RAS oncogenes: weaving a tumorigenic web

[1]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[2]  H. Coller,et al.  Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. , 2011, Genes & development.

[3]  T. Jacks,et al.  Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. , 2011, Blood.

[4]  G. Yoon,et al.  Involvement of Autophagy in Oncogenic K-Ras-induced Malignant Cell Transformation , 2011, The Journal of Biological Chemistry.

[5]  T. Jacks,et al.  Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. , 2011, Cancer cell.

[6]  C. Kenific,et al.  Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation , 2011, Molecular biology of the cell.

[7]  Paul Martin,et al.  Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation , 2010, PLoS biology.

[8]  T. H. van der Kwast,et al.  FGFR3, HRAS, KRAS, NRAS and PIK3CA Mutations in Bladder Cancer and Their Potential as Biomarkers for Surveillance and Therapy , 2010, PloS one.

[9]  A. Bardelli,et al.  Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. , 2010, JAMA.

[10]  A. Guha,et al.  Immune infiltration of spontaneous mouse astrocytomas is dominated by immunosuppressive cells from early stages of tumor development. , 2010, Cancer research.

[11]  I. Huijbers,et al.  Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice. , 2010, Cancer research.

[12]  M. Crow,et al.  Induction of the Apoptosis Inhibitor ARC by Ras in Human Cancers* , 2010, The Journal of Biological Chemistry.

[13]  Kathryn G. Foster,et al.  Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony* , 2010, The Journal of Biological Chemistry.

[14]  C. Mattos,et al.  Allosteric modulation of Ras positions Q61 for a direct role in catalysis , 2010, Proceedings of the National Academy of Sciences.

[15]  C. Hill,et al.  Smad3 Protein Levels Are Modulated by Ras Activity and during the Cell Cycle to Dictate Transforming Growth Factor-β Responses* , 2009, The Journal of Biological Chemistry.

[16]  G. Pfeifer,et al.  The RASSF proteins in cancer; from epigenetic silencing to functional characterization. , 2009, Biochimica et biophysica acta.

[17]  A. Poustka,et al.  Down‐regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells , 2009, International journal of cancer.

[18]  R. Hruban,et al.  Widespread Activation of the DNA Damage Response in Human Pancreatic Intraepithelial Neoplasia , 2009, Modern Pathology.

[19]  R. Vonderheide,et al.  Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer. , 2009, Cancer letters.

[20]  A. Yalçin,et al.  Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer. , 2009, Experimental and molecular pathology.

[21]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[22]  S. Steinberg,et al.  A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis , 2009, PloS one.

[23]  G. Merlino,et al.  Uncoupling of the LKB1-AMPKα Energy Sensor Pathway by Growth Factors and Oncogenic BRAFV600E , 2009, PloS one.

[24]  Russell G. Jones,et al.  Tumor suppressors and cell metabolism: a recipe for cancer growth. , 2009, Genes & development.

[25]  R. Levine,et al.  High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. , 2009, Blood.

[26]  Takeshi Imamura,et al.  Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β* , 2009, Journal of Biological Chemistry.

[27]  Yoav I. Henis,et al.  Ras acylation, compartmentalization and signaling nanoclusters (Review) , 2009, Molecular membrane biology.

[28]  L. Senelick It (review) , 2008 .

[29]  K. Rauen,et al.  Noonan, Costello and cardio–facio–cutaneous syndromes: dysregulation of the Ras–MAPK pathway , 2008, Expert Reviews in Molecular Medicine.

[30]  Allan Balmain,et al.  Kras regulatory elements and exon 4A determine mutation specificity in lung cancer , 2008, Nature Genetics.

[31]  M. Borrello,et al.  Inflammation and cancer: the oncogene-driven connection. , 2008, Cancer letters.

[32]  D. Saur,et al.  A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors , 2008, Proceedings of the National Academy of Sciences.

[33]  Robert A. Weinberg,et al.  Ras oncogenes: split personalities , 2008, Nature Reviews Molecular Cell Biology.

[34]  M. Ladanyi,et al.  Frequency and Distinctive Spectrum of KRAS Mutations in Never Smokers with Lung Adenocarcinoma , 2008, Clinical Cancer Research.

[35]  D. Radisky,et al.  Mechanisms of Disease: epithelial–mesenchymal transition—does cellular plasticity fuel neoplastic progression? , 2008, Nature Clinical Practice Oncology.

[36]  A. Sweet-Cordero,et al.  Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon , 2008, Nature Genetics.

[37]  S. Patra Ras regulation of DNA-methylation and cancer. , 2008, Experimental cell research.

[38]  Jiri Bartek,et al.  An Oncogene-Induced DNA Damage Model for Cancer Development , 2008, Science.

[39]  B. Ancrile,et al.  Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics. , 2008, Molecular interventions.

[40]  J. Pouysségur,et al.  Hypoxia and cancer , 2007, Journal of Molecular Medicine.

[41]  Michael R. Green,et al.  An elaborate pathway required for Ras-mediated epigenetic silencing , 2007, Nature.

[42]  D. Tuveson,et al.  Dynamics of the immune reaction to pancreatic cancer from inception to invasion. , 2007, Cancer research.

[43]  C. Cordon-Cardo,et al.  Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis. , 2007, The Journal of clinical investigation.

[44]  R. Shaw,et al.  Glucose metabolism and cancer. , 2006, Current opinion in cell biology.

[45]  Aaron Bensimon,et al.  Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication , 2006, Nature.

[46]  L. Alberghina,et al.  Ras-dependent carbon metabolism and transformation in mouse fibroblasts , 2006, Oncogene.

[47]  P. Bastiaens,et al.  Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors. , 2006, Current opinion in cell biology.

[48]  Sarah Edkins,et al.  Recurrent KRAS codon 146 mutations in human colorectal cancer , 2006, Cancer biology & therapy.

[49]  G. Tonon,et al.  K-ras activation generates an inflammatory response in lung tumors , 2006, Oncogene.

[50]  G. Babcock,et al.  Oncogenic RAS Induces Accelerated Transition through G2/M and Promotes Defects in the G2 DNA Damage and Mitotic Spindle Checkpoints* , 2006, Journal of Biological Chemistry.

[51]  C. Thompson,et al.  PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. , 2006, Molecular cell.

[52]  M. Pfreundschuh,et al.  Naturally occurring T-cell response against mutated p21 ras oncoprotein in pancreatic cancer. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

[53]  Kam Y. J. Zhang,et al.  Germline KRAS mutations cause Noonan syndrome , 2006, Nature Genetics.

[54]  G. Gores,et al.  Regulation of Apoptosis , 2005 .

[55]  I. B. Borel Rinkes,et al.  Control of colorectal metastasis formation by K-Ras. , 2005, Biochimica et biophysica acta.

[56]  H. Beug,et al.  Molecular requirements for epithelial-mesenchymal transition during tumor progression. , 2005, Current opinion in cell biology.

[57]  Xuedong Liu,et al.  Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling , 2005, Molecular and Cellular Biology.

[58]  R. Coffey,et al.  E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. , 2005, Surgery.

[59]  Marta Cascante,et al.  K-ras Codon-Specific Mutations Produce Distinctive Metabolic Phenotypes in Human Fibroblasts , 2005 .

[60]  C. Johannessen,et al.  The NF1 tumor suppressor critically regulates TSC2 and mTOR. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[61]  Carmine Vecchione,et al.  Replacement of K‐Ras with H‐Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice , 2005, EMBO reports.

[62]  Paul Tempst,et al.  Phosphorylation and Functional Inactivation of TSC2 by Erk Implications for Tuberous Sclerosisand Cancer Pathogenesis , 2005, Cell.

[63]  S. Schreiber,et al.  Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[64]  T. Ørntoft,et al.  DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis , 2005, Nature.

[65]  Dimitris Kletsas,et al.  Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions , 2005, Nature.

[66]  G. Pfeifer,et al.  The tumor suppressor RASSF1A in human carcinogenesis: an update. , 2005, Histology and histopathology.

[67]  K. Giehl Oncogenic Ras in tumour progression and metastasis , 2005, Biological chemistry.

[68]  W. Kolch,et al.  Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. , 2005, Cancer research.

[69]  N. Amariglio,et al.  Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. , 2005, Cancer research.

[70]  Steven P Gygi,et al.  Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[71]  J. S. Gutkind,et al.  Conditional Expression of K-ras in an Epithelial Compartment that Includes the Stem Cells Is Sufficient to Promote Squamous Cell Carcinogenesis , 2004, Cancer Research.

[72]  G. Sa,et al.  P27 expression is regulated by separate signaling pathways, downstream of Ras, in each cell cycle phase. , 2004, Experimental cell research.

[73]  Wenjun Guo,et al.  Integrin signalling during tumour progression , 2004, Nature Reviews Molecular Cell Biology.

[74]  Steven P Gygi,et al.  Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[75]  Tsuneyuki Oikawa,et al.  ETS transcription factors: Possible targets for cancer therapy , 2004, Cancer science.

[76]  N. Sonenberg,et al.  eIF4E – from translation to transformation , 2004, Oncogene.

[77]  R. DePinho,et al.  Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. , 2004, Cancer cell.

[78]  X. Shu,et al.  RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia , 2004, Leukemia.

[79]  P. M. Campbell,et al.  Oncogenic Ras and its role in tumor cell invasion and metastasis. , 2004, Seminars in cancer biology.

[80]  J. Rak,et al.  Oncogenes and tumor angiogenesis: the question of vascular "supply" and vascular "demand". , 2004, Seminars in cancer biology.

[81]  D. Bar-Sagi,et al.  Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. , 2004, Cancer cell.

[82]  E. Voest,et al.  Stimulation of angiogenesis by Ras proteins. , 2004, Biochimica et biophysica acta.

[83]  J. Kutok,et al.  Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. , 2004, The Journal of clinical investigation.

[84]  R. Perona,et al.  Control of oncogenesis and cancer therapy resistance , 2004, British Journal of Cancer.

[85]  M. Engelse,et al.  The fibrinolytic system and matrix metalloproteinases in angiogenesis and tumor progression. , 2004, Seminars in thrombosis and hemostasis.

[86]  T. Jacks,et al.  Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[87]  Channing J Der,et al.  The dark side of Ras: regulation of apoptosis , 2003, Oncogene.

[88]  E. Petricoin,et al.  Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.

[89]  H. Beug,et al.  Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis , 2003, Nature Reviews Molecular Cell Biology.

[90]  Manuel Serrano,et al.  Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. , 2003, Cancer cell.

[91]  L. Cantley,et al.  United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. , 2003, Biochemical Society transactions.

[92]  F. Brembeck,et al.  The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice. , 2003, Cancer research.

[93]  D. Bar-Sagi,et al.  Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. , 2003, Genes & development.

[94]  P. Carmeliet,et al.  uPAR: a versatile signalling orchestrator , 2002, Nature Reviews Molecular Cell Biology.

[95]  Seung-Ki Lee,et al.  Two transactivation domains of hypoxia-inducible factor-1alpha regulated by the MEK-1/p42/p44 MAPK pathway. , 2002, Molecules and cells.

[96]  A. Zeiher,et al.  Hypoxic Induction of the Hypoxia-Inducible Factor Is Mediated via the Adaptor Protein Shc in Endothelial Cells , 2002, Circulation research.

[97]  Richard A. Flavell,et al.  The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH2-Terminal Kinase , 2002, Molecular and Cellular Biology.

[98]  J. Pouysségur,et al.  Identification of Two Sp1 Phosphorylation Sites for p42/p44 Mitogen-activated Protein Kinases , 2002, The Journal of Biological Chemistry.

[99]  L. Norton,et al.  Cyclooxygenase-2 Is Overexpressed in HER-2/neu-positive Breast Cancer , 2002, The Journal of Biological Chemistry.

[100]  Yong Jiang,et al.  Regulation of matrix metalloproteinase-9 (MMP-9) by translational efficiency in murine prostate carcinoma cells. , 2002, Cancer research.

[101]  P. Khavari,et al.  Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation , 2002, Oncogene.

[102]  R. Xavier,et al.  Identification of a Novel Ras-Regulated Proapoptotic Pathway , 2002, Current Biology.

[103]  E. Sahai,et al.  RHO–GTPases and cancer , 2002, Nature Reviews Cancer.

[104]  J. Lawler,et al.  Thrombospondin‐1 as an endogenous inhibitor of angiogenesis and tumor growth , 2002, Journal of cellular and molecular medicine.

[105]  H. Varmus,et al.  Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. , 2001, Genes & development.

[106]  T. Jacks,et al.  Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. , 2001, Genes & development.

[107]  Saroj P. Mathupala,et al.  Glucose Catabolism in Cancer Cells , 2001, The Journal of Biological Chemistry.

[108]  A. Harris,et al.  Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. , 2001, Cancer research.

[109]  Kenneth M. Yamada,et al.  Fibronectin, integrins, and growth control , 2001, Journal of cellular physiology.

[110]  K. Akassoglou,et al.  Plasmin-dependent and -independent effects of plasminogen activators and inhibitor-1 on ex vivo angiogenesis. , 2001, American journal of physiology. Heart and circulatory physiology.

[111]  C. Rüegg,et al.  NSAIDs inhibit αVβ3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis , 2001, Nature Medicine.

[112]  M. Pepper Role of the Matrix Metalloproteinase and Plasminogen Activator-Plasmin Systems in Angiogenesis , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[113]  Y. Geng,et al.  Specific protection against breast cancers by cyclin D1 ablation , 2001, Nature.

[114]  H. Sheng,et al.  Transforming Growth Factor-β1 Promotes Invasiveness after Cellular Transformation with Activated Ras in Intestinal Epithelial Cells , 2001 .

[115]  J. Minna,et al.  Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. , 2001, Journal of the National Cancer Institute.

[116]  D. Woods,et al.  Induction of β3-Integrin Gene Expression by Sustained Activation of the Ras-Regulated Raf–MEK–Extracellular Signal-Regulated Kinase Signaling Pathway , 2001, Molecular and Cellular Biology.

[117]  T. Jacks,et al.  Somatic activation of the K-ras oncogene causes early onset lung cancer in mice , 2001, Nature.

[118]  A. Schulze,et al.  Analysis of the transcriptional program induced by Raf in epithelial cells , 2001, Nature Genetics.

[119]  F. Ismail-Beigi,et al.  Regulation of glut1 mRNA by Hypoxia-inducible Factor-1 , 2001, The Journal of Biological Chemistry.

[120]  D. Bar-Sagi A Ras by Any Other Name , 2001, Molecular and Cellular Biology.

[121]  A. Baldwin Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. , 2001, The Journal of clinical investigation.

[122]  C. Der,et al.  Ras Inactivation of the Retinoblastoma Pathway by Distinct Mechanisms in NIH 3T3 Fibroblast and RIE-1 Epithelial Cells* , 2000, The Journal of Biological Chemistry.

[123]  J. Nemunaitis,et al.  Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice , 2000, Gene Therapy.

[124]  J. Massagué,et al.  How cells read TGF-β signals , 2000, Nature Reviews Molecular Cell Biology.

[125]  C. Der,et al.  Dissection of Ras-Dependent Signaling Pathways Controlling Aggressive Tumor Growth of Human Fibrosarcoma Cells: Evidence for a Potential Novel Pathway , 2000, Molecular and Cellular Biology.

[126]  A. Bell,et al.  Ras Uses the Novel Tumor Suppressor RASSF1 as an Effector to Mediate Apoptosis* , 2000, The Journal of Biological Chemistry.

[127]  V. Braga,et al.  Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes. , 2000, Molecular biology of the cell.

[128]  Shigeyoshi Itohara,et al.  Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis , 2000, Nature Cell Biology.

[129]  Y. Oshika,et al.  Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line , 2000, British Journal of Cancer.

[130]  E. Thiel,et al.  Activated K‐ras is involved in regulation of integrin expression in human colon carcinoma cells , 2000, International journal of cancer.

[131]  Chun Xing Li,et al.  Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 , 2000, Nature Genetics.

[132]  John G. Collard,et al.  Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition , 2000, The Journal of cell biology.

[133]  B. Seliger,et al.  Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin , 2000, Bone Marrow Transplantation.

[134]  Eric C. Holland,et al.  Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice , 2000, Nature Genetics.

[135]  R. Kerbel,et al.  Activated ras Prevents Downregulation of Bcl-XL Triggered by Detachment from the Extracellular Matrix , 2000, The Journal of cell biology.

[136]  M. Mayo,et al.  The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. , 2000, Biochimica et biophysica acta.

[137]  S. Reddy,et al.  Transcriptional Regulation of the Cyclooxygenase-2 Gene in Activated Mast Cells* , 2000, The Journal of Biological Chemistry.

[138]  N. Ahn,et al.  Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. , 2000, Cancer Research.

[139]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[140]  G. Mills,et al.  Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway , 1999, Oncogene.

[141]  R. Goody,et al.  The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. , 1999, Structure.

[142]  J. Pouysségur,et al.  p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1* , 1999, The Journal of Biological Chemistry.

[143]  M. P. Quinlan Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation , 1999, Oncogene.

[144]  V. Rangnekar,et al.  Oncogenic Ras Sensitizes Cells to Apoptosis by Par-4* , 1999, The Journal of Biological Chemistry.

[145]  N. Arber Janus faces of ras: anti or pro-apoptotic? , 1999, Apoptosis.

[146]  C. Asselin,et al.  MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells. , 1999, American journal of physiology. Cell physiology.

[147]  C. Morelli,et al.  Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer. , 1999, Cancer Research.

[148]  D. Bar-Sagi,et al.  Suppression of Ras-Induced Apoptosis by the Rac GTPase , 1999, Molecular and Cellular Biology.

[149]  J. Downward,et al.  Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression* , 1999, The Journal of Biological Chemistry.

[150]  L. Chin,et al.  Essential role for oncogenic Ras in tumour maintenance , 1999, Nature.

[151]  J. Massagué,et al.  A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. , 1999, Genes & development.

[152]  J. Tschopp,et al.  Oncogenic Ras inhibits Fas ligand‐mediated apoptosis by downregulating the expression of Fas , 1999, The EMBO journal.

[153]  S Weijzen,et al.  Modulation of the immune response and tumor growth by activated Ras , 1999, Leukemia.

[154]  F. Al-Mulla,et al.  Structural differences between valine‐12 and aspartate‐12 Ras proteins may modify carcinoma aggression , 1999, The Journal of pathology.

[155]  R. Wolthuis,et al.  Ras caught in another affair: the exchange factors for Ral. , 1999, Current opinion in genetics & development.

[156]  G. Semenza,et al.  Oncogenic alterations of metabolism. , 1999, Trends in biochemical sciences.

[157]  J. Merchant,et al.  Sp1 phosphorylation by Erk 2 stimulates DNA binding. , 1999, Biochemical and biophysical research communications.

[158]  M. J. Newman,et al.  Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells , 1998, Current Biology.

[159]  H. Beug,et al.  TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis , 1998, Current Biology.

[160]  M. Roussel,et al.  Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. , 1998, Genes & development.

[161]  P. Carmeliet,et al.  Development and disease in proteinase-deficient mice: role of the plasminogen, matrix metalloproteinase and coagulation system. , 1998, Thrombosis research.

[162]  L. Pleyer,et al.  Regulation of apoptosis , 2007 .

[163]  R. Tennant,et al.  Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. , 1998, Genes & development.

[164]  M. Malumbres,et al.  RAS pathways to cell cycle control and cell transformation. , 1998, Frontiers in bioscience : a journal and virtual library.

[165]  R. DuBois,et al.  Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells , 1998, Cell.

[166]  J. Pouysségur,et al.  p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts* , 1998, The Journal of Biological Chemistry.

[167]  M. Mann,et al.  Cell cycle progression: new therapeutic target for vascular proliferative disease. , 1998, Circulation.

[168]  G. Gaudernack,et al.  Mutated Ras Peptides as Vaccines in Immunotherapy of Cancer , 1998, Vox sanguinis.

[169]  R. DuBois,et al.  Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells , 1998, Cell.

[170]  A. Norman,et al.  Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. , 1998, Journal of the National Cancer Institute.

[171]  Robert Tampé,et al.  Down‐regulation of the MHC class I antigen‐processing machinery after oncogenic transformation of murine fibroblasts , 1998, European journal of immunology.

[172]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[173]  C. Der,et al.  Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation* , 1997, The Journal of Biological Chemistry.

[174]  S. Oldham,et al.  A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells* , 1997, The Journal of Biological Chemistry.

[175]  W. Kabsch,et al.  The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. , 1997, Science.

[176]  Joseph R. Nevins,et al.  Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F , 1997, Nature.

[177]  M. Urich,et al.  A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation , 1997, Oncogene.

[178]  C. Der,et al.  Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways , 1997, Molecular and cellular biology.

[179]  L. Tentori,et al.  Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene. , 1997, Journal of experimental & clinical cancer research : CR.

[180]  N. Denko,et al.  Expression ofRap 1 suppresses genomic instability ofH-ras transformed mouse fibroblasts , 1997, Somatic cell and molecular genetics.

[181]  G. Evan,et al.  Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB , 1997, Nature.

[182]  H. Herschman,et al.  Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum* , 1996, The Journal of Biological Chemistry.

[183]  V. Ferrans,et al.  rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation , 1996, Molecular and cellular biology.

[184]  B. Seliger,et al.  Suppression of MHC class I antigens in oncogenic transformants: association with decreased recognition by cytotoxic T lymphocytes. , 1996, Experimental hematology.

[185]  D. Rifkin,et al.  Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals. , 1996, Cancer research.

[186]  E. Lengyel,et al.  Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences (*) , 1996, The Journal of Biological Chemistry.

[187]  B. Seliger,et al.  Multiple Levels of MHC Class I Down‐Regulation by ras Oncogenes , 1996, Scandinavian journal of immunology.

[188]  A. De Benedetti,et al.  Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: Implications for tumor angiogenesis , 1996, International journal of cancer.

[189]  J. Siegfried,et al.  Detection of K-ras mutations in lung carcinomas: relationship to prognosis. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[190]  Y. Wang,et al.  Regulation of the cell cycle machinery by oncogenic ras. , 1996, Oncogene.

[191]  J. Zhao,et al.  Regulation of Transforming Growth Factor β Receptors in H-ras Oncogene-transformed Rat Intestinal Epithelial Cells , 1995 .

[192]  O. Volpert,et al.  Inhibition of angiogenesis by thrombospondin-2. , 1995, Biochemical and biophysical research communications.

[193]  R. Kerbel,et al.  Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. , 1995, Cancer research.

[194]  C. Albanese,et al.  Transforming p21ras Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions (*) , 1995, The Journal of Biological Chemistry.

[195]  E. Lengyel,et al.  Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras(*) , 1995, The Journal of Biological Chemistry.

[196]  J. Abraham,et al.  Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. , 1995, Genes & development.

[197]  D. Byrd,et al.  CD4+ T-cell immunity to mutated ras protein in pancreatic and colon cancer patients. , 1995, Cancer research.

[198]  J. Stringer,et al.  Mitotic and post mitotic consequences of genomic instability induced by oncogenic Ha-Ras , 1995, Somatic cell and molecular genetics.

[199]  S. Ng,et al.  Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells , 1995, Molecular and cellular biology.

[200]  K. Arai,et al.  Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells. , 1995, Oncogene.

[201]  E. Thorsby,et al.  CD8+T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (GLY13→ASP), are cytotoxic towards a carcinoma cell line harbouring the same mutation , 1995, Cancer Immunology, Immunotherapy.

[202]  A. Robles,et al.  Induction of cyclin D1 overexpression by activated ras. , 1994, Oncogene.

[203]  P. Steeg,et al.  Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines , 1994, International journal of cancer.

[204]  D. Brenner,et al.  Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[205]  A. Giaccia,et al.  The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[206]  M. Gossen,et al.  Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. , 1994, Molecular and cellular biology.

[207]  S. Frisch,et al.  Disruption of epithelial cell-matrix interactions induces apoptosis , 1994, The Journal of cell biology.

[208]  S. Segal,et al.  The effect of H-ras expression on tumorigenicity and immunogenicity of Balb/c 3T3 fibroblasts. , 1993, Immunology letters.

[209]  S. Shurtleff,et al.  Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. , 1993, Genes & development.

[210]  M. Weber,et al.  Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. , 1993, Science.

[211]  I. Schlichting,et al.  Studies on the structure and mechanism of H-ras p21. , 1992, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[212]  J. Zhao,et al.  Overexpression of H-ras oncogene induces resistance to the growth-inhibitory action of transforming growth factor beta-1 (TGF-beta 1) and alters the number and type of TGF-beta 1 receptors in rat intestinal epithelial cell clones. , 1992, Oncogene.

[213]  B. Wasylyk,et al.  Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter , 1991, Molecular and cellular biology.

[214]  P. Rabinovitch,et al.  Frequency and spectrum of c-Ki-ras mutations in human sporadic colon carcinoma, carcinomas arising in ulcerative colitis, and pancreatic adenocarcinoma. , 1991, Environmental health perspectives.

[215]  G. Capellá,et al.  Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. , 1991, Environmental health perspectives.

[216]  H. Kole,et al.  Regulation of 6-phosphofructo-1-kinase activity in ras-transformed rat-1 fibroblasts. , 1991, Archives of biochemistry and biophysics.

[217]  A. Morris,et al.  Reduced stimulation of helper T cells by Ki-ras transformed cells. , 1991, Immunology.

[218]  L. Diamond,et al.  High expression of ras p21 correlates with increased rate of abnormal mitosis in NIH3T3 cells. , 1990, Oncogene.

[219]  J. L. Bos,et al.  ras oncogenes in human cancer: a review. , 1989, Cancer research.

[220]  R. Medcalf,et al.  Urokinase‐type plasminogen activator biosynthesis is induced by the EJ‐Ha‐ras oncogene in CL26 mouse colon carcinoma cells , 1989, International journal of cancer.

[221]  D. Hanahan,et al.  Induction of angiogenesis during the transition from hyperplasia to neoplasia , 1989, Nature.

[222]  R. Hynes,et al.  Changes in integrin receptors on oncogenically transformed cells , 1989, Cell.

[223]  H. Lodish,et al.  Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. , 1987, Science.

[224]  T. Curran,et al.  Microinjection of transforming ras protein induces c-fos expression , 1987, Molecular and cellular biology.

[225]  A. Chambers,et al.  Experimental metastatic ability of H-ras-transformed NIH3T3 cells. , 1985, Cancer research.

[226]  L. Liotta,et al.  Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell. , 1985, The American journal of pathology.

[227]  P. Seeburg,et al.  Biological properties of human c-Ha-ras1 genes mutated at codon 12 , 1984, Nature.

[228]  H. Kung,et al.  Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein , 1984, Nature.

[229]  J. Feramisco,et al.  Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells , 1984, Cell.

[230]  Allan Balmain,et al.  Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas , 1984, Nature.

[231]  O. Warburg [Origin of cancer cells]. , 1956, Oncologia.

[232]  K. Venkatasubbarao,et al.  Downregulation of PAR‐4, a pro‐apoptotic gene, in pancreatic tumors harboring K‐ras mutation , 2008, International journal of cancer.

[233]  G. Collins The next generation. , 2006, Scientific American.

[234]  Marta Cascante,et al.  K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts. , 2005, Cancer research.

[235]  J. Pouysségur,et al.  MAP Kinases and Hypoxia in the Control of VEGF Expression , 2004, Cancer and Metastasis Reviews.

[236]  J. Parkhill,et al.  Split personalities. , 2002, Trends in microbiology.

[237]  R. Kerbel,et al.  Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells. , 2000, The Journal of cell biology.

[238]  J. Massagué How cells read TGF-beta signals. , 2000, Nature reviews. Molecular cell biology.

[239]  Y. Fukui Cyclin D1 Expression Mediated by Phosphatidylinositol 3-Kinase through mTOR-p70 S6K -Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts , 1999 .

[240]  F. White,et al.  VEGF mRNA is stabilized by ras and tyrosine kinase oncogenes, as well as by UV radiation--evidence for divergent stabilization pathways. , 1997, Growth factors.

[241]  R M Chau,et al.  [Cell cycle and apoptosis]. , 1996, Sheng li ke xue jin zhan [Progress in physiology].

[242]  K. Johnson An Update. , 1984, Journal of food protection.