The human mirror neuron system: a link between action observation and social skills.

The discovery of the mirror neuron system (MNS) has led researchers to speculate that this system evolved from an embodied visual recognition apparatus in monkey to a system critical for social skills in humans. It is accepted that the MNS is specialized for processing animate stimuli, although the degree to which social interaction modulates the firing of mirror neurons has not been investigated. In the current study, EEG mu wave suppression was used as an index of MNS activity. Data were collected while subjects viewed four videos: (1) Visual White Noise: baseline, (2) Non-interacting: three individuals tossed a ball up in the air to themselves, (3) Social Action, Spectator: three individuals tossed a ball to each other and (4) Social Action, Interactive: similar to video 3 except occasionally the ball would be thrown off the screen toward the viewer. The mu wave was modulated by the degree of social interaction, with the Non-interacting condition showing the least suppression, followed by the Social Action, Spectator condition and the Social Action, Interactive condition showing the most suppression. These data suggest that the human MNS is specialized not only for processing animate stimuli, but specifically stimuli with social relevance.

[1]  Walter Wg,et al.  The electrical activity of the brain. , 1949 .

[2]  H. Gastaut,et al.  EEG changes during cinematographic presentation; moving picture activation of the EEG. , 1954, Electroencephalography and clinical neurophysiology.

[3]  P. Strick,et al.  Frontal lobe inputs to primate motor cortex: evidence for four somatotopically organized ‘premotor’ areas , 1979, Brain Research.

[4]  G. Rizzolatti,et al.  Afferent and efferent projections of the inferior area 6 in the macaque monkey , 1986, The Journal of comparative neurology.

[5]  C. G. Phillips,et al.  A quantitative study of the distribution of neurons projecting to the precentral motor cortex in the monkey (M. fascicularis) , 1987, The Journal of comparative neurology.

[6]  G. Rizzolatti,et al.  Motor facilitation during action observation: a magnetic stimulation study. , 1995, Journal of neurophysiology.

[7]  L. Parsons,et al.  Use of implicit motor imagery for visual shape discrimination as revealed by PET , 1995, Nature.

[8]  G. Pfurtscheller,et al.  Foot and hand area mu rhythms. , 1997, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[9]  A. Meltzoff,et al.  Explaining Facial Imitation: A Theoretical Model. , 1997, Early development & parenting.

[10]  W. Klimesch,et al.  Induced alpha band power changes in the human EEG and attention , 1998, Neuroscience Letters.

[11]  M. Arbib,et al.  Language within our grasp , 1998, Trends in Neurosciences.

[12]  G. Rizzolatti,et al.  Grasping objects and grasping action meanings: the dual role of monkey rostroventral premotor cortex (area F5). , 1998, Novartis Foundation symposium.

[13]  S. Cochin,et al.  Perception of motion and qEEG activity in human adults. , 1998, Electroencephalography and clinical neurophysiology.

[14]  J. Mazziotta,et al.  Cortical mechanisms of human imitation. , 1999, Science.

[15]  Goldensohn’s EEG Interpretation: Problems of Overreading and Underreading. , 2000 .

[16]  R. Hari,et al.  Temporal dynamics of cortical representation for action. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[17]  A. Nambu,et al.  Organization of nonprimary motor cortical inputs on pyramidal and nonpyramidal tract neurons of primary motor cortex: An electrophysiological study in the macaque monkey. , 2000, Cerebral cortex.

[18]  B. Allison,et al.  The effects of self-movement, observation, and imagination on mu rhythms and readiness potentials (RP's): toward a brain-computer interface (BCI). , 2000, IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.

[19]  G. Rizzolatti,et al.  Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study , 2001, The European journal of neuroscience.

[20]  J C Mazziotta,et al.  Reafferent copies of imitated actions in the right superior temporal cortex , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[21]  G. Rizzolatti,et al.  Neurophysiological mechanisms underlying the understanding and imitation of action , 2001, Nature Reviews Neuroscience.

[22]  V. Gallese.  The 'shared manifold' hypothesis: From mirror neurons to empathy. , 2001 .

[23]  Febo Cincotti,et al.  Human Cortical Electroencephalography (EEG) Rhythms during the Observation of Simple Aimless Movements: A High-Resolution EEG Study , 2002, NeuroImage.

[24]  P. Strick,et al.  Motor areas in the frontal lobe of the primate , 2002, Physiology & Behavior.

[25]  G. Rizzolatti,et al.  Both of Us Disgusted in My Insula The Common Neural Basis of Seeing and Feeling Disgust , 2003, Neuron.

[26]  Shaomin Li,et al.  The Great Leap Forward: The Transition from Relation-Based Governance to Rule-Based Governance , 2004 .

[27]  R. Lemon,et al.  Cortical afferents and efferents of monkey postarcuate area: an anatomical and electrophysiological study , 2004, Experimental Brain Research.

[28]  R. Hari,et al.  Abnormal imitation‐related cortical activation sequences in Asperger's syndrome , 2004, Annals of neurology.

[29]  G. Rizzolatti,et al.  A unifying view of the basis of social cognition , 2004, Trends in Cognitive Sciences.

[30]  G. Rizzolatti,et al.  Understanding motor events: a neurophysiological study , 2004, Experimental Brain Research.

[31]  Blake W. Johnson,et al.  Mu rhythm modulation during observation of an object-directed grasp. , 2004, Brain research. Cognitive brain research.

[32]  R. Lemon,et al.  Macaque ventral premotor cortex exerts powerful facilitation of motor cortex outputs to upper limb motoneurons. , 2004, The Journal of Neuroscience.

[33]  Blake W. Johnson,et al.  Primary motor cortex activation during action observation revealed by wavelet analysis of the EEG , 2004, Clinical Neurophysiology.

[34]  Istvan Molnar-Szakacs,et al.  Watching social interactions produces dorsomedial prefrontal and medial parietal BOLD fMRI signal increases compared to a resting baseline , 2004, NeuroImage.

[35]  J. O'Doherty,et al.  Empathy for Pain Involves the Affective but not Sensory Components of Pain , 2004, Science.

[36]  G. Pellegrino,et al.  Vicarious responses to pain in anterior cingulate cortex: Is empathy a multisensory issue? , 2004, Cognitive, affective & behavioral neuroscience.

[37]  J. Pineda.  The functional significance of mu rhythms: Translating “seeing” and “hearing” into “doing” , 2005, Brain Research Reviews.

[38]  Á. Pascual-Leone,et al.  Impaired motor facilitation during action observation in individuals with autism spectrum disorder , 2005, Current Biology.

[39]  Ralph-Axel Müller,et al.  Reduced functional connectivity between V1 and inferior frontal cortex associated with visuomotor performance in autism , 2005, NeuroImage.

[40]  Ton Bisseling,et al.  Biology by Numbers—Introducing Quantitation into Life Science Education , 2005, PLoS biology.

[41]  Joseph P. McCleery,et al.  EEG evidence for mirror neuron dysfunction in autism spectrum disorders. , 2005, Brain research. Cognitive brain research.

[42]  J. Mazziotta,et al.  Grasping the Intentions of Others with One's Own Mirror Neuron System , 2005, PLoS biology.

[43]  Jennifer H. Pfeifer,et al.  Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders , 2006, Nature Neuroscience.