AI applications in robotics, diagnostic image analysis and precision medicine: Current limitations, future trends, guidelines on CAD systems for medicine

Abstract Background AI in medicine has been recognized by both academia and industry in revolutionizing how healthcare services will be offered by providers and perceived by all stakeholders. Objectives We aim to review recent tendencies in building AI applications for medicine and foster its further development by outlining obstacles. Sub-objectives: (1) to highlight AI techniques that we have identified as key areas of AI-related research in healthcare; (2) to offer guidelines on building reliable AI-based CAD-systems for medicine; and (3) to reveal open research questions, challenges, and directions for future research. Methods To address the tasks, we performed a systematic review of the references on the main branches of AI applications for medical purposes. We focused primarily on limitations of the reviewed studies. Conclusions This study provides a summary of AI-related research in healthcare, it discusses the challenges and proposes open research questions for further research. Robotics has taken huge leaps in improving the healthcare services in a variety of medical sectors, including oncology and surgical interventions. In addition, robots are now replacing human assistants as they learn to become more sociable and reliable. However, there are challenges that must still be addressed to enable the use of medical robots in diagnostics and interventions. AI for medical imaging eliminates subjectivity in a visual diagnostic procedure and allows for the combining of medical imaging with clinical data, lifestyle risks and demographics. Disadvantages of AI solutions for radiology include both a lack of transparency and dedication to narrowed diagnostic questions. Designing an optimal automatic classifier should incorporate both expert knowledge on a disease and state-of-the-art computer vision techniques. AI in precision medicine and oncology allows for risk stratification due to genomics aberrations discovered on molecular testing. To summarize, AI cannot substitute a medical doctor. However, medicine may benefit from robotics, a CAD, and AI-based personalized approach.

[1]  J. Seuntjens,et al.  Deep learning in head & neck cancer outcome prediction , 2019, Scientific Reports.

[2]  M. Mazurowski,et al.  Using Artificial Intelligence to Revise ACR TI-RADS Risk Stratification of Thyroid Nodules: Diagnostic Accuracy and Utility. , 2019, Radiology.

[3]  Min-Ying Su,et al.  A multi-resolution approach for spinal metastasis detection using deep Siamese neural networks , 2017, Comput. Biol. Medicine.

[4]  Shadi Albarqouni,et al.  Capsule Networks against Medical Imaging Data Challenges , 2018, CVII-STENT/LABELS@MICCAI.

[5]  A. Ng,et al.  Deep-learning-assisted diagnosis for knee magnetic resonance imaging: Development and retrospective validation of MRNet , 2018, PLoS medicine.

[6]  Michael Götz,et al.  Radiomic Machine Learning for Characterization of Prostate Lesions with MRI: Comparison to ADC Values. , 2018, Radiology.

[7]  Costantino Grana,et al.  Augmenting data with GANs to segment melanoma skin lesions , 2019, Multimedia Tools and Applications.

[8]  Joe Cecil,et al.  WITHDRAWN: An IoMT-based Cyber Training Framework for Orthopedic Surgery using Next Generation Internet Technologies , 2019, Informatics in Medicine Unlocked.

[9]  H. Aerts,et al.  Deep Learning for Fully-Automated Localization and Segmentation of Rectal Cancer on Multiparametric MR , 2017, Scientific Reports.

[10]  P. S. Hiremath,et al.  Follicle Detection and Ovarian Classification in Digital Ultrasound Images of Ovaries , 2013 .

[11]  X. Cui,et al.  Lymph Node Metastasis Prediction from Primary Breast Cancer US Images Using Deep Learning. , 2019, Radiology.

[12]  Dongxiao Zhu,et al.  SUBIC: A Supervised Bi-Clustering Approach for Precision Medicine , 2017, 2017 16th IEEE International Conference on Machine Learning and Applications (ICMLA).

[13]  Xiangyu Wang,et al.  Ensemble of 3D densely connected convolutional network for diagnosis of mild cognitive impairment and Alzheimer's disease , 2019, Neurocomputing.

[14]  J. Medaglia,et al.  Lack of group-to-individual generalizability is a threat to human subjects research , 2018, Proceedings of the National Academy of Sciences.

[15]  Ronald M. Summers,et al.  Cortical shell unwrapping for vertebral body abnormality detection on computed tomography , 2014, Comput. Medical Imaging Graph..

[16]  Zodwa Dlamini,et al.  Artificial intelligence (AI) and big data in cancer and precision oncology , 2020, Computational and structural biotechnology journal.

[17]  Massimo Filippi,et al.  Automated classification of Alzheimer's disease and mild cognitive impairment using a single MRI and deep neural networks , 2018, NeuroImage: Clinical.

[18]  Alexandros Karargyris,et al.  Feature Selection for Automatic Tuberculosis Screening in Frontal Chest Radiographs , 2018, Journal of Medical Systems.

[19]  Jianxi Yang,et al.  Statistical Pattern Recognition for Structural Health Monitoring using ESN Feature Extraction method , 2018, Int. J. Robotics Autom..

[20]  Mirko Orsini,et al.  My smart age with HIV: An innovative mobile and IoMT framework for patient's empowerment , 2017, 2017 IEEE 3rd International Forum on Research and Technologies for Society and Industry (RTSI).

[21]  Geoffrey E. Hinton,et al.  ImageNet classification with deep convolutional neural networks , 2012, Commun. ACM.

[22]  Domenico Presenza,et al.  Key challenges for developing a Socially Assistive Robotic (SAR) solution for the health sector , 2018, 2018 IEEE 23rd International Workshop on Computer Aided Modeling and Design of Communication Links and Networks (CAMAD).

[23]  Tiffany C. Kwong,et al.  Machine learning for prediction of chemoradiation therapy response in rectal cancer using pre-treatment and mid-radiation multi-parametric MRI. , 2019, Magnetic resonance imaging.

[24]  Prashansa Agrawal,et al.  Artificial Intelligence in Drug Discovery and Development , 2018 .

[25]  Ross B. Girshick,et al.  Mask R-CNN , 2017, 1703.06870.

[26]  Ghassan Hamarneh,et al.  Clinically-inspired automatic classification of ovarian carcinoma subtypes , 2016, Journal of pathology informatics.

[27]  S. U. K. Bukhari,et al.  The diagnostic evaluation of Convolutional Neural Network (CNN) for the assessment of chest X-ray of patients infected with COVID-19 , 2020, medRxiv.

[28]  A. Jemal,et al.  Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[29]  Alina M. Chircu,et al.  IOT AND AI IN HEALTHCARE: A SYSTEMATIC LITERATURE REVIEW , 2018 .

[30]  Melissa E. Hogg,et al.  Evolution of a Novel Robotic Training Curriculum in a Complex General Surgical Oncology Fellowship , 2018, Annals of Surgical Oncology.

[31]  A. Heriot,et al.  Utilising taTME and robotics to reduce R1 risk in locally advanced rectal cancer with rectovaginal and cervical involvement , 2019, Techniques in Coloproctology.

[32]  T. Sammour,et al.  Radiomics for Diagnosing Lateral Pelvic Lymph Nodes in Rectal Cancer: Artificial Intelligence Enabling Precision Medicine? , 2020, Annals of Surgical Oncology.

[33]  Yang Lei,et al.  Dose evaluation of MRI-based synthetic CT generated using a machine learning method for prostate cancer radiotherapy. , 2019, Medical dosimetry : official journal of the American Association of Medical Dosimetrists.

[34]  Thomas Blaschke,et al.  The rise of deep learning in drug discovery. , 2018, Drug discovery today.

[35]  Delaram Kahrobaei,et al.  Fully Automated Spleen Localization And Segmentation Using Machine Learning And 3D Active Contours , 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[36]  E. Haglind,et al.  Health Economic Analysis of Open and Robot-assisted Laparoscopic Surgery for Prostate Cancer Within the Prospective Multicentre LAPPRO Trial. , 2018, European urology.

[37]  S Vinitha Sree,et al.  Evolutionary algorithm-based classifier parameter tuning for automatic ovarian cancer tissue characterization and classification. , 2014, Ultraschall in der Medizin.

[38]  Manhua Liu,et al.  A multi-model deep convolutional neural network for automatic hippocampus segmentation and classification in Alzheimer’s disease , 2019, NeuroImage.

[39]  Eui Jin Hwang,et al.  Development and Validation of Deep Learning-based Automatic Detection Algorithm for Malignant Pulmonary Nodules on Chest Radiographs. , 2019, Radiology.

[40]  Geoffrey E. Hinton,et al.  Dynamic Routing Between Capsules , 2017, NIPS.

[41]  Ronald M. Summers,et al.  Vertebral Body Compression Fractures and Bone Density: Automated Detection and Classification on CT Images. , 2017, Radiology.

[42]  Richard F. Macko,et al.  Task-specific ankle robotics gait training after stroke: a randomized pilot study , 2016, Journal of NeuroEngineering and Rehabilitation.

[43]  R. Ward,et al.  The role of substance use and emotion dysregulation in predicting risk for incapacitated sexual revictimization in women: results of a prospective investigation. , 2013, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[44]  Gianpaolo Francesco Trotta,et al.  A performance comparison between shallow and deeper neural networks supervised classification of tomosynthesis breast lesions images , 2019, Cognitive Systems Research.

[45]  T. Luukkaala,et al.  Implementing robotic surgery to gynecologic oncology: the first 300 operations performed at a tertiary hospital , 2015, Acta obstetricia et gynecologica Scandinavica.

[46]  Tianjiang Hu,et al.  Biorobotics with Hybrid and Multimodal Locomotion [TC Spotlight] , 2015, IEEE Robotics Autom. Mag..

[47]  D Stoyanov,et al.  Robotics, artificial intelligence and distributed ledgers in surgery: data is key! , 2018, Techniques in Coloproctology.

[48]  J. Suri,et al.  A Novel Block Imaging Technique Using Nine Artificial Intelligence Models for COVID-19 Disease Classification, Characterization and Severity Measurement in Lung Computed Tomography Scans on an Italian Cohort , 2021, Journal of Medical Systems.

[49]  Eui Jin Hwang,et al.  Development and Validation of a Deep Learning–based Automatic Detection Algorithm for Active Pulmonary Tuberculosis on Chest Radiographs , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[50]  Anselmo Cardoso de Paiva,et al.  Computer-aided diagnosis system for lung nodules based on computed tomography using shape analysis, a genetic algorithm, and SVM , 2016, Medical & Biological Engineering & Computing.

[51]  Quanzheng Li,et al.  Artificial intelligence matches subjective severity assessment of pneumonia for prediction of patient outcome and need for mechanical ventilation: a cohort study , 2021, Scientific reports.

[52]  Wei Zhang,et al.  Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study , 2020, Nature Communications.

[53]  O. P. Yadav,et al.  Pearl millet genome sequence provides a resource to improve agronomic traits in arid environments , 2017, Nature Biotechnology.

[54]  K. Tieu,et al.  The contemporary role of robotics in surgery: A predictive mathematical model on the short-term effectiveness of robotic and laparoscopic surgery , 2019, Laparoscopic, Endoscopic and Robotic Surgery.

[55]  F. Collins,et al.  A new initiative on precision medicine. , 2015, The New England journal of medicine.

[56]  Mohsen Guizani,et al.  Deep Feature Learning for Medical Image Analysis with Convolutional Autoencoder Neural Network , 2017, IEEE Transactions on Big Data.

[57]  Kilian Q. Weinberger,et al.  Densely Connected Convolutional Networks , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[58]  Diane J. Cook,et al.  Robot-enabled support of daily activities in smart home environments , 2019, Cognitive Systems Research.

[59]  C. D'Orsi,et al.  Effectiveness of computer-aided detection in community mammography practice. , 2011, Journal of the National Cancer Institute.

[60]  A. Madabhushi,et al.  Radiomic features for prostate cancer detection on MRI differ between the transition and peripheral zones: Preliminary findings from a multi‐institutional study , 2017, Journal of magnetic resonance imaging : JMRI.

[61]  Daniel G. Anderson,et al.  Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning , 2019, Proceedings of the National Academy of Sciences.

[62]  Nazar Zaki,et al.  Applying the Inverse Efficiency Score to Visual–Motor Task for Studying Speed-Accuracy Performance While Aging , 2020, Frontiers in Aging Neuroscience.

[63]  Joel J. P. C. Rodrigues,et al.  A novel deep learning based framework for the detection and classification of breast cancer using transfer learning , 2019, Pattern Recognit. Lett..

[64]  Robin R. Murphy,et al.  Introduction to AI Robotics , 2000 .

[65]  D. Aust,et al.  Staging of rectal cancer: diagnostic potential of multiplanar reconstructions with MDCT. , 2004, AJR. American journal of roentgenology.

[66]  E. Friedman,et al.  The Microbiome-Host Interaction as a Potential Driver of Anastomotic Leak , 2019, Current Gastroenterology Reports.

[67]  Mary E. Haas,et al.  Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations , 2018, Nature Genetics.

[68]  Hiba Chougrad,et al.  Deep Convolutional Neural Networks for breast cancer screening , 2018, Comput. Methods Programs Biomed..

[69]  Jeong Hyun Lee,et al.  A Computer-Aided Diagnosis System Using Artificial Intelligence for the Diagnosis and Characterization of Thyroid Nodules on Ultrasound: Initial Clinical Assessment. , 2017, Thyroid : official journal of the American Thyroid Association.

[70]  Agata Rozga,et al.  Artificial Intelligence and Robotics: A Nurse Leader's Primer , 2018, Nurse Leader.

[71]  Paul Babyn,et al.  Generative Adversarial Network in Medical Imaging: A Review , 2018, Medical Image Anal..

[72]  N. Arunkumar,et al.  An IoMT cloud-based real time sleep apnea detection scheme by using the SpO2 estimation supported by heart rate variability , 2019, Future Gener. Comput. Syst..

[73]  Bram van Ginneken,et al.  COVID-19 on Chest Radiographs: A Multireader Evaluation of an Artificial Intelligence System , 2020, Radiology.

[74]  F. Pfeiffer,et al.  Efficient Deep Network Architectures for Fast Chest X-Ray Tuberculosis Screening and Visualization , 2019, Scientific Reports.

[75]  Tae-Seong Kim,et al.  A fully integrated computer-aided diagnosis system for digital X-ray mammograms via deep learning detection, segmentation, and classification , 2018, Int. J. Medical Informatics.

[76]  Wei-Hua Hu,et al.  Structural Health Monitoring of a Prestressed Concrete Bridge Based on Statistical Pattern Recognition of Continuous Dynamic Measurements over 14 years , 2018, Sensors.

[77]  G. Gautam,et al.  Robotics in urologic oncology , 2015, Journal of minimal access surgery.

[78]  Jaime S. Cardoso,et al.  INbreast: toward a full-field digital mammographic database. , 2012, Academic radiology.

[79]  Yu Cao,et al.  Medical sieve: a cognitive assistant for radiologists and cardiologists , 2016, SPIE Medical Imaging.

[80]  Inkyung Jung,et al.  Deep Learning Algorithms with Demographic Information Help to Detect Tuberculosis in Chest Radiographs in Annual Workers’ Health Examination Data , 2019, International journal of environmental research and public health.

[81]  A. Gamian,et al.  The melibiose-derived glycation product mimics a unique epitope present in human and animal tissues , 2021, Scientific Reports.

[82]  Gaurav Pandey,et al.  Objective risk stratification of prostate cancer using machine learning and radiomics applied to multiparametric magnetic resonance images , 2019, Scientific Reports.

[83]  Frank Gaillard,et al.  Computer vs human: Deep learning versus perceptual training for the detection of neck of femur fractures , 2019, Journal of medical imaging and radiation oncology.

[84]  Yoshua Bengio,et al.  Generative Adversarial Nets , 2014, NIPS.

[85]  June-Goo Lee,et al.  Deep Learning in Medical Imaging: General Overview , 2017, Korean journal of radiology.

[86]  Zhiguo Zhou,et al.  Attention Guided Lymph Node Malignancy Prediction in Head and Neck Cancer. , 2021, International journal of radiation oncology, biology, physics.

[87]  Andre Esteva,et al.  A guide to deep learning in healthcare , 2019, Nature Medicine.

[88]  R. Thornhill,et al.  Transition zone prostate cancer: Logistic regression and machine‐learning models of quantitative ADC, shape and texture features are highly accurate for diagnosis , 2019, Journal of magnetic resonance imaging : JMRI.

[89]  Robin Coope,et al.  Rise of the Machines: Advances in Deep Learning for Cancer Diagnosis. , 2019, Trends in cancer.

[90]  Lipo Wang,et al.  Deep Learning Applications in Medical Image Analysis , 2018, IEEE Access.

[91]  Konstantinos N. Plataniotis,et al.  Brain Tumor Type Classification via Capsule Networks , 2018, 2018 25th IEEE International Conference on Image Processing (ICIP).

[92]  M. Baxter,et al.  Delay discounting decisions are linked to temporal distance representations of world events across cultures , 2020, Scientific Reports.

[93]  Ronald M. Summers,et al.  Identification of muscle and subcutaneous and intermuscular adipose tissue on thigh MRI of muscular dystrophy , 2016, 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI).

[94]  Woo Kyung Moon,et al.  Breast cancer detected with screening US: reasons for nondetection at mammography. , 2014, Radiology.

[95]  Jing Li,et al.  SD-CNN: a Shallow-Deep CNN for Improved Breast Cancer Diagnosis , 2018, Comput. Medical Imaging Graph..

[96]  Bram van Ginneken,et al.  A survey on deep learning in medical image analysis , 2017, Medical Image Anal..

[97]  Shuoyu Wang,et al.  A New Directional-Intent Recognition Method for Walking Training Using an Omnidirectional Robot , 2017, J. Intell. Robotic Syst..

[98]  Nikolas Lessmann,et al.  Automated Assessment of CO-RADS and Chest CT Severity Scores in Patients with Suspected COVID-19 Using Artificial Intelligence , 2020, Radiology.

[99]  Li Ding,et al.  Germline Mutations in Predisposition Genes in Pediatric Cancer. , 2015, The New England journal of medicine.

[100]  Kenji Suzuki,et al.  Overview of deep learning in medical imaging , 2017, Radiological Physics and Technology.

[101]  U. Rajendra Acharya,et al.  Evolutionary algorithm based classifier parameter tuning for automatic diabetic retinopathy grading: A hybrid feature extraction approach , 2013, Knowl. Based Syst..

[102]  Maryellen L. Giger,et al.  A deep learning methodology for improved breast cancer diagnosis using multiparametric MRI , 2020, Scientific Reports.

[103]  Yun Lu,et al.  Artificial intelligence system of faster region-based convolutional neural network surpassing senior radiologists in evaluation of metastatic lymph nodes of rectal cancer , 2019, Chinese medical journal.

[104]  Daniel L Rubin,et al.  A curated mammography data set for use in computer-aided detection and diagnosis research , 2017, Scientific Data.

[105]  Ross B. Girshick,et al.  Fast R-CNN , 2015, 1504.08083.

[106]  S. Ciatto,et al.  Comparison of standard reading and computer aided detection (CAD) on a national proficiency test of screening mammography. , 2003, European journal of radiology.

[107]  Kai Zhang,et al.  Deep learning for image-based cancer detection and diagnosis - A survey , 2018, Pattern Recognit..

[108]  Irena Papadopoulos,et al.  Views of nurses and other health and social care workers on the use of assistive humanoid and animal-like robots in health and social care: a scoping review , 2018, Contemporary nurse.

[109]  Z. Tian,et al.  Concordance Study Between IBM Watson for Oncology and Clinical Practice for Patients with Cancer in China. , 2018, The oncologist.

[110]  Fatma Taher,et al.  A Deep Learning-Based Approach for the Detection and Localization of Prostate Cancer in T2 Magnetic Resonance Images , 2018, Journal of Digital Imaging.

[111]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.

[112]  Marcella Q. Salomão,et al.  Unique corneal tomography features of allergic eye disease identified by OCT imaging and artificial intelligence , 2020, Journal of biophotonics.

[113]  Bertalan Meskó,et al.  The role of artificial intelligence in precision medicine , 2017 .

[114]  R. van Hillegersberg,et al.  Surgical robotics for esophageal cancer , 2018, Annals of the New York Academy of Sciences.

[115]  Yasuhisa Hirata,et al.  Ethically Aligned Design for Assistive Robotics , 2018, 2018 IEEE International Conference on Intelligence and Safety for Robotics (ISR).

[116]  Joel W. Burdick,et al.  Human motion analysis in medical robotics via high-dimensional inverse reinforcement learning , 2020, Int. J. Robotics Res..

[117]  S. Astley,et al.  Single reading with computer-aided detection for screening mammography. , 2008, The New England journal of medicine.

[118]  Muhammad Zeeshan,et al.  Diagnostic Accuracy of Digital Mammography in the Detection of Breast Cancer , 2018, Cureus.

[119]  C. Gastmans,et al.  The use of care robots in aged care: A systematic review of argument-based ethics literature. , 2018, Archives of gerontology and geriatrics.

[120]  A. Tsung,et al.  ASO Author Reflections: The Evolution of Minimally Invasive Liver Surgery and the Future with Robotics , 2018, Annals of Surgical Oncology.

[121]  Edwin Valarezo,et al.  Simultaneous Detection and Classification of Breast Masses in Digital Mammograms via a Deep Learning YOLO-based CAD System , 2018, Comput. Methods Programs Biomed..

[122]  Sasank Chilamkurthy,et al.  Deep learning algorithms for detection of critical findings in head CT scans: a retrospective study , 2018, The Lancet.

[123]  Eugenio Culurciello,et al.  An Analysis of Deep Neural Network Models for Practical Applications , 2016, ArXiv.

[124]  Sameer Antani,et al.  Spatiotemporal feature extraction and classification of Alzheimer’s disease using deep learning 3D-CNN for fMRI data , 2020, Journal of medical imaging.

[125]  Kathryn D Bungartz,et al.  Making the right calls in precision oncology , 2018, Nature Biotechnology.

[126]  Ronald M. Summers,et al.  Sclerotic rib metastases detection on routine CT images , 2012, 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI).

[127]  Kimmo Kartasalo,et al.  Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study. , 2020, The Lancet. Oncology.

[128]  S. Lau,et al.  Outside the operating room: How a robotics program changed resource utilization on the inpatient Ward. , 2017, Gynecologic oncology.

[129]  Xinyu Jin,et al.  CT Images Recognition of Pulmonary Tuberculosis Based on Improved Faster RCNN and U-Net , 2019, 2019 10th International Conference on Information Technology in Medicine and Education (ITME).

[130]  Stefano Pedemonte,et al.  DeepSPINE: Automated Lumbar Vertebral Segmentation, Disc-level Designation, and Spinal Stenosis Grading Using Deep Learning , 2018, ArXiv.

[131]  Kaiming He,et al.  Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks , 2015, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[132]  P. Pickhardt,et al.  MRI-Based Machine Learning for Differentiating Borderline From Malignant Epithelial Ovarian Tumors: A Multicenter Study. , 2020, Journal of magnetic resonance imaging : JMRI.

[133]  A. Chinnaiyan,et al.  Precision medicine in pediatric oncology: Lessons learned and next steps , 2017, Pediatric blood & cancer.

[134]  Yang Yang,et al.  Radiomic analysis using contrast-enhanced CT: predict treatment response to pulsed low dose rate radiotherapy in gastric carcinoma with abdominal cavity metastasis. , 2018, Quantitative imaging in medicine and surgery.

[135]  C. Krittanawong,et al.  Artificial Intelligence in Precision Cardiovascular Medicine. , 2017, Journal of the American College of Cardiology.

[136]  Alessandro Saffiotti,et al.  A Cloud Robotics Solution to Improve Social Assistive Robots for Active and Healthy Aging , 2016, Int. J. Soc. Robotics.

[137]  Nobuhiko Hata,et al.  Robotics in MRI-Guided Interventions , 2018, Topics in magnetic resonance imaging : TMRI.

[138]  N. Stevens,et al.  Lack of Rule-Adherence During Mountain Gorilla Tourism Encounters in Bwindi Impenetrable National Park, Uganda, Places Gorillas at Risk From Human Disease , 2020, Frontiers in Public Health.

[139]  Cheng Chen,et al.  Artificial Intelligence Applied to Osteoporosis: A Performance Comparison of Machine Learning Algorithms in Predicting Fragility Fractures From MRI Data , 2018, Journal of magnetic resonance imaging : JMRI.

[140]  Bulat Ibragimov,et al.  Prostate cancer classification with multiparametric MRI transfer learning model , 2019, Medical physics.

[141]  Josien P. W. Pluim,et al.  Not‐so‐supervised: A survey of semi‐supervised, multi‐instance, and transfer learning in medical image analysis , 2018, Medical Image Anal..

[142]  B. Rost,et al.  Protein function in precision medicine: deep understanding with machine learning , 2016, FEBS letters.

[143]  Shinil K. Shah,et al.  The Current Role of Robotics in Colorectal Surgery , 2019, Current Gastroenterology Reports.

[144]  Yuanyuan Wang,et al.  Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer , 2020, Nature Communications.

[145]  Bumshik Lee,et al.  Using Deep CNN with Data Permutation Scheme for Classification of Alzheimer's Disease in Structural Magnetic Resonance Imaging (sMRI) , 2019, IEICE Trans. Inf. Syst..

[146]  Arturo Brunetti,et al.  Detection of Extraprostatic Extension of Cancer on Biparametric MRI Combining Texture Analysis and Machine Learning: Preliminary Results. , 2019, Academic radiology.

[147]  Aydin Kaya,et al.  Cascaded classifiers and stacking methods for classification of pulmonary nodule characteristics , 2018, Comput. Methods Programs Biomed..

[148]  E. D. Leonardo,et al.  Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice , 2019, Scientific Reports.

[149]  Daniel Forsberg,et al.  Detection and Labeling of Vertebrae in MR Images Using Deep Learning with Clinical Annotations as Training Data , 2017, Journal of Digital Imaging.

[150]  S. Ramalingam,et al.  Tumor Mutation Burden: Leading Immunotherapy to the Era of Precision Medicine? , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[151]  Ronald M. Summers,et al.  Computer-aided diagnosis prior to conventional interpretation of prostate mpMRI: an international multi-reader study , 2018, European Radiology.

[152]  K. Cao,et al.  Using Artificial Intelligence to Detect COVID-19 and Community-acquired Pneumonia Based on Pulmonary CT: Evaluation of the Diagnostic Accuracy , 2020 .

[153]  Ming Yang,et al.  Author Correction: Three-Category Classification of Magnetic Resonance Hearing Loss Images Based on Deep Autoencoder , 2017, Journal of Medical Systems.

[154]  Stefano Pedemonte,et al.  DeepSPINE: Automated Lumbar Vertebral Segmentation, Disc-level Designation, and Spinal Stenosis Grading Using Deep Learning , 2018, MLHC.

[155]  Antonio Greco,et al.  Assistive Robots for the Elderly: Innovative Tools to Gather Health Relevant Data , 2019, Data Science for Healthcare.

[156]  Brian S. Parsley Robotics in Orthopedics: A Brave New World. , 2018, The Journal of arthroplasty.

[157]  Li Li,et al.  Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records , 2016, Scientific Reports.

[158]  Li Liu,et al.  Breast mass classification via deeply integrating the contextual information from multi-view data , 2018, Pattern Recognit..

[159]  Lianfang Tian,et al.  Automatic benign and malignant classification of pulmonary nodules in thoracic computed tomography based on RF algorithm , 2018, IET Image Process..

[160]  Ali Kashif Bashir,et al.  Pulmonary Nodule Classification Based on Heterogeneous Features Learning , 2021, IEEE Journal on Selected Areas in Communications.

[161]  Alfonso Reginelli,et al.  Artificial intelligence to codify lung CT in Covid-19 patients , 2020, La radiologia medica.

[162]  G. Pazour,et al.  Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness , 2017, Scientific Reports.

[163]  S. Stables,et al.  Identifying Fatal Head Injuries on Postmortem Computed Tomography Using Convolutional Neural Network/Deep Learning: A Feasibility Study , 2020, Journal of forensic sciences.

[164]  Jian Sun,et al.  Deep Residual Learning for Image Recognition , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[165]  István Csabai,et al.  Detecting and classifying lesions in mammograms with Deep Learning , 2017, Scientific Reports.

[166]  Muhammad Nadeem Majeed,et al.  Multi-class Alzheimer's disease classification using image and clinical features , 2018, Biomed. Signal Process. Control..

[167]  Ali Farhadi,et al.  YOLOv3: An Incremental Improvement , 2018, ArXiv.

[168]  Tao Liu,et al.  Searching for prostate cancer by fully automated magnetic resonance imaging classification: deep learning versus non-deep learning , 2017, Scientific Reports.

[169]  Sandeep Kumar Polu IoMT Based Smart Health Care Monitoring System , 2019 .

[170]  Darwin G. Caldwell,et al.  Reinforcement Learning in Robotics: Applications and Real-World Challenges , 2013, Robotics.

[171]  Fatma Latifoğlu,et al.  Analysis of Consciousness Level Using Galvanic Skin Response during Therapeutic Effect , 2020, Journal of Medical Systems.

[172]  Liang Zhang,et al.  Definition and application of precision medicine , 2016, Chinese journal of traumatology = Zhonghua chuang shang za zhi.

[173]  Kayvan Najarian,et al.  Fracture Detection in Traumatic Pelvic CT Images , 2012, Int. J. Biomed. Imaging.

[174]  Ghassan Hamarneh,et al.  Generative adversarial networks to segment skin lesions , 2018, 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018).

[175]  Y Ramya,et al.  Abstract S6-07: Double blinded validation study to assess performance of IBM artificial intelligence platform, Watson for oncology in comparison with Manipal multidisciplinary tumour board – First study of 638 breast cancer cases , 2017 .

[176]  Holden H. Wu,et al.  Deep transfer learning-based prostate cancer classification using 3 Tesla multi-parametric MRI , 2018, Abdominal Radiology.

[177]  Jing Wang,et al.  Machine learning-based analysis of MR radiomics can help to improve the diagnostic performance of PI-RADS v2 in clinically relevant prostate cancer , 2017, European Radiology.

[178]  Anselmo Cardoso de Paiva,et al.  Classification of malignant and benign lung nodules using taxonomic diversity index and phylogenetic distance , 2018, Medical & Biological Engineering & Computing.

[179]  Ian Loram,et al.  Objective Analysis of Neck Muscle Boundaries for Cervical Dystonia Using Ultrasound Imaging and Deep Learning , 2020, IEEE Journal of Biomedical and Health Informatics.

[180]  Joseph E. Burns,et al.  Mixed spine metastasis detection through positron emission tomography/computed tomography synthesis and multiclassifier , 2017, Journal of medical imaging.

[181]  Davide Fontanarosa,et al.  Ultrasound guidance in minimally invasive robotic procedures☆ , 2019, Medical Image Anal..

[182]  Gustavo Carneiro,et al.  A deep learning approach for the analysis of masses in mammograms with minimal user intervention , 2017, Medical Image Anal..

[183]  Guy Hoffman,et al.  Home robotic devices for older adults: Opportunities and concerns , 2019, Comput. Hum. Behav..

[184]  Vijay Kumar Chattu,et al.  Designing Futuristic Telemedicine Using Artificial Intelligence and Robotics in the COVID-19 Era , 2020, Frontiers in Public Health.

[185]  Shuang Zheng,et al.  Automated and accurate quantification of subcutaneous and visceral adipose tissue from magnetic resonance imaging based on machine learning. , 2019, Magnetic resonance imaging.

[186]  Alessandro Saffiotti,et al.  Towards a science of integrated AI and Robotics , 2017, Artif. Intell..

[187]  M. Weiser,et al.  Does gadolinium-based contrast material improve diagnostic accuracy of local invasion in rectal cancer MRI? A multireader study. , 2015, AJR. American journal of roentgenology.

[188]  Kok-Swee Sim,et al.  Convolutional neural network improvement for breast cancer classification , 2019, Expert Syst. Appl..

[189]  K. Mori,et al.  Fully automated diagnostic system with artificial intelligence using endocytoscopy to identify the presence of histologic inflammation associated with ulcerative colitis (with video). , 2019, Gastrointestinal endoscopy.