Design and mechanics of continuum robots for surgery

This dissertation describes design and modeling of two new flexible, continuous backbone robotic dexterity enhancement devices, and algorithms to robotically manipulate them in surgery. These steerable needles and active cannulas provide dexterity in thin (needle-sized) form factors, permitting surgical tools to “turn corners” inside the human body. The robotic tool manipulation algorithms are useful for rapidly and accurately aligning many kinds of surgical tools with planned poses and entry vectors. Drawing on techniques from artificial intelligence, they do not require cumbersome calibration, complete knowledge of robot kinematics, or even encoding, making them well-suited to uncertain real-world clinical environments. Simulations and experimental results demonstrate the accuracy and speed of the algorithms. When an intervention is needle-based, steerable needles provide a means to achieve dexterity within soft tissue after insertion begins. Asymmetric forces generated by a bevel tip are harnessed robotically to generate controllable deflection, and curvature is enhanced by design of needle properties and geometry. The needle is modeled as a nonholonomic system with model parameters fit to experimental data. A new control

[1]  K. S. Arun,et al.  Least-Squares Fitting of Two 3-D Point Sets , 1987, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[2]  Minoru Hashimoto,et al.  Development of electrically heated SMA active forceps for laparoscopic surgery , 1999, Proceedings 1999 IEEE International Conference on Robotics and Automation (Cat. No.99CH36288C).

[3]  Russell H. Taylor,et al.  A Novel Mechanical Transmission Applied to Percutaneous Renal Access , 1997, Dynamic Systems and Control.

[4]  J. Bruce C. Davies,et al.  Continuum robots - a state of the art , 1999, Proceedings 1999 IEEE International Conference on Robotics and Automation (Cat. No.99CH36288C).

[5]  P. Stergiopoulos,et al.  A framework for the haptic rendering of the human hand , 2003, 11th Symposium on Haptic Interfaces for Virtual Environment and Teleoperator Systems, 2003. HAPTICS 2003. Proceedings..

[6]  Ian D. Walker,et al.  Kinematics and the Implementation of an Elephant's Trunk Manipulator and Other Continuum Style Robots , 2003, J. Field Robotics.

[7]  Gregory S. Chirikjian,et al.  Design and experiments with a 30 DOF robot , 1993, [1993] Proceedings IEEE International Conference on Robotics and Automation.

[8]  M. S. Nathan,et al.  The Probot—an active robot for prostate resection , 1997, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[9]  Gregory S. Chirikjian,et al.  Inverse kinematics of discretely actuated hyper-redundant manipulators using workspace densities , 1996, Proceedings of IEEE International Conference on Robotics and Automation.

[10]  Christopher D. Rahn,et al.  Design of Continuous Backbone, Cable-Driven Robots , 2002 .

[11]  Septimiu E. Salcudean,et al.  Needle insertion modeling and simulation , 2003, IEEE Trans. Robotics Autom..

[12]  A Rovetta Tests on reliability of a prostate biopsy telerobotic system. , 1999, Studies in health technology and informatics.

[13]  A. Jemal,et al.  Cancer Statistics, 2004 , 2004, CA: a cancer journal for clinicians.

[14]  Abhilash Pandya,et al.  The application accuracy of the NeuroMate robot--A quantitative comparison with frameless and frame-based surgical localization systems. , 2002, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[15]  広瀬 茂男,et al.  Biologically inspired robots : snake-like locomotors and manipulators , 1993 .

[16]  Gregory S. Chirikjian,et al.  A general numerical method for hyper-redundant manipulator inverse kinematics , 1993, [1993] Proceedings IEEE International Conference on Robotics and Automation.

[17]  Gabor Fichtinger,et al.  Virtual Remote Center of Motion control for needle placement robots , 2003, MICCAI.

[18]  Dominiek Reynaerts,et al.  Design of an advanced tool guiding system for robotic surgery , 2003, 2003 IEEE International Conference on Robotics and Automation (Cat. No.03CH37422).

[20]  Jean-Yves Bouguet,et al.  Camera calibration toolbox for matlab , 2001 .

[21]  Qian Zhang,et al.  Visualization of tumors and metastases in live animals with bacteria and vaccinia virus encoding light-emitting proteins , 2004, Nature Biotechnology.

[22]  Amy E. Kerdok,et al.  A TECHNIQUE FOR MEASURING LOCAL INTERNAL MECHANICAL PROPERTIES OF PERFUSED SOLID ORGANS , 2003 .

[23]  J. Blasko,et al.  Brachytherapy for carcinoma of the prostate: techniques, patient selection, and clinical outcomes. , 2002, Seminars in radiation oncology.

[24]  Emad M. Boctor,et al.  Tracked 3D ultrasound in radio-frequency liver ablation , 2003, SPIE Medical Imaging.

[25]  Russell H. Taylor,et al.  A Perspective on Medical Robotics , 2006, Proceedings of the IEEE.

[26]  Russell H. Taylor,et al.  A Modular Surgical Robotic System for Image Guided Percutaneous Procedures , 1998, MICCAI.

[27]  Gang Wan,et al.  Robot-assisted 3D-TRUS guided prostate brachytherapy: system integration and validation. , 2004, Medical physics.

[28]  Oussama Khatib,et al.  A unified approach for motion and force control of robot manipulators: The operational space formulation , 1987, IEEE J. Robotics Autom..

[29]  T. Fukuda,et al.  Micro active guide wire catheter system-characteristic evaluation, electrical model and operability evaluation of micro active catheter , 1995, MHS'95. Proceedings of the Sixth International Symposium on Micro Machine and Human Science.

[30]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[31]  Russell H. Taylor,et al.  A dexterous system for laryngeal surgery , 2004, IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004.

[32]  C.N. Riviere,et al.  Flexible Needle Steering System for Percutaneous Access to Deep Zones of the Brain , 2006, Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference.

[33]  S. Aramaki,et al.  Tube type micro manipulator using shape memory alloy (SMA) , 1995, MHS'95. Proceedings of the Sixth International Symposium on Micro Machine and Human Science.

[34]  M. Cooperberg,et al.  The changing face of low-risk prostate cancer: trends in clinical presentation and primary management. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[35]  Scott Ulmer,et al.  Hepatocellular carcinoma , 2000, Postgraduate medicine.

[36]  Shoichi Iikura,et al.  Development of flexible microactuator and its applications to robotic mechanisms , 1991, Proceedings. 1991 IEEE International Conference on Robotics and Automation.

[37]  Shuichi Wakimoto,et al.  A miniature inspection robot negotiating pipes of widely varying diameter , 2003, 2003 IEEE International Conference on Robotics and Automation (Cat. No.03CH37422).

[38]  A W Partin,et al.  Bioimpedance: Novel use of a minimally invasive technique for cancer localization in the intact prostate , 1999, The Prostate.

[39]  Peter I. Corke,et al.  A tutorial on visual servo control , 1996, IEEE Trans. Robotics Autom..

[40]  C.N. Riviere,et al.  Toward Effective Needle Steering in Brain Tissue , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[41]  Ian A. Gravagne,et al.  On the structure of minimum effort solutions with application to kinematic redundancy resolution , 2000, IEEE Trans. Robotics Autom..

[42]  Robert J. Webster,et al.  Design Considerations for Robotic Needle Steering , 2005, Proceedings of the 2005 IEEE International Conference on Robotics and Automation.

[43]  D. Stoianovici URobotics--Urology Robotics at Johns Hopkins. , 2001, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[44]  Russell H. Taylor,et al.  Motion constrained control of robots for dexterous surgical tasks , 2008 .

[45]  Kenneth Y. Goldberg,et al.  Constant-Curvature Motion Planning Under Uncertainty with Applications in Image-Guided Medical Needle Steering , 2006, WAFR.

[46]  D. Stoianovici,et al.  Robotic percutaneous access to the kidney: comparison with standard manual access. , 2002, Journal of endourology.

[47]  Gregory S. Chirikjian,et al.  An obstacle avoidance algorithm for hyper-redundant manipulators , 1990, Proceedings., IEEE International Conference on Robotics and Automation.

[48]  P. Gorman,et al.  A prototype haptic lumbar puncture simulator. , 2000, Studies in health technology and informatics.

[49]  Robert Rohling,et al.  Hand-held steerable needle device , 2005 .

[50]  Robert J. Webster,et al.  The Electronic Ball Boy: a reactive visually guided mobile robot for the tennis court , 2002, Proceedings 2002 IEEE International Conference on Robotics and Automation (Cat. No.02CH37292).

[51]  Jin Seob Kim,et al.  Conformational analysis of stiff chiral polymers with end-constraints , 2006, Molecular simulation.

[52]  Gregory S. Chirikjian,et al.  A new inverse kinematics algorithm for binary manipulators with many actuators , 2000 .

[53]  Ken Goldberg,et al.  Simulating needle insertion and radioactive seed implantation for prostate brachytherapy. , 2003, Studies in health technology and informatics.

[54]  Robert J. Webster,et al.  The haptic scissors: cutting in virtual environments , 2003, 2003 IEEE International Conference on Robotics and Automation (Cat. No.03CH37422).

[55]  Adam Morecki,et al.  Elephant trunk type elastic manipulator - a tool for bulk and liquid materials transportation , 1999, Robotica.

[56]  Howie Choset,et al.  A mobile hyper redundant mechanism for search and rescue tasks , 2003, Proceedings 2003 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2003) (Cat. No.03CH37453).

[57]  Gregory S. Chirikjian,et al.  Parallel formulation of the inverse kinematics of modular hyper-redundant manipulators , 1991, Proceedings. 1991 IEEE International Conference on Robotics and Automation.

[58]  Guy Immega,et al.  The KSI tentacle manipulator , 1995, Proceedings of 1995 IEEE International Conference on Robotics and Automation.

[59]  Paolo Dario,et al.  A miniature steerable end-effector for application in an integrated system for computer-assisted arthroscopy , 1997, Proceedings of International Conference on Robotics and Automation.

[60]  Robert J. Webster,et al.  A novel two-dimensional tactile slip display: design, kinematics and perceptual experiments , 2005, TAP.

[61]  P. Gardner,et al.  The Expanded Endonasal Approach: A Fully Endoscopic Transnasal Approach and Resection of the Odontoid Process: Technical Case Report , 2005, Neurosurgery.

[62]  Peter N. Brett,et al.  Schemes for the identification of tissue types and boundaries at the tool point for surgical needles , 2000, IEEE Transactions on Information Technology in Biomedicine.

[63]  Nabil Simaan,et al.  Snake-Like Units Using Flexible Backbones and Actuation Redundancy for Enhanced Miniaturization , 2005, Proceedings of the 2005 IEEE International Conference on Robotics and Automation.

[64]  Allison M. Okamura,et al.  Measurement of the Tip and Friction Force Acting on a Needle during Penetration , 2002, MICCAI.

[65]  E. Nakakura,et al.  Management of hepatocellular carcinoma. , 2000, Oncology.

[66]  Kenneth Y. Goldberg,et al.  Needle insertion and radioactive seed implantation in human tissues: simulation and sensitivity analysis , 2003, 2003 IEEE International Conference on Robotics and Automation (Cat. No.03CH37422).

[67]  Koji Ikuta,et al.  Shape memory alloy servo actuator system with electric resistance feedback and application for active endoscope , 1988, Proceedings. 1988 IEEE International Conference on Robotics and Automation.

[68]  Ian A. Gravagne,et al.  Manipulability, force, and compliance analysis for planar continuum manipulators , 2002, IEEE Trans. Robotics Autom..

[69]  R. Colton,et al.  Endoscopic microsuture repair of vocal fold defects. , 1995, Journal of voice : official journal of the Voice Foundation.

[70]  B L Davies,et al.  The Development of a Surgeon Robot for Prostatectomies , 1991, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[71]  Gregory S. Chirikjian,et al.  Novel Algorithms for Robust Registration of Fiducials in CT and MRI , 2001, MICCAI.

[72]  Allison M. Okamura,et al.  Robotic needle insertion: effects of friction and needle geometry , 2003, 2003 IEEE International Conference on Robotics and Automation (Cat. No.03CH37422).

[73]  Toshikatsu Washio,et al.  A Model for Relations between Needle Deflection, Force, and Thickness on Needle Penetration , 2001, MICCAI.

[74]  T. Varma,et al.  Use of the NeuroMate Stereotactic Robot in a Frameless Mode for Movement Disorder Surgery , 2004, Stereotactic and Functional Neurosurgery.

[75]  Jin Seob Kim,et al.  Nonholonomic Modeling of Needle Steering , 2006, Int. J. Robotics Res..

[76]  C. B. Simpson,et al.  Comparison of Microflap Healing Outcomes with Traditional and Microsuturing Techniques: Initial Results in a Canine Model , 2001, The Annals of otology, rhinology, and laryngology.

[77]  T. A. Thomas,et al.  Simulation of resistance forces acting on surgical needles , 1997, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[78]  Russell H. Taylor,et al.  Robotically assisted ablative treatment guided by freehand 3D ultrasound , 2004, CARS.

[79]  Jin Seob Kim,et al.  Diffusion-Based Motion Planning for a Nonholonomic Flexible Needle Model , 2005, Proceedings of the 2005 IEEE International Conference on Robotics and Automation.

[80]  Michael A. Peshkin,et al.  A general framework for cobot control , 2001, IEEE Trans. Robotics Autom..

[81]  Margrit Betke,et al.  Learning and vision algorithms for robot navigation , 1995 .

[82]  A. Darzi,et al.  Relationship between skill and outcome in the laboratory-based model. , 2002, Surgery.

[83]  I. Kassim,et al.  Locomotion techniques for robotic colonoscopy , 2006, IEEE Engineering in Medicine and Biology Magazine.

[84]  Jonghoon Park,et al.  Geometric integration on Euclidean group with application to articulated multibody systems , 2005, IEEE Transactions on Robotics.

[85]  Shahram Payandeh,et al.  Synthesis and Workspace Study of Endoscopic Extenders With Flexible Stem , 1997 .

[86]  Han-Wen Nienhuys,et al.  A Surgery Simulation Supporting Cuts and Finite Element Deformation , 2001, MICCAI.

[87]  Koichi Suzumori,et al.  The development of an in-pipe microrobot applying the motion of an earthworm , 1994, 1994 5th International Symposium on Micro Machine and Human Science Proceedings.

[88]  Thierry Siméon,et al.  The Stochastic Motion Roadmap: A Sampling Framework for Planning with Markov Motion Uncertainty , 2007, Robotics: Science and Systems.

[89]  Brian Mirtich,et al.  A Survey of Deformable Modeling in Computer Graphics , 1997 .

[90]  Robert J. Webster,et al.  Kinematics and calibration of active cannulas , 2008, 2008 IEEE International Conference on Robotics and Automation.

[91]  Gregory S. Chirikjian,et al.  Theory and applications of hyper-redundant robotic manipulators , 1992 .

[92]  Timothy Ohm,et al.  The JPL Serpentine Robot: a 12-DOF system for inspection , 1995, Proceedings of 1995 IEEE International Conference on Robotics and Automation.

[93]  B L Davies,et al.  Locomotion and steering aspects in automation of colonoscopy. Part one.A literature review. , 1997, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[94]  Yoshihiko Nakamura,et al.  Shape-memory-alloy active forceps for laparoscopic surgery , 1995, Proceedings of 1995 IEEE International Conference on Robotics and Automation.

[95]  Don Stredney,et al.  A physiologically valid simulator for training residents to perform an epidural block , 1996, Proceedings of the 1996 Fifteenth Southern Biomedical Engineering Conference.

[96]  Robert D. Howe,et al.  Port placement planning in robot-assisted coronary artery bypass , 2003, IEEE Trans. Robotics Autom..

[97]  Rajni V. Patel,et al.  Minimization of needle deflection in robot‐assisted percutaneous therapy , 2007, The international journal of medical robotics + computer assisted surgery : MRCAS.

[98]  Septimiu E. Salcudean,et al.  Needle Steering and Model-Based Trajectory Planning , 2003, MICCAI.

[99]  Allison M. Okamura,et al.  Planning for Steerable Bevel-tip Needle Insertion Through 2D Soft Tissue with Obstacles , 2005, Proceedings of the 2005 IEEE International Conference on Robotics and Automation.

[100]  J. Burdick,et al.  A Modal Approach to Hyper-Redundant , 1994 .

[101]  Russell H. Taylor,et al.  High Dexterity Snake-Like Robotic Slaves for Minimally Invasive Telesurgery of the Upper Airway , 2004, MICCAI.

[102]  Vinutha Kallem,et al.  Task-induced symmetry and reduction in kinematic systems with application to needle steering , 2007, 2007 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[103]  R Bruce,et al.  CT-integrated robot for interventional procedures: preliminary experiment and computer-human interfaces. , 2001, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[104]  Nassir Navab,et al.  A New Robotic System for Visually Controlled Percutaneous Inerventions under CT Fluoroscopy , 2000, MICCAI.

[105]  S. Mulier,et al.  Size and geometry of hepatic radiofrequency lesions. , 2003, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[106]  John Kenneth Salisbury,et al.  The Intuitive/sup TM/ telesurgery system: overview and application , 2000, Proceedings 2000 ICRA. Millennium Conference. IEEE International Conference on Robotics and Automation. Symposia Proceedings (Cat. No.00CH37065).

[107]  T. Vo‐Dinh,et al.  Biosensors and biochips: advances in biological and medical diagnostics , 2000, Fresenius' journal of analytical chemistry.

[108]  Emanuel Slawiñski,et al.  Bilateral teleoperation of mobile robots , 2002, Robotica.

[109]  Gregory S. Chirikjian,et al.  Hyper-redundant manipulator dynamics: a continuum approximation , 1994, Adv. Robotics.

[110]  Kenneth Y. Goldberg,et al.  Sensorless planning for medical needle insertion procedures , 2003, Proceedings 2003 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2003) (Cat. No.03CH37453).

[111]  Bruce Randall Donald,et al.  A Search Algorithm for Motion Planning with Six Degrees of Freedom , 1987, Artif. Intell..

[112]  Russell H. Taylor,et al.  A telerobotic assistant for laparoscopic surgery , 1995 .

[113]  J.-G.S. Demers,et al.  Freedom 6S Force Feedback Hand Controller , 1998 .

[114]  Yasushi Wakahara,et al.  A computer-aided manipulation system for a multijoint inspection robot , 1984 .

[115]  Han-Wen Nienhuys,et al.  A computational technique for interactive needle insertions in 3D nonlinear material , 2004, IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004.

[116]  D. Stoianovici,et al.  Robotically driven interventions: a method of using CT fluoroscopy without radiation exposure to the physician. , 2002, Radiology.

[117]  Allison M. Okamura,et al.  Virtual fixtures for bilateral telemanipulation , 2006 .

[118]  Ronald S Boris,et al.  Radical prostatectomy: a single surgeon comparison of retropubic, perineal, and robotic approaches. , 2007, The Canadian journal of urology.

[119]  Russell H. Taylor,et al.  Medical robotics in computer-integrated surgery , 2003, IEEE Trans. Robotics Autom..

[120]  Ève Coste-Manière,et al.  Optimal planning for minimally invasive surgical robots , 2003, IEEE Trans. Robotics Autom..

[121]  Makoto Kaneko,et al.  Co-axis type non-contact impedance sensor , 2004, IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004.

[122]  Ian D. Walker,et al.  Practical Kinematics for Real-Time Implementation of Continuum Robots , 2006, IEEE Transactions on Robotics.

[123]  Frank Tendick,et al.  Workspace analysis of robotic manipulators for a teleoperated suturing task , 2001, Proceedings 2001 IEEE/RSJ International Conference on Intelligent Robots and Systems. Expanding the Societal Role of Robotics in the the Next Millennium (Cat. No.01CH37180).

[124]  S. Mayer Ultra-Early Hemostatic Therapy for Intracerebral Hemorrhage , 2003, Stroke.

[125]  P. Kazanzides,et al.  A System for Speed and Torque Control of DC Motors with Application to Small Snake Robots , 2004 .

[126]  Paolo Dario,et al.  Design of a Pill-Sized 12-legged Endoscopic Capsule Robot , 2007, Proceedings 2007 IEEE International Conference on Robotics and Automation.

[127]  Wei Wei,et al.  A Compact Two-armed Slave Manipulator for Minimally Invasive Surgery of the Throat , 2006, The First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006. BioRob 2006..

[128]  Gregory S. Chirikjian,et al.  Kinematic Synthesis of Mechanisms and Robotic Manipulators With Binary Actuators , 1995 .

[129]  Robert J. Webster,et al.  Teleoperation of Steerable Needles , 2007, Proceedings 2007 IEEE International Conference on Robotics and Automation.

[130]  Gregory S. Chirikjian,et al.  Kinematically optimal hyper-redundant manipulator configurations , 1995, IEEE Trans. Robotics Autom..

[131]  Allison M. Okamura,et al.  Stable Forbidden-Region Virtual Fixtures for Bilateral Telemanipulation , 2006 .

[132]  Shigeo Hirose,et al.  Biologically Inspired Robots , 1993 .

[133]  Ian D. Walker,et al.  Real-time shape estimation for continuum robots using vision , 2005, Robotica.

[134]  Ian D. Walker,et al.  Kinematics for multisection continuum robots , 2006, IEEE Transactions on Robotics.

[135]  Daniel Glozman,et al.  Flexible Needle Steering and Optimal Trajectory Planning for Percutaneous Therapies , 2004, MICCAI.

[136]  Vinutha Kallem,et al.  Image-guided Control of Flexible Bevel-Tip Needles , 2007, Proceedings 2007 IEEE International Conference on Robotics and Automation.

[137]  Ken Masamune,et al.  System for robotically assisted prostate biopsy and therapy with intraoperative CT guidance. , 2002, Academic radiology.

[138]  John J. Craig Zhu,et al.  Introduction to robotics mechanics and control , 1991 .

[139]  Paolo Dario,et al.  Analysis and development of locomotion devices for the gastrointestinal tract , 2002, IEEE Transactions on Biomedical Engineering.

[140]  Kai Xu,et al.  Actuation compensation for flexible surgical snake-like robots with redundant remote actuation , 2006, Proceedings 2006 IEEE International Conference on Robotics and Automation, 2006. ICRA 2006..

[141]  Ian D. Walker,et al.  Design, analysis and experimentation: the fundamentals of continuum robotic manipulators , 2002 .

[142]  Septimiu E. Salcudean,et al.  Interactive simulation of needle insertion models , 2005, IEEE Transactions on Biomedical Engineering.

[143]  Gregory S. Chirikjian,et al.  Steering flexible needles under Markov motion uncertainty , 2005, 2005 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[144]  A. Kapoor,et al.  Suturing in confined spaces: constrained motion control of a hybrid 8-DoF robot , 2005, ICAR '05. Proceedings., 12th International Conference on Advanced Robotics, 2005..

[145]  Allison M. Okamura,et al.  Methods for haptic feedback in teleoperated robot-assisted surgery , 2004 .

[146]  Shugen Ma,et al.  Coupled tendon-driven multijoint manipulator , 1991, Proceedings. 1991 IEEE International Conference on Robotics and Automation.

[147]  Ian A. Gravagne,et al.  Kinematic transformations for remotely-actuated planar continuum robots , 2000, Proceedings 2000 ICRA. Millennium Conference. IEEE International Conference on Robotics and Automation. Symposia Proceedings (Cat. No.00CH37065).

[148]  Ian D. Walker,et al.  A novel 'elephant's trunk' robot , 1999, 1999 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (Cat. No.99TH8399).

[149]  Ian D. Walker,et al.  Large deflection dynamics and control for planar continuum robots , 2001 .

[150]  Y. Haga,et al.  Small diameter active catheter using shape memory alloy , 1998, Proceedings MEMS 98. IEEE. Eleventh Annual International Workshop on Micro Electro Mechanical Systems. An Investigation of Micro Structures, Sensors, Actuators, Machines and Systems (Cat. No.98CH36176.

[151]  Junji Furusho,et al.  Curved multi‐tube device for path‐error correction in a needle‐insertion system , 2007, The international journal of medical robotics + computer assisted surgery : MRCAS.

[152]  F Tendick,et al.  Measuring in vivo animal soft tissue properties for haptic modeling in surgical simulation. , 2001, Studies in health technology and informatics.

[153]  S. Hayati,et al.  A robot with improved absolute positioning accuracy for CT guided stereotactic brain surgery , 1988, IEEE Transactions on Biomedical Engineering.

[154]  Maria Chiara Carrozza,et al.  A novel mechatronic tool for computer-assisted arthroscopy , 2000, IEEE Transactions on Information Technology in Biomedicine.

[155]  Ping-Lang Yen,et al.  A Telemanipulator system as an assistant and training tool for penetrating soft tissue , 1996 .

[156]  Pierre E. Dupont,et al.  A Steerable Needle Technology Using Curved Concentric Tubes , 2006, 2006 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[157]  Daniel Glozman,et al.  Image-Guided Robotic Flexible Needle Steering , 2007, IEEE Transactions on Robotics.

[158]  H. Choset,et al.  Percutaneous Intrapericardial Interventions Using a Highly Articulated Robotic Probe , 2006, The First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006. BioRob 2006..

[159]  Richard M. Murray,et al.  A Mathematical Introduction to Robotic Manipulation , 1994 .

[160]  阿部 博之,et al.  Data book on mechanical properties of living cells, tissues, and organs , 1996 .

[161]  C. Snyderman,et al.  Transnasal Endoscopic Repair of Cerebrospinal Fluid Rhinorrhea: A Meta‐Analysis , 2000, The Laryngoscope.

[162]  Wei Wei,et al.  Design and Theoretical Evaluation of Micro-Surgical Manipulators for Orbital Manipulation and Intraocular Dexterity , 2007, Proceedings 2007 IEEE International Conference on Robotics and Automation.

[163]  G. Lim,et al.  Future of active catheters , 1996 .

[164]  Koichi Osuka,et al.  Development of mobile inspection robot for rescue activities: MOIRA , 2003, Proceedings 2003 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2003) (Cat. No.03CH37453).

[165]  R. Ohta Results of R&D on catheter-type micromachine , 2001, MHS2001. Proceedings of 2001 International Symposium on Micromechatronics and Human Science (Cat. No.01TH8583).

[166]  Rod J. Rohrich,et al.  Rationale for submucous resection of hypertrophied inferior turbinates in rhinoplasty: an evolution. , 2001, Plastic and reconstructive surgery.

[167]  Russell H. Taylor,et al.  A dual-armed robotic system for intraoperative ultrasound guided hepatic ablative therapy: a prospective study , 2004, IEEE International Conference on Robotics and Automation, 2004. Proceedings. ICRA '04. 2004.

[168]  Robert J. Webster,et al.  Toward Active Cannulas: Miniature Snake-Like Surgical Robots , 2006, 2006 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[169]  Pierre E. Dupont,et al.  Inverse Kinematics of Concentric Tube Steerable Needles , 2007, Proceedings 2007 IEEE International Conference on Robotics and Automation.