Remembering Preservation in Hippocampal Amnesia.

The lesion-deficit model dominates neuropsychology. This is unsurprising given powerful demonstrations that focal brain lesions can affect specific aspects of cognition. Nowhere is this more evident than in patients with bilateral hippocampal damage. In the past 60 years, the amnesia and other impairments exhibited by these patients have helped to delineate the functions of the hippocampus and shape the field of memory. We do not question the value of this approach. However, less prominent are the cognitive processes that remain intact following hippocampal lesions. Here, we collate the piecemeal reports of preservation of function following focal bilateral hippocampal damage, highlighting a wealth of information often veiled by the field's focus on deficits. We consider how a systematic understanding of what is preserved as well as what is lost could add an important layer of precision to models of memory and the hippocampus.

[1]  W. Scoville,et al.  LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS , 1957, Journal of neurology, neurosurgery, and psychiatry.

[2]  M. Gluck,et al.  Intact delay-eyeblink classical conditioning in amnesia. , 1995, Behavioral neuroscience.

[3]  A. Parkin,et al.  Attention and recollective experience in recognition memory , 1990, Memory & cognition.

[4]  Richard S. J. Frackowiak,et al.  Knowing where and getting there: a human navigation network. , 1998, Science.

[5]  Charan Ranganath,et al.  Opinion TRENDS in Cognitive Sciences Vol.9 No.8 August 2005 Doubts about double dissociations between short- and long-term memory , 2022 .

[6]  N. Roberts,et al.  Differential involvement of the hippocampus and temporal lobe cortices in rapid and slow learning of new semantic information , 2002, Neuropsychologia.

[7]  J. Aggleton,et al.  Anterior thalamic lesions stop immediate early gene activation in selective laminae of the retrosplenial cortex: evidence of covert pathology in rats? , 2004, The European journal of neuroscience.

[8]  E. Maguire,et al.  Constructing, Perceiving, and Maintaining Scenes: Hippocampal Activity and Connectivity , 2014, Cerebral cortex.

[9]  E. Tulving.  Memory and consciousness. , 1985 .

[10]  Adam N Mamelak,et al.  Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task , 2002, Behavioural Brain Research.

[11]  G. Winocur,et al.  Memory Transformation and Systems Consolidation , 2011, Journal of the International Neuropsychological Society.

[12]  D. Hassabis,et al.  Patients with hippocampal amnesia cannot imagine new experiences , 2007, Proceedings of the National Academy of Sciences.

[13]  J. Winer,et al.  Autoimmune limbic encephalitis causing fits, rapidly progressive confusion and hyponatraemia. , 2006, Age and ageing.

[14]  E. D. Haan,et al.  Varieties of human spatial memory: a meta-analysis on the effects of hippocampal lesions , 2001, Brain Research Reviews.

[15]  Suzanne Corkin,et al.  ACQUISITION OF MOTOR SKILL AFTER BILATERAL MEDIAL TEMPORAL-LOBE EXCISION , 1968 .

[16]  Eleanor A. Maguire,et al.  Decoding information in the human hippocampus: A user's guide , 2012, Neuropsychologia.

[17]  H. Eichenbaum,et al.  Can We Reconcile the Declarative Memory and Spatial Navigation Views on Hippocampal Function? , 2014, Neuron.

[18]  Andy C. H. Lee,et al.  Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint , 2009, Hippocampus.

[19]  Ellen M. Migo,et al.  Associative memory and the medial temporal lobes , 2007, Trends in Cognitive Sciences.

[20]  D G Gadian,et al.  Amnesia and the organization of the hippocampal system , 1998, Hippocampus.

[21]  D. Schacter,et al.  On the nature of medial temporal lobe contributions to the constructive simulation of future events , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[22]  Doris Y. Tsao,et al.  Mechanisms of face perception. , 2008, Annual review of neuroscience.

[23]  F. Bartlett,et al.  Remembering: A Study in Experimental and Social Psychology , 1932 .

[24]  Eleanor A Maguire,et al.  Lateral Asymmetry in the Hippocampal Response to the Remoteness of Autobiographical Memories , 2003, The Journal of Neuroscience.

[25]  M. Moser,et al.  Functional differentiation in the hippocampus , 1998, Hippocampus.

[26]  Richard S. J. Frackowiak,et al.  Navigation-related structural change in the hippocampi of taxi drivers. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Karl J. Friston,et al.  Developmental amnesia: Effect of age at injury , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[28]  L. Squire,et al.  The cognitive neuroscience of human memory since H.M. , 2011, Annual review of neuroscience.

[29]  L R Squire,et al.  Retrograde Amnesia for Facts and Events: Findings from Four New Cases , 1998, The Journal of Neuroscience.

[30]  M. Gluck,et al.  Impaired probabilistic category learning in hypoxic subjects with hippocampal damage , 2004, Neuropsychologia.

[31]  T. Hubbard,et al.  Boundary extension: Findings and theories , 2010, Quarterly journal of experimental psychology.

[32]  D L Schacter,et al.  Preserved learning in amnesic patients: perspectives from research on direct priming. , 1986, Journal of clinical and experimental neuropsychology.

[33]  N. Cohen,et al.  Relational Memory and the Hippocampus: Representations and Methods , 2009, Front. Neurosci..

[34]  J. Aggleton,et al.  Amnesia and recognition memory: A re-analysis of psychometric data , 1996, Neuropsychologia.

[35]  Susan Carey,et al.  Acquiring a Single New Word , 1978 .

[36]  Ingrid R. Olson,et al.  Working Memory for Conjunctions Relies on the Medial Temporal Lobe , 2006, The Journal of Neuroscience.

[37]  D. Schacter,et al.  Implicit memory: a selective review. , 1993, Annual review of neuroscience.

[38]  Endel Tulving,et al.  Encoding specificity and retrieval processes in episodic memory. , 1973 .

[39]  Morgan D. Barense,et al.  The human medial temporal lobe processes online representations of complex objects , 2007, Neuropsychologia.

[40]  Eleanor A. Maguire,et al.  Thoughts, behaviour, and brain dynamics during navigation in the real world , 2006, NeuroImage.

[41]  H. Eichenbaum,et al.  Hippocampal “Time Cells” Bridge the Gap in Memory for Discontiguous Events , 2011, Neuron.

[42]  Brian Levine,et al.  Theory of Mind Is Independent of Episodic Memory , 2007, Science.

[43]  Helene Intraub,et al.  Surface construal and the mental representation of scenes. , 2002, Journal of experimental psychology. Human perception and performance.

[44]  J. Kihlstrom,et al.  THE EFFECTS OF EPISODIC MEMORY LOSS ON AN AMNESIC PATIENT ’ S ABILITY TO REMEMBER THE PAST AND IMAGINE THE FUTURE , 2003 .

[45]  Neil Burgess,et al.  The hippocampus and spatial constraints on mental imagery , 2012, Front. Hum. Neurosci..

[46]  G. Winocur,et al.  Remembering our past: functional neuroanatomy of recollection of recent and very remote personal events. , 2004, Cerebral cortex.

[47]  Orna Aizenstein,et al.  Bilateral hippocampal lesion and a selective impairment of the ability for mental time travel , 2010, Neurocase.

[48]  Andy C. H. Lee,et al.  Abnormal Categorization and Perceptual Learning in Patients with Hippocampal Damage , 2006, The Journal of Neuroscience.

[49]  E. Tulving,et al.  Consciousness of subjective time in the brain , 2010, Proceedings of the National Academy of Sciences.

[50]  D. Salat,et al.  Default Network Connectivity in Medial Temporal Lobe Amnesia , 2012, The Journal of Neuroscience.

[51]  Jing Wang,et al.  Decoding abstract and concrete concept representations based on single‐trial fMRI data , 2013, Human brain mapping.

[52]  L R Squire,et al.  Dissociable properties of memory systems: differences in the flexibility of declarative and nondeclarative knowledge. , 1996, Behavioral neuroscience.

[53]  C. Brock Kirwan,et al.  Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe , 2008, Proceedings of the National Academy of Sciences.

[54]  Demis Hassabis,et al.  The construction system of the brain , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[55]  E. Maguire,et al.  Newcastle University Eprints , 2022 .

[56]  David A. Medler,et al.  Distinct Brain Systems for Processing Concrete and Abstract Concepts , 2005, Journal of Cognitive Neuroscience.

[57]  T. Shallice,et al.  Long-term retrograde amnesia… the crucial role of the hippocampus , 2001, Neuropsychologia.

[58]  Kim Kirsner,et al.  What Can we Infer from Double Dissociations? , 2003, Cortex.

[59]  C. Ranganath.  A unified framework for the functional organization of the medial temporal lobes and the phenomenology of episodic memory , 2010, Hippocampus.

[60]  N. Roberts,et al.  Item recognition is less impaired than recall and associative recognition in a patient with selective hippocampal damage , 2005, Hippocampus.

[61]  J. Aggleton,et al.  A comparison of egocentric and allocentric spatial memory in a patient with selective hippocampal damage , 2000, Neuropsychologia.

[62]  R. Malach,et al.  Early ‘visual’ cortex activation correlates with superior verbal memory performance in the blind , 2003, Nature Neuroscience.

[63]  J. Rawlins,et al.  Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. , 2004, Behavioral neuroscience.

[64]  N. Burgess,et al.  The Hippocampus Supports Recognition Memory for Familiar Words but Not Unfamiliar Faces , 2008, Current Biology.

[65]  A. Yonelinas.  The hippocampus supports high-resolution binding in the service of perception, working memory and long-term memory , 2013, Behavioural Brain Research.

[66]  L. Nadel,et al.  Memory consolidation, retrograde amnesia and the hippocampal complex , 1997, Current Opinion in Neurobiology.

[67]  Eleanor A Maguire,et al.  Counterfactual thinking in patients with amnesia , 2014, Hippocampus.

[68]  Hong-wei Dong,et al.  Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures? , 2010, Neuron.

[69]  R. S. Rosenbaum,et al.  Individuals with episodic amnesia are not stuck in time , 2014, Neuropsychologia.

[70]  L. Squire,et al.  Perceptual learning, awareness, and the hippocampus , 2001, Hippocampus.

[71]  E. Maguire,et al.  Attenuated Boundary Extension Produces a Paradoxical Memory Advantage in Amnesic Patients , 2012, Current Biology.

[72]  A. Yonelinas.  The Nature of Recollection and Familiarity: A Review of 30 Years of Research , 2002 .

[73]  G. Buzsáki,et al.  Memory, navigation and theta rhythm in the hippocampal-entorhinal system , 2013, Nature Neuroscience.

[74]  D. Schacter,et al.  Episodic future thinking and episodic counterfactual thinking: Intersections between memory and decisions , 2015, Neurobiology of Learning and Memory.

[75]  John S. Allen,et al.  Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia. , 2018, Neuropsychology.

[76]  M. Chun,et al.  Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage , 1999, Nature Neuroscience.

[77]  Andy C. H. Lee,et al.  Activating the medial temporal lobe during oddity judgment for faces and scenes. , 2008, Cerebral cortex.

[78]  D. Kieras.  Beyond pictures and words: Alternative information-processing models for imagery effect in verbal memory , 1978 .

[79]  C. Aberson,et al.  Interpreting Null Results: Improving Presentation and Conclusions with Confidence Intervals , 2022 .

[80]  Richard N. A. Henson,et al.  Recognition memory for faces and scenes in amnesia: Dissociable roles of medial temporal lobe structures , 2007, Neuropsychologia.

[81]  A. Paivio.  Mental imagery in associative learning and memory , 1969 .

[82]  G. Winocur,et al.  The cognitive neuroscience of remote episodic, semantic and spatial memory , 2006, Current Opinion in Neurobiology.

[83]  S. Corkin,et al.  H.M.'s contributions to neuroscience: A review and autopsy studies , 2014, Hippocampus.

[84]  M. Mishkin,et al.  The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval. , 2001, Brain : a journal of neurology.

[85]  Neal J Cohen,et al.  The hippocampus uses information just encountered to guide efficient ongoing behavior , 2014, Hippocampus.

[86]  L. Green,et al.  An Allais paradox without mental time travel , 2014, Hippocampus.

[87]  David E. Warren,et al.  Hippocampal Amnesia Impairs All Manner of Relational Memory , 2008, Frontiers in human neuroscience.

[88]  V. Ramachandran,et al.  The Paradoxical Brain: Index , 2011 .

[89]  E. Lein,et al.  Functional organization of the hippocampal longitudinal axis , 2014, Nature Reviews Neuroscience.

[90]  L. Green,et al.  Future decision‐making without episodic mental time travel , 2012, Hippocampus.

[91]  E A Maguire,et al.  Hippocampal Amnesia , 2001, Neurocase.

[92]  C. Good,et al.  HISTOPATHOLOGY OF VGKC ANTIBODY–ASSOCIATED LIMBIC ENCEPHALITIS , 2009, Neurology.

[93]  D Marr,et al.  Simple memory: a theory for archicortex. , 1971, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[94]  Marilyn Jones-Gotman,et al.  Incidental Learning of Image-Mediated or Pronounced Words after Right Temporal Lobectomy , 1979, Cortex.

[95]  Anjan Chatterjee,et al.  Visual Working Memory Is Impaired when the Medial Temporal Lobe Is Damaged , 2006, Journal of Cognitive Neuroscience.

[96]  Avi Karni,et al.  Neocortical catastrophic interference in healthy and amnesic adults: A paradoxical matter of time , 2014, Hippocampus.

[97]  Arvind Caprihan,et al.  Same task, different strategies: How brain networks can be influenced by memory strategy , 2014, Human brain mapping.

[98]  Daniel L. Schacter,et al.  Episodic simulation and episodic memory can increase intentions to help others , 2014, Proceedings of the National Academy of Sciences.

[99]  E Tulving,et al.  Priming and human memory systems. , 1990, Science.

[100]  Demis Hassabis,et al.  Impaired spatial and non-spatial configural learning in patients with hippocampal pathology , 2007, Neuropsychologia.

[101]  D. Schacter,et al.  The cognitive neuroscience of constructive memory. , 1998, Annual review of psychology.

[102]  E. Maguire,et al.  Acquiring “the Knowledge” of London's Layout Drives Structural Brain Changes , 2011, Current Biology.

[103]  Kane W. Elfman,et al.  Neurocomputational account of memory and perception: Thresholded and graded signals in the hippocampus , 2014, Hippocampus.

[104]  L. Squire,et al.  The medial temporal lobe memory system , 1991, Science.

[105]  Neal J. Cohen,et al.  The Long and the Short of It: Relational Memory Impairments in Amnesia, Even at Short Lags , 2006, The Journal of Neuroscience.

[106]  Andy C. H. Lee,et al.  Specialization in the medial temporal lobe for processing of objects and scenes , 2005, Hippocampus.

[107]  Demis Hassabis,et al.  Role of the hippocampus in imagination and future thinking , 2011, Proceedings of the National Academy of Sciences.

[108]  R. Rosenthal.  The file drawer problem and tolerance for null results , 1979 .

[109]  Nikolaus Weiskopf,et al.  Detecting Representations of Recent and Remote Autobiographical Memories in vmPFC and Hippocampus , 2012, The Journal of Neuroscience.

[110]  Demis Hassabis,et al.  Imagining fictitious and future experiences: Evidence from developmental amnesia , 2010, Neuropsychologia.

[111]  G. Poirier,et al.  Post-surgical interval and lesion location within the limbic thalamus determine extent of retrosplenial cortex immediate-early gene hypoactivity , 2009, Neuroscience.

[112]  Yael Shrager,et al.  Intact Visual Perception in Memory-Impaired Patients with Medial Temporal Lobe Lesions , 2006, The Journal of Neuroscience.

[113]  H. Karnath,et al.  Using human brain lesions to infer function: a relic from a past era in the fMRI age? , 2004, Nature Reviews Neuroscience.

[114]  Neal J Cohen,et al.  Development of shared information in communication despite hippocampal amnesia , 2006, Nature Neuroscience.

[115]  Justin S. Feinstein,et al.  Sustained experience of emotion after loss of memory in patients with amnesia , 2010, Proceedings of the National Academy of Sciences.

[116]  Daniel L. Schacter,et al.  The ghosts of past and future: A memory that works by piecing together bits of the past may be better suited to simulating future events than one that is a store of perfect records. , 2007 .

[117]  H. Eichenbaum,et al.  The medial temporal lobe and recognition memory. , 2007, Annual review of neuroscience.

[118]  M Moscovitch,et al.  Hippocampal complex and retrieval of recent and very remote autobiographical memories: Evidence from functional magnetic resonance imaging in neurologically intact people , 2001, Hippocampus.

[119]  R. Skelton,et al.  Spatial deficits in a virtual water maze in amnesic participants with hippocampal damage , 2009, Hippocampus.

[120]  Jennifer A. Mangels,et al.  A Neostriatal Habit Learning System in Humans , 1996, Science.

[121]  P. Reber.  The neural basis of implicit learning and memory: A review of neuropsychological and neuroimaging research , 2013, Neuropsychologia.

[122]  D. Hassabis,et al.  Autobiographical memory in semantic dementia: A longitudinal fMRI study , 2010, Neuropsychologia.

[123]  E. Tulving,et al.  Episodic and semantic memory , 1972 .

[124]  M. Conway,et al.  The construction of autobiographical memories in the self-memory system. , 2000, Psychological review.

[125]  L. Squire,et al.  Memory, scene construction, and the human hippocampus , 2015, Proceedings of the National Academy of Sciences.

[126]  M J West,et al.  Stereological studies of the hippocampus: a comparison of the hippocampal subdivisions of diverse species including hedgehogs, laboratory rodents, wild mice and men. , 1990, Progress in brain research.

[127]  Hallvard Røe Evensmoen,et al.  Long-axis specialization of the human hippocampus , 2013, Trends in Cognitive Sciences.

[128]  N. Cashdollar,et al.  Hippocampus-dependent and -independent theta-networks of active maintenance , 2009, Proceedings of the National Academy of Sciences.

[129]  Brenda Milner,et al.  Right temporal-lobe contribution to image-mediated verbal learning , 1978, Neuropsychologia.

[130]  Eleanor A Maguire,et al.  Representations of recent and remote autobiographical memories in hippocampal subfields , 2013, Hippocampus.

[131]  R. Hopkins,et al.  Word memory test performance in amnesic patients with hippocampal damage. , 2009, Neuropsychology.

[132]  Suzanne Corkin,et al.  Tactually-guided maze learning in man: Effects of unilateral cortical excisions and bilateral hippocampal lesions ☆ , 1965 .

[133]  John T Wixted,et al.  A demonstration that the hippocampus supports both recollection and familiarity , 2009, Proceedings of the National Academy of Sciences.

[134]  M. Verfaellie,et al.  Losing sight of the future: Impaired semantic prospection following medial temporal lobe lesions , 2013, Hippocampus.

[135]  Ramona O Hopkins,et al.  Item memory, source memory, and the medial temporal lobe: concordant findings from fMRI and memory-impaired patients. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[136]  Daphna Shohamy,et al.  Distinct Hippocampal and Basal Ganglia Contributions to Probabilistic Learning and Reversal , 2009, Journal of Cognitive Neuroscience.

[137]  Hanna Damasio,et al.  The scope of preserved procedural memory in amnesia. , 2004, Brain : a journal of neurology.

[138]  Daphna Shohamy,et al.  Strategies in probabilistic categorization: results from a new way of analyzing performance. , 2006, Learning & memory.

[139]  E. Maguire,et al.  The hippocampus extrapolates beyond the view in scenes: An fMRI study of boundary extension , 2013, Cortex.

[140]  Mieke Verfaellie,et al.  Medial Temporal Lobe Damage Causes Deficits in Episodic Memory and Episodic Future Thinking Not Attributable to Deficits in Narrative Construction , 2011, The Journal of Neuroscience.

[141]  Malcolm W. Brown,et al.  Recognition memory: What are the roles of the perirhinal cortex and hippocampus? , 2001, Nature Reviews Neuroscience.

[142]  Ramona O Hopkins,et al.  Visual discrimination performance, memory, and medial temporal lobe function , 2012, Proceedings of the National Academy of Sciences.

[143]  E. Tulving,et al.  Episodic and declarative memory: Role of the hippocampus , 1998, Hippocampus.

[144]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[145]  Daniel L. Schacter,et al.  The case of K.C.: contributions of a memory-impaired person to memory theory , 2005, Neuropsychologia.

[146]  Eleanor A. Maguire,et al.  Scene construction in developmental amnesia: An fMRI study , 2014, Neuropsychologia.

[147]  Larry R. Squire,et al.  Memory for places learned long ago is intact after hippocampal damage , 1999, Nature.

[148]  Dominik R. Bach,et al.  Human Hippocampus Arbitrates Approach-Avoidance Conflict , 2014, Current Biology.

[149]  Kate E Decleene,et al.  Publication Manual of the American Psychological Association , 2011 .

[150]  Tim Shallice,et al.  Recollection and familiarity in dense hippocampal amnesia: A case study , 2006, Neuropsychologia.

[151]  Karl J. Friston,et al.  Remote Effects of Hippocampal Sclerosis on Effective Connectivity during Working Memory Encoding: A Case of Connectional Diaschisis? , 2012, Cerebral cortex.

[152]  R. Adolphs,et al.  Emotional Autobiographical Memories in Amnesic Patients with Medial Temporal Lobe Damage , 2005, The Journal of Neuroscience.

[153]  L. Squire,et al.  Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[154]  M. Victor,et al.  Amnesia due to Lesions Confined to the Hippocampus: A Clinical-Pathologic Study , 1990, Journal of Cognitive Neuroscience.

[155]  Daniel L. Schacter,et al.  Constructive memory: The ghosts of past and future , 2007, Nature.

[156]  H. Eichenbaum.  Time cells in the hippocampus: a new dimension for mapping memories , 2014, Nature Reviews Neuroscience.

[157]  L. Squire,et al.  Episodic memory, semantic memory, and amnesia , 1998, Hippocampus.

[158]  Morris Moscovitch,et al.  Annals of the New York Academy of Sciences Case Studies Continue to Illuminate the Cognitive Neuroscience of Memory , 2022 .

[159]  Neal J. Cohen,et al.  Processing and short-term retention of relational information in amnesia , 2004, Neuropsychologia.

[160]  M. K. Jones,et al.  Imagery as a mnemonic aid after left temporal lobectomy: contrast between material-specific and generalized memory disorders. , 1974, Neuropsychologia.

[161]  Eleanor A. Maguire,et al.  Patient HC with developmental amnesia can construct future scenarios , 2011, Neuropsychologia.

[162]  D. Hassabis,et al.  Scene Construction in Amnesia: An fMRI Study , 2012, The Journal of Neuroscience.

[163]  L. Squire.  Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. , 1992, Psychological review.

[164]  Ramona O. Hopkins,et al.  Comparison of explicit and incidental learning strategies in memory-impaired patients , 2013, Proceedings of the National Academy of Sciences.

[165]  Kristin N. Mauldin,et al.  Role of the hippocampus in remembering the past and imagining the future , 2010, Proceedings of the National Academy of Sciences.

[166]  Andrew P. Yonelinas,et al.  Detecting Changes in Scenes: The Hippocampus Is Critical for Strength-Based Perception , 2013, Neuron.

[167]  C. Ferguson,et al.  A Vast Graveyard of Undead Theories , 2012, Perspectives on psychological science : a journal of the Association for Psychological Science.

[168]  D. Murman,et al.  An autopsy case of limbic encephalitis with voltage‐gated potassium channel antibodies , 2007, European journal of neurology.

[169]  Sarah Brown-Schmidt,et al.  How Do I Remember That I Know You Know That I Know? , 2011, Psychological science.

[170]  Morris Moscovitch,et al.  Remote spatial memory in an amnesic person with extensive bilateral hippocampal lesions , 2000, Nature Neuroscience.

[171]  H. Intraub,et al.  Wide-angle memories of close-up scenes. , 1989, Journal of experimental psychology. Learning, memory, and cognition.

[172]  D. Hassabis,et al.  Deconstructing episodic memory with construction , 2007, Trends in Cognitive Sciences.

[173]  Russell A. Epstein,et al.  Perceptual deficits in amnesia: challenging the medial temporal lobe ‘mnemonic’ view , 2005, Neuropsychologia.

[174]  R. Adolphs,et al.  Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans , 1995, Science.

[175]  N. Cohen,et al.  Amnesia is a Deficit in Relational Memory , 2000, Psychological science.

[176]  L. Squire,et al.  Memory, Visual Discrimination Performance, and the Human Hippocampus , 2011, The Journal of Neuroscience.

[177]  D Tsivilis,et al.  Associative recognition in a patient with selective hippocampal lesions and relatively normal item recognition , 2004, Hippocampus.

[178]  Ramona O Hopkins,et al.  Successful Recollection of Remote Autobiographical Memories by Amnesic Patients with Medial Temporal Lobe Lesions , 2003, Neuron.

[179]  G. Winocur,et al.  Amnesia as an impairment of detail generation and binding: Evidence from personal, fictional, and semantic narratives in K.C. , 2009, Neuropsychologia.

[180]  D J Brooks,et al.  Temporally‐specific retrograde amnesia in two cases of discrete bilateral hippocampal pathology , 1999, Hippocampus.

[181]  Andy C. H. Lee,et al.  The hippocampus and visual perception , 2012, Front. Hum. Neurosci..

[182]  Morris Moscovitch,et al.  Rapid neocortical acquisition of long-term arbitrary associations independent of the hippocampus , 2011, Proceedings of the National Academy of Sciences.

[183]  S. Sala,et al.  Predicting the future , 2011, Cortex.

[184]  K. S. Graham,et al.  Extrastriate cortex and medial temporal lobe regions respond differentially to visual feature overlap within preferred stimulus category , 2012, Neuropsychologia.

[185]  R. N. Spreng,et al.  The Future of Memory: Remembering, Imagining, and the Brain , 2012, Neuron.

[186]  David E. Warren,et al.  Long-Term Neuropsychological, Neuroanatomical, and Life Outcome in Hippocampal Amnesia , 2012, The Clinical neuropsychologist.

[187]  N. Burgess,et al.  The hippocampus is required for short‐term topographical memory in humans , 2007, Hippocampus.

[188]  J. O'Keefe,et al.  The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. , 1971, Brain research.

[189]  Brenda Milner,et al.  Visually-guided maze learning in man: effects of bilateral hippocampal, bilateral frontal, and unilateral cerebral lesions , 1965 .

[190]  M. Mishkin,et al.  Developmental amnesia associated with early hypoxic-ischaemic injury. , 2000, Brain : a journal of neurology.

[191]  Alana T. Wong,et al.  Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration , 2007, Neuropsychologia.

[192]  Mark D'Esposito,et al.  Focal Brain Lesions to Critical Locations Cause Widespread Disruption of the Modular Organization of the Brain , 2012, Journal of Cognitive Neuroscience.

[193]  Arne D. Ekstrom,et al.  Cellular networks underlying human spatial navigation , 2003, Nature.

[194]  J. Aggleton,et al.  Hippocampal lesions halve immediate–early gene protein counts in retrosplenial cortex: distal dysfunctions in a spatial memory system , 2007, The European journal of neuroscience.

[195]  David E Warren,et al.  Not so fast: Hippocampal amnesia slows word learning despite successful fast mapping , 2014, Hippocampus.

[196]  P. Goldman-Rakic,et al.  Preface: Cerebral Cortex Has Come of Age , 1991 .

[197]  D. Tranel,et al.  Hippocampal damage abolishes the cortisol response to psychosocial stress in humans , 2009, Hormones and Behavior.

[198]  H. Eichenbaum.  Hippocampus Cognitive Processes and Neural Representations that Underlie Declarative Memory , 2004, Neuron.

[199]  M. Mishkin,et al.  Differential effects of early hippocampal pathology on episodic and semantic memory. , 1997, Science.

[200]  L. Squire,et al.  When recognition memory is independent of hippocampal function , 2014, Proceedings of the National Academy of Sciences.

[201]  N. Cohen,et al.  Empathy in Hippocampal Amnesia , 2013, Front. Psychol..

[202]  E. Maguire,et al.  The effect of hippocampal damage in children on recalling the past and imagining new experiences , 2011, Neuropsychologia.

[203]  Karl J. Friston,et al.  Degeneracy and cognitive anatomy , 2002, Trends in Cognitive Sciences.

[204]  J. Gray.  The neuropsychology of anxiety. , 1985, Issues in mental health nursing.

[205]  H. J. Spiers,et al.  The neuroscience of remote spatial memory: A tale of two cities , 2007, Neuroscience.

[206]  Indre V. Viskontas,et al.  Remote Episodic Memory Deficits in Patients with Unilateral Temporal Lobe Epilepsy and Excisions , 2000, The Journal of Neuroscience.

[207]  D. Hassabis,et al.  Using Imagination to Understand the Neural Basis of Episodic Memory , 2007, The Journal of Neuroscience.

[208]  Sylvain Gagnon,et al.  Involvement of the hippocampus in implicit learning of supra-span sequences: The case of sj , 2004, Cognitive neuropsychology.

[209]  M. Gluck,et al.  Probabilistic classification learning in amnesia. , 1994, Learning & memory.

[210]  E. Maguire,et al.  Navigation around London by a taxi driver with bilateral hippocampal lesions. , 2006, Brain : a journal of neurology.

[211]  D. J. Felleman,et al.  Distributed hierarchical processing in the primate cerebral cortex. , 1991, Cerebral cortex.

[212]  E. Tulving.  [Episodic memory: from mind to brain]. , 2004, Revue neurologique.

[213]  Larry R Squire,et al.  Quantifying medial temporal lobe damage in memory‐impaired patients † , 2005, Hippocampus.

[214]  T. Teyler,et al.  The role of hippocampus in memory: A hypothesis , 1985, Neuroscience & Biobehavioral Reviews.