.  Making sense of another mind: The role of the right temporo-parietal junction , 2005, Neuropsychologia.

[39]  Angela M. Uecker,et al.  ALE meta‐analysis: Controlling the false discovery rate and performing statistical contrasts , 2005, Human brain mapping.

[40]  Angela R. Laird,et al.  BrainMap , 2007, Neuroinformatics.

[41]  Amishi P. Jha,et al.  Viewing facial expressions of pain engages cortical areas involved in the direct experience of pain , 2005, NeuroImage.

[42]  O. Blanke,et al.  The Out-of-Body Experience: Disturbed Self-Processing at the Temporo-Parietal Junction , 2005, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[43]  R. Henson.  What can Functional Neuroimaging Tell the Experimental Psychologist? , 2005, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[44]  J. Sommerville,et al.  Weaving the fabric of social interaction: Articulating developmental psychology and cognitive neuroscience in the domain of motor cognition , 2006, Psychonomic bulletin & review.

[45]  Michael J. Brammer,et al.  The role of ‘shared representations’ in social perception and empathy: An fMRI study , 2006, NeuroImage.

[46]  Hiroshi Matsuda,et al.  Impaired self-awareness and theory of mind: An fMRI study of mentalizing in alexithymia , 2006, NeuroImage.

[47]  J. Decety,et al.  The power of simulation: Imagining one's own and other's behavior , 2006, Brain Research.

[48]  G. R. Fink,et al.  The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability , 2006, Neuroscience.

[49]  A. Meltzoff,et al.  Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain , 2006, Neuropsychologia.

[50]  Rebecca Elliott,et al.  Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task , 2006, NeuroImage.

[51]  J. Decety,et al.  Human Empathy Through the Lens of Social Neuroscience , 2006, TheScientificWorldJournal.

[52]  Lindsey J. Powell,et al.  It's the Thought That Counts , 2006, Psychological science.

[53]  Istvan Molnar-Szakacs,et al.  rTMS to the right inferior parietal lobule disrupts self-other discrimination. , 2006, Social cognitive and affective neuroscience.

[54]  R. Saxe.  Uniquely human social cognition , 2006, Current Opinion in Neurobiology.

[55]  D. Perrett,et al.  Neural mechanisms of imitation and ‘mirror neuron’ functioning in autistic spectrum disorder , 2006, Neuropsychologia.

[56]  Maurizio Corbetta,et al.  Visuospatial reorienting signals in the human temporo‐parietal junction are independent of response selection , 2006, The European journal of neuroscience.

[57]  M. Coltheart.  What has Functional Neuroimaging told us about the Mind (so far)? (Position Paper Presented to the European Cognitive Neuropsychology Workshop, Bressanone, 2005) , 2006, Cortex.

[58]  Philip Gerrans,et al.  What's domain-specific about theory of mind? , 2006, Social neuroscience.

[59]  Claus Lamm,et al.  The Neural Substrate of Human Empathy: Effects of Perspective-taking and Cognitive Appraisal , 2007, Journal of Cognitive Neuroscience.