Frontal lobe connectivity and cognitive impairment in pediatric frontal lobe epilepsy

Purpose:  Cognitive impairment is frequent in children with frontal lobe epilepsy (FLE), but its etiology is unknown. With functional magnetic resonance imaging (fMRI), we have explored the relationship between brain activation, functional connectivity, and cognitive functioning in a cohort of pediatric patients with FLE and healthy controls.

[1]  Andreas Schulze-Bonhage,et al.  Differential effect of side of temporal lobe epilepsy on lateralization of hippocampal, temporolateral, and inferior frontal activation patterns during a verbal episodic memory task , 2008, Epilepsy & Behavior.

[2]  G. Jackson,et al.  Functional connectivity networks are disrupted in left temporal lobe epilepsy , 2006, Annals of neurology.

[3]  John S. Duncan,et al.  Neural correlates of working memory in Temporal Lobe Epilepsy — An fMRI study , 2012, NeuroImage.

[4]  P. Hofman,et al.  Cognitive fMRI and neuropsychological assessment in patients with secondarily generalized seizures , 2008, Clinical Neurology and Neurosurgery.

[5]  John S. Duncan,et al.  Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study , 2011, Brain : a journal of neurology.

[6]  J B Poline,et al.  Episodic memory in left temporal lobe epilepsy: a functional MRI study. , 2000, Brain : a journal of neurology.

[7]  L. Carmant,et al.  Nonlesional Frontal Lobe Epilepsy (FLE) of Childhood: Clinical Presentation, Response to Treatment and Comorbidity , 2006, Epilepsia.

[8]  Q. Gong,et al.  Altered functional connectivity in default mode network in absence epilepsy: A resting‐state fMRI study , 2011, Human brain mapping.

[9]  B M Bly,et al.  An Investigation of Working Memory Rehearsal in Multiple Sclerosis Using fMRI , 2003, Journal of clinical and experimental neuropsychology.

[10]  J. Vannest,et al.  Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy , 2008, Epilepsy & Behavior.

[11]  Katherine Carpenter,et al.  Functional and structural changes in the memory network associated with left temporal lobe epilepsy , 2009, Human brain mapping.

[12]  P. Hofman,et al.  Abnormal modular organization of functional networks in cognitively impaired children with frontal lobe epilepsy. , 2013, Cerebral cortex.

[13]  G Plazzi,et al.  Nocturnal frontal lobe epilepsy. A clinical and polygraphic overview of 100 consecutive cases. , 1999, Brain : a journal of neurology.

[14]  Karl J. Friston,et al.  Unified segmentation , 2005, NeuroImage.

[15]  O. Gruber,et al.  Evaluation of cognition, structural, and functional MRI in juvenile myoclonic epilepsy , 2009, Epilepsia.

[16]  Edward T. Bullmore,et al.  Network-based statistic: Identifying differences in brain networks , 2010, NeuroImage.

[17]  P. Chauvel,et al.  Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms , 2009, Human brain mapping.

[18]  Huafu Chen,et al.  Altered Functional Connectivity and Small-World in Mesial Temporal Lobe Epilepsy , 2010, PloS one.

[19]  Josemir W Sander,et al.  National General Practice Study of Epilepsy (NGPSE) , 1992, Neurology.

[20]  Eric Achten,et al.  Lateralized anterior mesiotemporal lobe activation: semirandom functional MR imaging encoding paradigm in patients with temporal lobe epilepsy--initial experience. , 2005, Radiology.

[21]  Walter H Backes,et al.  Cognitive and behavioural findings in children with frontal lobe epilepsy. , 2012, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[22]  S. Holm A Simple Sequentially Rejective Multiple Test Procedure , 1979 .

[23]  P. Hofman,et al.  Functional connectivity and language impairment in cryptogenic localization-related epilepsy , 2010, Neurology.

[24]  P. Hofman,et al.  Cognitive and behavioral complications of frontal lobe epilepsy in children: A review of the literature , 2011, Epilepsia.

[25]  J. Stretton,et al.  Frontal lobe function in temporal lobe epilepsy , 2012, Epilepsy Research.

[26]  John S Duncan,et al.  Reorganization of Verbal and Nonverbal Memory in Temporal Lobe Epilepsy Due to Unilateral Hippocampal Sclerosis , 2007, Epilepsia.

[27]  Huafu Chen,et al.  Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy , 2010, Brain Research.

[28]  Thomas E. Nichols,et al.  Nonparametric permutation tests for functional neuroimaging: A primer with examples , 2002, Human brain mapping.

[29]  M. Manosevitz,et al.  High-Speed Scanning in Human Memory , 2022 .

[30]  F. Mormann,et al.  Presurgical Language fMRI in Patients with Drug‐resistant Epilepsy: Effects of Task Performance , 2006, Epilepsia.

[31]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .