Synthesis and Antiviral Activity of Some Fluorinated Nucleotide Derivatives

Abstract A number of 3′-fluoro-3′-deoxythymidine 5′-phosphonates and nucleoside 5′-phosphorofluoridates were prepared to study their ability to inhibit replication of HIV-1. Compounds, the 5′-phosphorofluoridates of 3′-azido-3′-deoxythymidine (VIIIc), 3′-fluoro-3′-deoxythymidine (VIIId) and 3′-deoxy-2′,3′-didehydrothymidine (VIIIe), exhibit potent anti-HIV-1 activities.

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