Bootstrapping conceptual deduction using physical connection: rethinking frontal cortex

The age at which infants can demonstrate the ability to deduce abstract rules can be reduced by more than half, from 21 months to 9 months. The key is to introduce a physical connection between the items to be conceptually related. I argue here that making the same change in how items are presented might also help some preschoolers with learning delays, especially some children with autism. I also suggest that the roles of premotor and ventrolateral prefrontal cortices in deducing abstract rules might have been misinterpreted behaviorally and anatomically. The crucial brain region may be the periarcuate, which partially overlaps both premotor and lateral prefrontal cortex. The cognitive ability made possible by this region might be something far more elementary than previously considered: the ability to perceive conceptual connections in the absence of physical connection.

[1]  R. Passingham,et al.  The role of premotor and parietal cortex in the direction of action , 1982, Brain Research.

[2]  M. Brass,et al.  Involvement of the inferior frontal junction in cognitive control: Meta‐analyses of switching and Stroop studies , 2005, Human brain mapping.

[3]  R. E Passingham,et al.  Activations related to “mirror” and “canonical” neurones in the human brain: an fMRI study , 2003, NeuroImage.

[4]  S. Hepburn,et al.  Imitation performance in toddlers with autism and those with other developmental disorders. , 2003, Journal of child psychology and psychiatry, and allied disciplines.

[5]  J. Mazziotta,et al.  The essential role of Broca's area in imitation , 2003, The European journal of neuroscience.

[6]  Keiji Tanaka,et al.  Neuronal Correlates of Goal-Based Motor Selection in the Prefrontal Cortex , 2003, Science.

[7]  U. Frith Autism: Explaining the Enigma , 2005 .

[8]  R. Hari,et al.  Temporal dynamics of cortical representation for action. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[9]  C. Nelson,et al.  Assessment of Neuropsychological Function Through Use of the Cambridge Neuropsychological Testing Automated Battery: Performance in 4- to 12-Year-Old Children , 2002, Developmental neuropsychology.

[10]  S. Ward,et al.  Autistic Spectrum Disorder , 2004, Autism : the international journal of research and practice.

[11]  A. Cowey,et al.  On the role of posterior parietal and prefrontal cortex in visuo-spatial perception and attention , 2004, Experimental Brain Research.

[12]  F. Happé Autism: cognitive deficit or cognitive style? , 1999, Trends in Cognitive Sciences.

[13]  J. Deloache,et al.  Very young children's memory for the location of objects in a large-scale environment. , 1983, Child development.

[14]  A. Meltzoff,et al.  An fMRI study of imitation: action representation and body schema , 2005, Neuropsychologia.

[15]  G. Rizzolatti,et al.  Premotor cortex and the recognition of motor actions. , 1996, Brain research. Cognitive brain research.

[16]  M. Herrero Botín [Language and communication]. , 1984, Revista de enfermeria.

[17]  E. Miller,et al.  From rule to response: neuronal processes in the premotor and prefrontal cortex. , 2003, Journal of neurophysiology.

[18]  F. Happé Studying weak central coherence at low levels: children with autism do not succumb to visual illusions. A research note. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[19]  R. Passingham,et al.  Neural correlates of visuomotor associations. Spatial rules compared with arbitrary rules. , 2001, Experimental brain research.

[20]  G Masson,et al.  Postural effects of motion vision in young autistic children , 1995, Neuroreport.

[21]  Judy S. DeLoache,et al.  Early Understanding and Use of Symbols: The Model Model , 1995 .

[22]  M. Brass,et al.  A receptor- and cytoarchitectonic correlate of the functionally defined inferior-frontal junction area , 2004 .

[23]  George A. Miller,et al.  Language and Communication , 1951 .

[24]  Michael Petrides,et al.  Nonspatial conditional learning impaired in patients with unilateral frontal but not unilateral temporal lobe excisions , 1990, Neuropsychologia.

[25]  G. Dawson,et al.  Neurocognitive function and joint attention ability in young children with autism spectrum disorder versus developmental delay. , 2002, Child development.

[26]  A. Diamond,et al.  Rate of Maturation of the Hippocampus and the Developmental Progression of Children's Performance on the Delayed Non‐Matching to Sample and Visual Paired Comparison Tasks a , 1990, Annals of the New York Academy of Sciences.

[27]  M. Mishkin,et al.  Non-spatial memory after selective prefrontal lesions in monkeys , 1978, Brain Research.

[28]  J. Russell,et al.  The execution of arbitrary procedures by children with autism , 2001, Development and Psychopathology.

[29]  U. Frith,et al.  Language and communication in autistic disorders. , 1994, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[30]  M. Petrides The effect of periarcuate lesions in the monkey on the performance of symmetrically and asymmetrically reinforced visual and auditory go, no- go tasks , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[31]  R. Passingham,et al.  Ventral Prefrontal Cortex Is Not Essential for Working Memory , 1997, The Journal of Neuroscience.

[32]  R. Hari,et al.  Abnormal imitation‐related cortical activation sequences in Asperger's syndrome , 2004, Annals of neurology.

[33]  Discrimination of colored food and food signs by primates. , 1953, Journal of comparative and physiological psychology.

[34]  E. Alberts,et al.  Transposition in children as a function of age. , 1951, Journal of experimental psychology.

[35]  D. Crowne,et al.  Unilateral periarcuate and posterior parietal lesions impair conditional position discrimination learning in the monkey , 1989, Neuropsychologia.

[36]  J. Mazziotta,et al.  Cortical mechanisms of human imitation. , 1999, Science.

[37]  Mortimer Mishkin,et al.  Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys , 1986, Behavioural Brain Research.

[38]  M. Petrides Visuo-motor conditional associative learning after frontal and temporal lesions in the human brain , 1997, Neuropsychologia.

[39]  A. Churchland,et al.  Early developments in the ability to understand the relation between stimulus and reward. , 1999, Developmental psychology.

[40]  M. Jarvik Discrimination of colored food signs by primates. , 1953 .

[41]  Helen Tager-Flusberg,et al.  Semantic processing in the free recall of autistic children: Further evidence for a cognitive deficit , 1991 .

[42]  E. Miller,et al.  Neural circuits subserving the retrieval and maintenance of abstract rules. , 2003, Journal of neurophysiology.

[43]  M. Petrides Deficits in non-spatial conditional associative learning after periarcuate lesions in the monkey , 1985, Behavioural Brain Research.

[44]  M. Brass,et al.  The role of the inferior frontal junction area in cognitive control , 2005, Trends in Cognitive Sciences.

[45]  R. Hobson,et al.  Imitation and identification in autism. , 1999, Journal of child psychology and psychiatry, and allied disciplines.

[46]  R. Elliott,et al.  Differential Neural Responses during Performance of Matching and Nonmatching to Sample Tasks at Two Delay Intervals , 1999, The Journal of Neuroscience.

[47]  A. Diamond Evidence of robust recognition memory early in life even when assessed by reaching behavior. , 1995, Journal of experimental child psychology.

[48]  J. Fagan,et al.  Infants' delayed recognition memory and forgetting. , 1973, Journal of experimental child psychology.

[49]  R. Passingham,et al.  Premotor cortex and the conditions for movement in monkeys (Macaca fascicularis) , 1985, Behavioural Brain Research.

[50]  M. Petrides Deficits on conditional associative-learning tasks after frontal- and temporal-lobe lesions in man , 1985, Neuropsychologia.

[51]  A. Whiten,et al.  A Systematic Review of Action Imitation in Autistic Spectrum Disorder , 2004, Journal of autism and developmental disorders.

[52]  M. Jarvik Simple color discrimination in chimpanzees: effect of varying contiguity between cue and incentive. , 1956, Journal of comparative and physiological psychology.

[53]  R. Passingham,et al.  Specialisation within the prefrontal cortex: the ventral prefrontal cortex and associative learning , 2000, Experimental Brain Research.

[54]  L. Mottron Matching Strategies in Cognitive Research with Individuals with High-Functioning Autism: Current Practices, Instrument Biases, and Recommendations , 2004, Journal of autism and developmental disorders.

[55]  W. Overman Performance on Traditional Matching to Sample, Non‐Matching to Sample, and Object Discrimination Tasks by 12‐ to 32‐Month‐Old Children , 1990, Annals of the New York Academy of Sciences.

[56]  Mortimer Mishkin,et al.  The role of the inferior prefrontal convexity in performance of delayed nonmatching-to-sample , 1991, Neuropsychologia.

[57]  M. Mishkin,et al.  Effects of object preferences and aversions on discrimination learning in monkeys with frontal lesions. , 1961 .

[58]  Lawrence R. Wheeless,et al.  A Research Note , 1982 .

[59]  J. Mazziotta,et al.  Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[60]  L. Squire,et al.  Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia. , 1985, Behavioral neuroscience.

[61]  M. Honda,et al.  The role of rostral Brodmann area 6 in mental-operation tasks: an integrative neuroimaging approach. , 2002, Cerebral cortex.

[62]  Bao-Ming Li,et al.  Deficit in conditional visuomotor learning by local infusion of bicuculline into the ventral prefrontal cortex in monkeys , 2000, The European journal of neuroscience.

[63]  H. E. Rosvold,et al.  Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. , 1970, Experimental neurology.

[64]  J. Bachevalier,et al.  Object recognition versus object discrimination: comparison between human infants and infant monkeys. , 1992, Behavioral neuroscience.

[65]  D. Pandya,et al.  Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey , 2002, The European journal of neuroscience.

[66]  M. Kuenne Experimental investigation of the relation of language to transposition behavior in young children. , 1946 .

[67]  A. Diamond,et al.  Young children's performance on a task sensitive to the memory functions of the medial temporal lobe in adults--the delayed nonmatching-to-sample task--reveals problems that are due to non-memory-related task demands. , 1994, Behavioral neuroscience.

[68]  A. Diamond,et al.  Early success in using the relation between stimuli and rewards to deduce an abstract rule: perceived physical connection is key. , 2003, Developmental psychology.

[69]  M. Petrides Motor conditional associative-learning after selective prefrontal lesions in the monkey , 1982, Behavioural Brain Research.

[70]  G. Dawson,et al.  Brief Report: Recognition Memory and Stimulus-Reward Associations: Indirect Support for the Role of Ventromedial Prefrontal Dysfunction in Autism , 2001, Journal of autism and developmental disorders.

[71]  L. Bailly Autistic spectrum disorder? , 2002, Journal of the American Academy of Child and Adolescent Psychiatry.

[72]  L. Waterhouse,et al.  Delayed match‐to‐sample performance in autistic children , 1995 .

[73]  J. Deloache Memory in very young children: Exploitation of cues to the location of a hidden object , 1986 .

[74]  J. Mazziotta,et al.  Modulation of motor and premotor activity during imitation of target-directed actions. , 2002, Cerebral cortex.