Source Imaging of P300 Visual Evoked Potentials and Cognitive Functions in Healthy Subjects

The P300 event-related potential (EPR) is regarded as a neurophysiological indicator of cognitive processing of a stimulus. However, it is not known whether the P300 is a unitary component recorded on the scalp as a result of the activity of a specific intracerebral structure, or if it represents the sum of underlying components that may reflect the activation of broadly distributed intracerebral structures. The objective of the present experiment was to investigate possible correlations among the source(s) involved in the generation of the P300 and their possible neurocognitive function. The visual-evoked potential (VEP) was elicited by the oddball paradigm and analyzed after employment of sLORETA (standardized low-resolution electromagnetic tomography). The window of the P300 wave encompasses the period during which the response to the target and nontarget condition differs significantly (≈375 ms to ≈465 ms, with a peak at ≈422.5 ms). The results showed sequential and what appeared to be logical activation patterns of specific structures (specific for the processing of the stimulus used here) after presentation of the target stimulus. The peak of the P300 wave represented activation of the parahippocampal gyrus, which is responsible for upgrading memory in response to a target stimulus.

[1]  E. Tulving,et al.  Novelty encoding networks in the human brain: positron emission tomography data. , 1994, Neuroreport.

[2]  P. Goldman-Rakic,et al.  Infrequent events transiently activate human prefrontal and parietal cortex as measured by functional MRI. , 1997, Journal of neurophysiology.

[3]  Thomas E. Nichols,et al.  Nonparametric permutation tests for functional neuroimaging: A primer with examples , 2002, Human brain mapping.

[4]  R. Goebel,et al.  The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks. , 1999, Cerebral cortex.

[5]  David J Madden,et al.  Processing speed and memory mediate age-related differences in decision making. , 2010, Psychology and aging.

[6]  Rosemary A. Rosser,et al.  Cognitive Markers of Adolescent Risk Taking: A Correlate of Drug Abuse in At-Risk Individuals , 2005 .

[7]  R. Dolan,et al.  Prefrontal Contributions to Metacognition in Perceptual Decision Making , 2012, The Journal of Neuroscience.

[8]  J. R. Baker,et al.  The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Rhawn Joseph.  Neuropsychiatry, neuropsychology, and clinical neuroscience , 1996 .

[10]  X. Wang,et al.  Synaptic Basis of Cortical Persistent Activity: the Importance of NMDA Receptors to Working Memory , 1999, The Journal of Neuroscience.

[11]  Gustavo Deco,et al.  Weber's Law in Decision Making: Integrating Behavioral Data in Humans with a Neurophysiological Model , 2007, The Journal of Neuroscience.

[12]  E. Leibenluft,et al.  Developmental effects of decision-making on sensitivity to reward: An fMRI study , 2012, Developmental Cognitive Neuroscience.

[13]  C. C. Wood,et al.  Potentials evoked in human and monkey medial temporal lobe during auditory and visual oddball paradigms. , 1992, Electroencephalography and clinical neurophysiology.

[14]  Rugg,et al.  Interpreting event-related brain potentials. , 2004 .

[15]  Ranulfo Romo,et al.  Flexible Control of Mutual Inhibition: A Neural Model of Two-Interval Discrimination , 2005, Science.

[16]  A. Papanicolaou,et al.  Visual evoked magnetic fields reveal activity in the superior temporal sulcus. , 1993, Electroencephalography and clinical neurophysiology.

[17]  J. Polich,et al.  P300 as a clinical assay: rationale, evaluation, and findings. , 2000, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[18]  R. Knight.  Distributed Cortical Network for Visual Attention , 1997, Journal of Cognitive Neuroscience.

[19]  J. Polich.  Updating P300: An integrative theory of P3a and P3b , 2007, Clinical Neurophysiology.

[20]  R. Knight,et al.  Neural origins of the P300. , 2000, Critical reviews in neurobiology.

[21]  J. Gläscher,et al.  Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex , 2012, Proceedings of the National Academy of Sciences.

[22]  Hanli Liu,et al.  Comparison of neural correlates of risk decision making between genders: An exploratory fNIRS study of the Balloon Analogue Risk Task (BART) , 2012, NeuroImage.

[23]  John A. Detre,et al.  Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI Study of the Balloon Analog Risk Task (BART) , 2008, NeuroImage.

[24]  S. Rauch,et al.  Neural mechanisms of decision making in hoarding disorder. , 2012, Archives of general psychiatry.

[25]  D. Lehmann,et al.  Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[26]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[27]  P. Goldman-Rakic,et al.  Prefrontal Activation Evoked by Infrequent Target and Novel Stimuli in a Visual Target Detection Task: An Event-Related Functional Magnetic Resonance Imaging Study , 2000, The Journal of Neuroscience.

[28]  Daeyeol Lee,et al.  Beyond working memory: the role of persistent activity in decision making , 2010, Trends in Cognitive Sciences.

[29]  Aditya Murthy,et al.  Brain mechanisms controlling decision making and motor planning. , 2013, Progress in brain research.

[30]  Daniel Houser,et al.  Emotion regulation and decision making under risk and uncertainty. , 2010, Emotion.

[31]  Gidon Felsen,et al.  Midbrain contributions to sensorimotor decision making. , 2012, Journal of neurophysiology.

[32]  Todd C. Handy,et al.  Event-related potentials : a methods handbook , 2005 .

[33]  Michael Falkenstein,et al.  Diversity of the P3 in the task-switching paradigm , 2011, Brain Research.

[34]  A. Papanicolaou,et al.  Electric source localization of the auditory P300 agrees with magnetic source localization. , 1995, Electroencephalography and clinical neurophysiology.