Deep Neural Architectures for Medical Image Semantic Segmentation: Review

Deep learning has an enormous impact on medical image analysis. Many computer-aided diagnostic systems equipped with deep networks are rapidly reducing human intervention in healthcare. Among several applications, medical image semantic segmentation is one of the core areas of active research to delineate the anatomical structures and other regions of interest. It has a significant contribution to healthcare and provides guided interventions, radiotherapy, and improved radiological diagnostics. The underlying article provides a brief overview of deep convolutional neural architecture, the platforms and applications of deep neural networks, metrics used for empirical evaluation, state-of-the-art semantic segmentation architectures based on a foundational convolution concept, and a review of publicly available medical image datasets highlighting four distinct regions of interest. The article also analyzes the existing work and provides open-ended potential research directions in deep medical image semantic segmentation.

[1]  Sergey Ioffe,et al.  Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift , 2015, ICML.

[2]  Nico Karssemeijer,et al.  Transfer Learning for Domain Adaptation in MRI: Application in Brain Lesion Segmentation , 2017, MICCAI.

[3]  Ana Maria Mendonça,et al.  End-to-End Adversarial Retinal Image Synthesis , 2018, IEEE Transactions on Medical Imaging.

[4]  Bram van Ginneken,et al.  A survey on deep learning in medical image analysis , 2017, Medical Image Anal..

[5]  Chi-Wing Fu,et al.  Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation , 2019, MICCAI.

[6]  Martín Abadi,et al.  TensorFlow: Large-Scale Machine Learning on Heterogeneous Distributed Systems , 2016, ArXiv.

[7]  Yanrong Guo,et al.  A Brief Survey on Semantic Segmentation with Deep Learning , 2020, Neurocomputing.

[8]  Kilian Q. Weinberger,et al.  Densely Connected Convolutional Networks , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[9]  Nima Tajbakhsh,et al.  UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation , 2020, IEEE Transactions on Medical Imaging.

[10]  Enzo Ferrante,et al.  Anatomical Priors for Image Segmentation via Post-Processing with Denoising Autoencoders , 2019, MICCAI.

[11]  Gyu Sang Choi,et al.  COVINet: a convolutional neural network approach for predicting COVID-19 from chest X-ray images , 2021, Journal of ambient intelligence and humanized computing.

[12]  Konstantinos Kamnitsas,et al.  Ensembles of Multiple Models and Architectures for Robust Brain Tumour Segmentation , 2017, BrainLes@MICCAI.

[13]  Shenghua Gao,et al.  CE-Net: Context Encoder Network for 2D Medical Image Segmentation , 2019, IEEE Transactions on Medical Imaging.

[14]  Xiaochun Cao,et al.  Joint Optic Disc and Cup Segmentation Based on Multi-Label Deep Network and Polar Transformation , 2018, IEEE Transactions on Medical Imaging.

[15]  Venkateswararao Cherukuri,et al.  Learning Based Segmentation of CT Brain Images: Application to Postoperative Hydrocephalic Scans , 2017, IEEE Transactions on Biomedical Engineering.

[16]  Naimul Mefraz Khan,et al.  A Novel Focal Tversky Loss Function With Improved Attention U-Net for Lesion Segmentation , 2018, 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019).

[17]  Daniel Rueckert,et al.  Discriminative dictionary learning for abdominal multi-organ segmentation , 2015, Medical Image Anal..

[18]  Xiangjian He,et al.  Deep Learning Techniques for Medical Image Segmentation: Achievements and Challenges , 2019, Journal of Digital Imaging.

[19]  Xiaoying Tang,et al.  A Survey on Deep Learning of Small Sample in Biomedical Image Analysis , 2019, ArXiv.

[20]  Marius George Linguraru,et al.  Abdominal multi-organ segmentation from CT images using conditional shape-location and unsupervised intensity priors , 2015, Medical Image Anal..

[21]  Min Xian,et al.  Attention Enriched Deep Learning Model for Breast Tumor Segmentation in Ultrasound Images , 2019, Ultrasound in medicine & biology.

[22]  Enzo Ferrante,et al.  Post-DAE: Anatomically Plausible Segmentation via Post-Processing With Denoising Autoencoders , 2020, IEEE Transactions on Medical Imaging.

[23]  Ioannis Mitliagkas,et al.  Manifold Mixup: Better Representations by Interpolating Hidden States , 2018, ICML.

[24]  Jianxin Wang,et al.  Efficient multi-kernel DCNN with pixel dropout for stroke MRI segmentation , 2019, Neurocomputing.

[25]  Yuichiro Hayashi,et al.  An application of cascaded 3D fully convolutional networks for medical image segmentation , 2018, Comput. Medical Imaging Graph..

[26]  Collin M. Stultz,et al.  Deep Learning for Cardiovascular Risk Stratification , 2020, Current Treatment Options in Cardiovascular Medicine.

[27]  Kai Ma,et al.  Self-Loop Uncertainty: A Novel Pseudo-Label for Semi-Supervised Medical Image Segmentation , 2020, MICCAI.

[28]  Yanping Zhang,et al.  Cardiac-DeepIED: Automatic Pixel-Level Deep Segmentation for Cardiac Bi-Ventricle Using Improved End-to-End Encoder-Decoder Network , 2019, IEEE Journal of Translational Engineering in Health and Medicine.

[29]  Sébastien Ourselin,et al.  Automatic Brain Tumor Segmentation Using Cascaded Anisotropic Convolutional Neural Networks , 2017, BrainLes@MICCAI.

[30]  Jialin Peng,et al.  Medical Image Segmentation With Limited Supervision: A Review of Deep Network Models , 2021, IEEE Access.

[31]  Yanchun Zhang,et al.  MDU-Net: multi-scale densely connected U-Net for biomedical image segmentation , 2018, Health Information Science and Systems.

[32]  Nikos Paragios,et al.  AtlasNet: Multi-atlas Non-linear Deep Networks for Medical Image Segmentation , 2018, MICCAI.

[33]  Klaus H. Maier-Hein,et al.  Brain Tumor Segmentation and Radiomics Survival Prediction: Contribution to the BRATS 2017 Challenge , 2017, BrainLes@MICCAI.

[34]  Mahmood Fathy,et al.  Bi-Directional ConvLSTM U-Net with Densley Connected Convolutions , 2019, 2019 IEEE/CVF International Conference on Computer Vision Workshop (ICCVW).

[35]  Zhenyu Liu,et al.  Central focused convolutional neural networks: Developing a data-driven model for lung nodule segmentation , 2017, Medical Image Anal..

[36]  Tuan D. Pham,et al.  DUNet: A deformable network for retinal vessel segmentation , 2018, Knowl. Based Syst..

[37]  Daniel Rueckert,et al.  Realistic Adversarial Data Augmentation for MR Image Segmentation , 2020, MICCAI.

[38]  Lukasz Kaiser,et al.  Attention is All you Need , 2017, NIPS.

[39]  George Papandreou,et al.  Rethinking Atrous Convolution for Semantic Image Segmentation , 2017, ArXiv.

[40]  Shaohua Kevin Zhou,et al.  Less is More: Simultaneous View Classification and Landmark Detection for Abdominal Ultrasound Images , 2018, MICCAI.

[41]  Dhimas Arief Dharmawan,et al.  Residual U-Net for Retinal Vessel Segmentation , 2019, 2019 IEEE International Conference on Image Processing (ICIP).

[42]  Shahrokh Valaee,et al.  Recent Advances in Recurrent Neural Networks , 2017, ArXiv.

[43]  Martin Styner,et al.  Comparison and Evaluation of Methods for Liver Segmentation From CT Datasets , 2009, IEEE Transactions on Medical Imaging.

[44]  Pengtao Xie,et al.  On the Automatic Generation of Medical Imaging Reports , 2017, ACL.

[45]  Antonio J. Plaza,et al.  Image Segmentation Using Deep Learning: A Survey , 2021, IEEE transactions on pattern analysis and machine intelligence.

[46]  Chengwen Chu,et al.  Multi‐atlas pancreas segmentation: Atlas selection based on vessel structure , 2017, Medical Image Anal..

[47]  Le Lu,et al.  Pancreas Segmentation in CT and MRI Images via Domain Specific Network Designing and Recurrent Neural Contextual Learning , 2018, ArXiv.

[48]  Klaus H. Maier-Hein,et al.  Retina U-Net: Embarrassingly Simple Exploitation of Segmentation Supervision for Medical Object Detection , 2018, ML4H@NeurIPS.

[49]  Vishal M. Patel,et al.  Learning to Segment Brain Anatomy From 2D Ultrasound With Less Data , 2019, IEEE Journal of Selected Topics in Signal Processing.

[50]  Hongyu Guo,et al.  MixUp as Locally Linear Out-Of-Manifold Regularization , 2018, AAAI.

[51]  Jon Kleinberg,et al.  Transfusion: Understanding Transfer Learning for Medical Imaging , 2019, NeurIPS.

[52]  Hermann Ney,et al.  LSTM Neural Networks for Language Modeling , 2012, INTERSPEECH.

[53]  Sofia Vallecorsa,et al.  3D convolutional GAN for fast simulation , 2019, EPJ Web of Conferences.

[54]  Aaron Carass,et al.  DeepHarmony: A deep learning approach to contrast harmonization across scanner changes. , 2019, Magnetic resonance imaging.

[55]  Gongfa Li,et al.  Jointly network image processing: multi-task image semantic segmentation of indoor scene based on CNN , 2020, IET Image Process..

[56]  Stefan Klein,et al.  Improving Robustness of Deep Learning Based Knee MRI Segmentation: Mixup and Adversarial Domain Adaptation , 2019, 2019 IEEE/CVF International Conference on Computer Vision Workshop (ICCVW).

[57]  Wei-Shi Zheng,et al.  Fully convolutional network ensembles for white matter hyperintensities segmentation in MR images , 2018, NeuroImage.

[58]  Joseph Paul Cohen,et al.  Deep semantic segmentation of natural and medical images: a review , 2019, Artificial Intelligence Review.

[59]  Qiegen Liu,et al.  X-Net: Brain Stroke Lesion Segmentation Based on Depthwise Separable Convolution and Long-range Dependencies , 2019, MICCAI.

[60]  Michael A. Riegler,et al.  DoubleU-Net: A Deep Convolutional Neural Network for Medical Image Segmentation , 2020, 2020 IEEE 33rd International Symposium on Computer-Based Medical Systems (CBMS).

[61]  Zhenan Sun,et al.  Accurate iris segmentation in non-cooperative environments using fully convolutional networks , 2016, 2016 International Conference on Biometrics (ICB).

[62]  Paul Babyn,et al.  Generative Adversarial Network in Medical Imaging: A Review , 2018, Medical Image Anal..

[63]  Nicholas J. Tustison,et al.  Brain Tumor Segmentation Using an Ensemble of 3D U-Nets and Overall Survival Prediction Using Radiomic Features , 2018, Frontiers in Computational Neuroscience.

[64]  Andreas K. Maier,et al.  Dilated Convolutions in Neural Networks for Left Atrial Segmentation in 3D Gadolinium Enhanced-MRI , 2018, STACOM@MICCAI.

[65]  Svetlana Lazebnik,et al.  Multi-scale Orderless Pooling of Deep Convolutional Activation Features , 2014, ECCV.

[66]  Christoph Meinel,et al.  Recurrent generative adversarial network for learning imbalanced medical image semantic segmentation , 2019, Multimedia Tools and Applications.

[67]  Thomas Brox,et al.  Striving for Simplicity: The All Convolutional Net , 2014, ICLR.

[68]  Subhashree Mohapatra,et al.  Deep convolutional neural network in medical image processing , 2021 .

[69]  Kaiming He,et al.  Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks , 2015, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[70]  Daniel Rueckert,et al.  Computational Anatomy for Multi-Organ Analysis in Medical Imaging: A Review , 2018, Medical Image Anal..

[71]  Xuejun Gu,et al.  Deep learning-based medical image segmentation with limited labels , 2020, Physics in medicine and biology.

[72]  Anselmo Cardoso de Paiva,et al.  Convolutional neural network-based PSO for lung nodule false positive reduction on CT images , 2018, Comput. Methods Programs Biomed..

[73]  Chi-Wing Fu,et al.  H-DenseUNet: Hybrid Densely Connected UNet for Liver and Tumor Segmentation From CT Volumes , 2018, IEEE Transactions on Medical Imaging.

[74]  Jongyoul Park,et al.  CenterMask: Real-Time Anchor-Free Instance Segmentation , 2020, 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR).

[75]  José García Rodríguez,et al.  A survey on deep learning techniques for image and video semantic segmentation , 2018, Appl. Soft Comput..

[76]  Yugen Yi,et al.  SA-UNet: Spatial Attention U-Net for Retinal Vessel Segmentation , 2020, 2020 25th International Conference on Pattern Recognition (ICPR).

[77]  Xavier Lladó,et al.  SUNet: a deep learning architecture for acute stroke lesion segmentation and outcome prediction in multimodal MRI , 2018, ArXiv.

[78]  Yu Liu,et al.  A review of semantic segmentation using deep neural networks , 2017, International Journal of Multimedia Information Retrieval.

[79]  Hao Chen,et al.  VoxResNet: Deep voxelwise residual networks for brain segmentation from 3D MR images , 2017, NeuroImage.

[80]  Ali Gooya,et al.  Fully automatic detection of lung nodules in CT images using a hybrid feature set , 2017, Medical physics.

[81]  Jialin Peng,et al.  Unsupervised Mitochondria Segmentation in EM Images via Domain Adaptive Multi-Task Learning , 2020, IEEE Journal of Selected Topics in Signal Processing.

[82]  Jian Sun,et al.  Deep Residual Learning for Image Recognition , 2015, 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[83]  Xiaolin Huang,et al.  Pulmonary nodule segmentation with CT sample synthesis using adversarial networks , 2019, Medical physics.

[84]  Anuj Bhardwaj,et al.  A review on brain tumor segmentation of MRI images. , 2019, Magnetic resonance imaging.

[85]  Trevor Darrell,et al.  Fully Convolutional Networks for Semantic Segmentation , 2017, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[86]  Jialin Peng,et al.  Mitochondria Segmentation From EM Images via Hierarchical Structured Contextual Forest , 2019, IEEE Journal of Biomedical and Health Informatics.

[87]  Ender Konukoglu,et al.  Joint reconstruction and bias field correction for undersampled MR imaging , 2020, MICCAI.

[88]  Yoshua Bengio,et al.  Attention-Based Models for Speech Recognition , 2015, NIPS.

[89]  Sanja Fidler,et al.  Towards Diverse and Natural Image Descriptions via a Conditional GAN , 2017, 2017 IEEE International Conference on Computer Vision (ICCV).

[90]  Bjoern H. Menze,et al.  Automatic Brain Structures Segmentation Using Deep Residual Dilated U-Net , 2018, BrainLes@MICCAI.

[91]  Kazuyoshi Imaizumi,et al.  Multiplanar analysis for pulmonary nodule classification in CT images using deep convolutional neural network and generative adversarial networks , 2019, International Journal of Computer Assisted Radiology and Surgery.

[92]  Daguang Xu,et al.  3D Anisotropic Hybrid Network: Transferring Convolutional Features from 2D Images to 3D Anisotropic Volumes , 2017, MICCAI.

[93]  Xiaogang Wang,et al.  Pyramid Scene Parsing Network , 2016, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[94]  Deyu Meng,et al.  LT-Net: Label Transfer by Learning Reversible Voxel-Wise Correspondence for One-Shot Medical Image Segmentation , 2020, 2020 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR).

[95]  Frédo Durand,et al.  Data augmentation using learned transforms for one-shot medical image segmentation , 2019, ArXiv.

[96]  Konstantinos Kamnitsas,et al.  Anatomically Constrained Neural Networks (ACNNs): Application to Cardiac Image Enhancement and Segmentation , 2017, IEEE Transactions on Medical Imaging.

[97]  Max A. Viergever,et al.  A deep learning framework for unsupervised affine and deformable image registration , 2018, Medical Image Anal..

[98]  Xuanqin Mou,et al.  Machine Learning for Tomographic Imaging , 2020 .

[99]  Yinghuan Shi,et al.  Ea-GANs: Edge-Aware Generative Adversarial Networks for Cross-Modality MR Image Synthesis , 2019, IEEE Transactions on Medical Imaging.

[100]  Ali Gholipour,et al.  Semi-Supervised Learning With Deep Embedded Clustering for Image Classification and Segmentation , 2019, IEEE Access.

[101]  Mohammad Sohel Rahman,et al.  MultiResUNet : Rethinking the U-Net Architecture for Multimodal Biomedical Image Segmentation , 2019, Neural Networks.

[102]  Shaojie Tang,et al.  A survey on incorporating domain knowledge into deep learning for medical image analysis , 2020, Medical Image Anal..

[103]  Jürgen Schmidhuber,et al.  Framewise phoneme classification with bidirectional LSTM and other neural network architectures , 2005, Neural Networks.

[104]  Kunihiko Fukushima,et al.  Neocognitron: A Self-Organizing Neural Network Model for a Mechanism of Visual Pattern Recognition , 1982 .

[105]  Frank Lindseth,et al.  Medical image segmentation on GPUs - A comprehensive review , 2015, Medical Image Anal..

[106]  Jianhua Lu,et al.  Dense Convolutional Networks for Semantic Segmentation , 2019, IEEE Access.

[107]  Nima Tajbakhsh,et al.  Embracing Imperfect Datasets: A Review of Deep Learning Solutions for Medical Image Segmentation , 2019, Medical Image Anal..

[108]  Seyed-Ahmad Ahmadi,et al.  V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation , 2016, 2016 Fourth International Conference on 3D Vision (3DV).

[109]  Thomas Brox,et al.  3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation , 2016, MICCAI.

[110]  Phil Blunsom,et al.  Teaching Machines to Read and Comprehend , 2015, NIPS.

[111]  Yinghuan Shi,et al.  Interactive medical image segmentation via a point-based interaction , 2021, Artif. Intell. Medicine.

[112]  D. Rueckert,et al.  Self-Supervision with Superpixels: Training Few-shot Medical Image Segmentation without Annotation , 2020, ECCV.

[113]  Jasper Snoek,et al.  Spectral Representations for Convolutional Neural Networks , 2015, NIPS.

[114]  Xiaochun Cao,et al.  Survey of recent progress in semantic image segmentation with CNNs , 2017, Science China Information Sciences.

[115]  Yu-Dong Yao,et al.  An effective computer aided diagnosis model for pancreas cancer on PET/CT images , 2018, Comput. Methods Programs Biomed..

[116]  Juntang Zhuang,et al.  LadderNet: Multi-path networks based on U-Net for medical image segmentation , 2018, ArXiv.

[117]  Wei Wang,et al.  Deep Atlas Network for Efficient 3D Left Ventricle Segmentation on Echocardiography , 2020, Medical Image Anal..

[118]  Behzad Aliahmad,et al.  Fundus images analysis using deep features for detection of exudates, hemorrhages and microaneurysms , 2018, BMC Ophthalmology.

[119]  Hao Chen,et al.  DCAN: Deep contour‐aware networks for object instance segmentation from histology images , 2017, Medical Image Anal..

[120]  Anne L. Martel,et al.  Deep neural network models for computational histopathology: A survey , 2019, Medical Image Anal..

[121]  Yuta Nakashima,et al.  IterNet: Retinal Image Segmentation Utilizing Structural Redundancy in Vessel Networks , 2019, 2020 IEEE Winter Conference on Applications of Computer Vision (WACV).

[122]  Nima Tajbakhsh,et al.  Models Genesis: Generic Autodidactic Models for 3D Medical Image Analysis , 2019, MICCAI.

[123]  Yannick Le Moullec,et al.  Automatic detection of multisize pulmonary nodules in CT images: Large‐scale validation of the false‐positive reduction step , 2018, Medical physics.

[124]  Lubomir M. Hadjiiski,et al.  Computer-aided diagnosis in the era of deep learning. , 2020, Medical physics.

[125]  Jose Dolz,et al.  3D fully convolutional networks for subcortical segmentation in MRI: A large-scale study , 2016, NeuroImage.

[126]  Shin Ishii,et al.  Semi-supervised deep learning of brain tissue segmentation , 2019, Neural Networks.

[127]  Quoc V. Le,et al.  Swish: a Self-Gated Activation Function , 2017, 1710.05941.

[128]  Marc Niethammer,et al.  Anatomical Data Augmentation via Fluid-based Image Registration , 2020, MICCAI.

[129]  Li Wang,et al.  STRAINet: Spatially Varying sTochastic Residual AdversarIal Networks for MRI Pelvic Organ Segmentation , 2019, IEEE Transactions on Neural Networks and Learning Systems.

[130]  Jae Yeol Lee,et al.  M-GAN: Retinal Blood Vessel Segmentation by Balancing Losses Through Stacked Deep Fully Convolutional Networks , 2020, IEEE Access.

[131]  Il Dong Yun,et al.  Deep Vessel Segmentation By Learning Graphical Connectivity , 2018, Medical Image Anal..

[132]  Roberto Cipolla,et al.  SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation , 2015, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[133]  Nasir M. Rajpoot,et al.  Dual-Channel Active Contour Model for Megakaryocytic Cell Segmentation in Bone Marrow Trephine Histology Images , 2017, IEEE Transactions on Biomedical Engineering.

[134]  Paul Honeine,et al.  BB-UNet: U-Net With Bounding Box Prior , 2020, IEEE Journal of Selected Topics in Signal Processing.

[135]  René M. Botnar,et al.  Automatic CNN-based detection of cardiac MR motion artefacts using k-space data augmentation and curriculum learning , 2018, Medical Image Anal..

[136]  Loïc Le Folgoc,et al.  Attention U-Net: Learning Where to Look for the Pancreas , 2018, ArXiv.

[137]  Hanchao Yu,et al.  Study Group Learning: Improving Retinal Vessel Segmentation Trained with Noisy Labels , 2021, MICCAI.

[138]  Junfeng Chen,et al.  3D skeletonization feature based computer-aided detection system for pulmonary nodules in CT datasets , 2018, Comput. Biol. Medicine.

[139]  Dinggang Shen,et al.  Review of Artificial Intelligence Techniques in Imaging Data Acquisition, Segmentation, and Diagnosis for COVID-19 , 2020, IEEE Reviews in Biomedical Engineering.

[140]  Naeem Khalid Janjua,et al.  Going Deep in Medical Image Analysis: Concepts, Methods, Challenges, and Future Directions , 2019, IEEE Access.

[141]  Gadi Wollstein,et al.  Uncertainty Guided Semi-supervised Segmentation of Retinal Layers in OCT Images , 2019, MICCAI.

[142]  Yoshua Bengio,et al.  Generative Adversarial Nets , 2014, NIPS.

[143]  Ming Chao,et al.  Improving Dermoscopic Image Segmentation With Enhanced Convolutional-Deconvolutional Networks , 2017, IEEE Journal of Biomedical and Health Informatics.

[144]  Rutuparna Panda,et al.  State-of-the-Art Methods for Brain Tissue Segmentation: A Review , 2017, IEEE Reviews in Biomedical Engineering.

[145]  Vijayan K. Asari,et al.  Recurrent Residual Convolutional Neural Network based on U-Net (R2U-Net) for Medical Image Segmentation , 2018, ArXiv.

[146]  Phil Blunsom,et al.  A Convolutional Neural Network for Modelling Sentences , 2014, ACL.

[147]  Jian Sun,et al.  Spatial Pyramid Pooling in Deep Convolutional Networks for Visual Recognition , 2014, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[148]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.

[149]  Jiacheng Li,et al.  Connection Sensitive Attention U-NET for Accurate Retinal Vessel Segmentation , 2019, ArXiv.

[150]  Hongming Shan,et al.  3-D Convolutional Encoder-Decoder Network for Low-Dose CT via Transfer Learning From a 2-D Trained Network , 2018, IEEE Transactions on Medical Imaging.

[151]  Simon K. Warfield,et al.  Deep learning with noisy labels: exploring techniques and remedies in medical image analysis , 2020, Medical Image Anal..

[152]  Jiasong Wu,et al.  DPA-DenseBiasNet: Semi-supervised 3D Fine Renal Artery Segmentation with Dense Biased Network and Deep Priori Anatomy , 2019, MICCAI.

[153]  Silvio Savarese,et al.  Generalizing to Unseen Domains via Adversarial Data Augmentation , 2018, NeurIPS.

[154]  Yubo Fan,et al.  Deep learning in digital pathology image analysis: a survey , 2020, Frontiers of Medicine.

[155]  Luca Antiga,et al.  Automatic differentiation in PyTorch , 2017 .

[156]  Yann LeCun,et al.  Regularization of Neural Networks using DropConnect , 2013, ICML.

[157]  Dorin Comaniciu,et al.  Search strategies for multiple landmark detection by submodular maximization , 2010, 2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition.

[158]  Yoshua Bengio,et al.  Neural Machine Translation by Jointly Learning to Align and Translate , 2014, ICLR.

[159]  Marleen de Bruijne,et al.  Semi-supervised Medical Image Segmentation via Learning Consistency Under Transformations , 2019, MICCAI.

[160]  Daniel Rueckert,et al.  Deep Learning for Cardiac Image Segmentation: A Review , 2020, Frontiers in Cardiovascular Medicine.

[161]  Mert R. Sabuncu,et al.  Anatomical Priors in Convolutional Networks for Unsupervised Biomedical Segmentation , 2018, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[162]  Mohammad Reza Hosseinzadeh Taher,et al.  Learning Semantics-enriched Representation via Self-discovery, Self-classification, and Self-restoration , 2020, MICCAI.

[163]  D. Opitz,et al.  Popular Ensemble Methods: An Empirical Study , 1999, J. Artif. Intell. Res..

[164]  Ronald M. Summers,et al.  A Review of Deep Learning in Medical Imaging: Imaging Traits, Technology Trends, Case Studies With Progress Highlights, and Future Promises , 2020, Proceedings of the IEEE.

[165]  Md Zahangir Alom,et al.  Recurrent residual U-Net for medical image segmentation , 2019, Journal of medical imaging.

[166]  Liang Chen,et al.  DRINet for Medical Image Segmentation , 2018, IEEE Transactions on Medical Imaging.

[167]  Jong Chul Ye,et al.  Framing U-Net via Deep Convolutional Framelets: Application to Sparse-View CT , 2017, IEEE Transactions on Medical Imaging.

[168]  Atsushi Saito,et al.  Joint optimization of segmentation and shape prior from level-set-based statistical shape model, and its application to the automated segmentation of abdominal organs , 2016, Medical Image Anal..

[169]  Elena De Momi,et al.  Blood vessel segmentation algorithms - Review of methods, datasets and evaluation metrics , 2018, Comput. Methods Programs Biomed..

[170]  Geoffrey E. Hinton,et al.  ImageNet classification with deep convolutional neural networks , 2012, Commun. ACM.

[171]  Ross B. Girshick,et al.  Mask R-CNN , 2017, 1703.06870.

[172]  Kuanquan Wang,et al.  Multi-Depth Fusion Network for Whole-Heart CT Image Segmentation , 2019, IEEE Access.

[173]  D. Rueckert,et al.  White matter hyperintensity and stroke lesion segmentation and differentiation using convolutional neural networks , 2017, NeuroImage: Clinical.

[174]  Anselmo Cardoso de Paiva,et al.  3D shape analysis to reduce false positives for lung nodule detection systems , 2017, Medical & Biological Engineering & Computing.

[175]  Jianmin Wang,et al.  HashGAN: Deep Learning to Hash with Pair Conditional Wasserstein GAN , 2018, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[176]  Yi Pan,et al.  Deep convolutional neural network for automatically segmenting acute ischemic stroke lesion in multi-modality MRI , 2019, Neural Computing and Applications.

[177]  Peter M. Atkinson,et al.  MACU-Net for Semantic Segmentation of Fine-Resolution Remotely Sensed Images , 2022, IEEE Geoscience and Remote Sensing Letters.

[178]  Yutaro Iwamoto,et al.  Semi-supervised Segmentation of Liver Using Adversarial Learning with Deep Atlas Prior , 2019, MICCAI.

[179]  Xiang Li,et al.  Diagnosing Rotating Machines With Weakly Supervised Data Using Deep Transfer Learning , 2020, IEEE Transactions on Industrial Informatics.

[180]  Ender Konukoglu,et al.  Semi-Supervised and Task-Driven Data Augmentation , 2019, IPMI.

[181]  Antonio Jose Rodríguez-Sánchez,et al.  ISLES Challenge: U-Shaped Convolution Neural Network with Dilated Convolution for 3D Stroke Lesion Segmentation , 2018, BrainLes@MICCAI.

[182]  Konstantinos Kamnitsas,et al.  Efficient multi‐scale 3D CNN with fully connected CRF for accurate brain lesion segmentation , 2016, Medical Image Anal..

[183]  Alex Graves,et al.  Recurrent Models of Visual Attention , 2014, NIPS.

[184]  Jürgen Schmidhuber,et al.  Long Short-Term Memory , 1997, Neural Computation.

[185]  Yabo Fu,et al.  Deep Learning in Medical Image Registration: A Review , 2020, Physics in medicine and biology.

[186]  Usman Qamar,et al.  Towards Service Evaluation and Ranking Model for Cloud Infrastructure Selection , 2015, 2015 IEEE 12th Intl Conf on Ubiquitous Intelligence and Computing and 2015 IEEE 12th Intl Conf on Autonomic and Trusted Computing and 2015 IEEE 15th Intl Conf on Scalable Computing and Communications and Its Associated Workshops (UIC-ATC-ScalCom).

[187]  Christopher Joseph Pal,et al.  Learning normalized inputs for iterative estimation in medical image segmentation , 2017, Medical Image Anal..

[188]  Shuiwang Ji,et al.  Residual Deconvolutional Networks for Brain Electron Microscopy Image Segmentation , 2017, IEEE Transactions on Medical Imaging.

[189]  Lin Yang,et al.  Towards cross‐modal organ translation and segmentation: A cycle‐ and shape‐consistent generative adversarial network , 2019, Medical Image Anal..

[190]  Alan L. Yuille,et al.  Recurrent Saliency Transformation Network: Incorporating Multi-stage Visual Cues for Small Organ Segmentation , 2017, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[191]  Yoshua Bengio,et al.  Learning Phrase Representations using RNN Encoder–Decoder for Statistical Machine Translation , 2014, EMNLP.

[192]  Bin Zheng,et al.  Automatic detection of pulmonary nodules in CT images by incorporating 3D tensor filtering with local image feature analysis. , 2018, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[193]  Nitish Srivastava,et al.  Improving neural networks by preventing co-adaptation of feature detectors , 2012, ArXiv.

[194]  Muhammad Sharif,et al.  Multistage segmentation model and SVM-ensemble for precise lung nodule detection , 2018, International Journal of Computer Assisted Radiology and Surgery.

[195]  Xue-wen Chen,et al.  Big Data Deep Learning: Challenges and Perspectives , 2014, IEEE Access.

[196]  Marc Niethammer,et al.  Adversarial Data Augmentation via Deformation Statistics , 2020, ECCV.

[197]  Rob Fergus,et al.  Stochastic Pooling for Regularization of Deep Convolutional Neural Networks , 2013, ICLR.

[198]  Claudio Moraga,et al.  The Influence of the Sigmoid Function Parameters on the Speed of Backpropagation Learning , 1995, IWANN.

[199]  Iasonas Kokkinos,et al.  DeepLab: Semantic Image Segmentation with Deep Convolutional Nets, Atrous Convolution, and Fully Connected CRFs , 2016, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[200]  Alireza Tavakkoli,et al.  RV-GAN: Segmenting Retinal Vascular Structure in Fundus Photographs Using a Novel Multi-scale Generative Adversarial Network , 2021, MICCAI.

[201]  Jialin Peng,et al.  EM-Net: Centerline-Aware Mitochondria Segmentation in EM Images Via Hierarchical View-Ensemble Convolutional Network , 2020, 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI).

[202]  Mazhar Shaikh,et al.  Brain Tumor Segmentation Using Dense Fully Convolutional Neural Network , 2017, BrainLes@MICCAI.

[203]  Syed Muhammad Anwar,et al.  Brain tumor segmentation using cascaded deep convolutional neural network , 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[204]  Marc Niethammer,et al.  DeepAtlas: Joint Semi-Supervised Learning of Image Registration and Segmentation , 2019, MICCAI.

[205]  A.D. Hoover,et al.  Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response , 2000, IEEE Transactions on Medical Imaging.

[206]  Quoc V. Le,et al.  Rethinking Pre-training and Self-training , 2020, NeurIPS.